The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

K Silventoinen; A Jelenkovic; Y Yokoyama; R Sund; M Sugawara; M Tanaka; S Matsumoto; L H Bogl; D L Freitas; J A Maia; J V B Hjelmborg; S Aaltonen; M Piirtola; A Latvala; L Calais-Ferreira; V C Oliveira; P H Ferreira; F Ji; F Ning; Z Pang; J R Ordoñana; J F Sánchez-Romera; L Colodro-Conde; S A Burt; K L Klump; N G Martin; S E Medland; G W Montgomery; C Kandler; T A McAdams; T C Eley; A M Gregory; K J Saudino; L Dubois; M Boivin; M Brendgen; G Dionne; F Vitaro; A D Tarnoki; D L Tarnoki; C M A Haworth; R Plomin; S Y Öncel; F Aliev; E Medda; L Nisticò; V Toccaceli; J M Craig; R Saffery; S H Siribaddana; M Hotopf; A Sumathipala; F Rijsdijk; H-U Jeong; T Spector; M Mangino; G Lachance; M Gatz; D A Butler; W Gao; C Yu; L Li; G Bayasgalan; D Narandalai; K P Harden; E M Tucker-Drob; K Christensen; A Skytthe; K O Kyvik; C A Derom; R F Vlietinck; R J F Loos; W Cozen; A E Hwang; T M Mack; M He; X Ding; J L Silberg; H H Maes; T L Cutler; J L Hopper; P K E Magnusson; N L Pedersen; A K Dahl Aslan; L A Baker; C Tuvblad; M Bjerregaard-Andersen; H Beck-Nielsen; M Sodemann; V Ullemar; C Almqvist; Q Tan; D Zhang; G E Swan; R Krasnow; K L Jang; A Knafo-Noam; D Mankuta; L Abramson; P Lichtenstein; R F Krueger; M McGue; S Pahlen; P Tynelius; F Rasmussen; G E Duncan; D Buchwald; R P Corley; B M Huibregtse; T L Nelson; K E Whitfield; C E Franz; W S Kremen; M J Lyons; S Ooki; I Brandt; T S Nilsen; J R Harris; J Sung; H A Park; J Lee; S J Lee; Gonneke Willemsen; Meike Bartels; C.E.M. van Beijsterveldt; C H Llewellyn; A Fisher; E Rebato; A Busjahn; R Tomizawa; F Inui; M Watanabe; C Honda; N Sakai; Y-M Hur; T I A Sørensen; D.I. Boomsma; J Kaprio

doi:10.1017/thg.2019.35

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

K Silventoinen, A Jelenkovic, Y Yokoyama, R Sund, M Sugawara, M Tanaka, S Matsumoto, L H Bogl, D L Freitas, J A Maia, J V B Hjelmborg, S Aaltonen, M Piirtola, A Latvala, L Calais-Ferreira, V C Oliveira, P H Ferreira, F Ji, F Ning, Z PangJ R Ordoñana, J F Sánchez-Romera, L Colodro-Conde, S A Burt, K L Klump, N G Martin, S E Medland, G W Montgomery, C Kandler, T A McAdams, T C Eley, A M Gregory, K J Saudino, L Dubois, M Boivin, M Brendgen, G Dionne, F Vitaro, A D Tarnoki, D L Tarnoki, C M A Haworth, R Plomin, S Y Öncel, F Aliev, E Medda, L Nisticò, V Toccaceli, J M Craig, R Saffery, S H Siribaddana, M Hotopf, A Sumathipala, F Rijsdijk, H-U Jeong, T Spector, M Mangino, G Lachance, M Gatz, D A Butler, W Gao, C Yu, L Li, G Bayasgalan, D Narandalai, K P Harden, E M Tucker-Drob, K Christensen, A Skytthe, K O Kyvik, C A Derom, R F Vlietinck, R J F Loos, W Cozen, A E Hwang, T M Mack, M He, X Ding, J L Silberg, H H Maes, T L Cutler, J L Hopper, P K E Magnusson, N L Pedersen, A K Dahl Aslan, L A Baker, C Tuvblad, M Bjerregaard-Andersen, H Beck-Nielsen, M Sodemann, V Ullemar, C Almqvist, Q Tan, D Zhang, G E Swan, R Krasnow, K L Jang, A Knafo-Noam, D Mankuta, L Abramson, P Lichtenstein, R F Krueger, M McGue, S Pahlen, P Tynelius, F Rasmussen, G E Duncan, D Buchwald, R P Corley, B M Huibregtse, T L Nelson, K E Whitfield, C E Franz, W S Kremen, M J Lyons, S Ooki, I Brandt, T S Nilsen, J R Harris, J Sung, H A Park, J Lee, S J Lee, Gonneke Willemsen, Meike Bartels, C.E.M. van Beijsterveldt, C H Llewellyn, A Fisher, E Rebato, A Busjahn, R Tomizawa, F Inui, M Watanabe, C Honda, N Sakai, Y-M Hur, T I A Sørensen, D.I. Boomsma, J Kaprio

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Abstract

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

Original language	English
Pages (from-to)	800-808
Number of pages	9
Journal	Twin research and human genetics : the official journal of the International Society for Twin Studies
Volume	22
Issue number	6
Early online date	31 Jul 2019
DOIs	https://doi.org/10.1017/thg.2019.35
Publication status	Published - Dec 2019

Bibliographical note

Special Issue 6: Twin family registries worldwide : An important resource for scientific research

Funding

This study was conducted within the CODATwins project (Academy of Finland #266592). K Silventoinen is supported by Osaka University’s International Joint Research Promotion Program. This research was facilitated through access to Twins Research Australia, a national resource supported by a Centre of Research Excellence Grant (ID: 1079102), from the National Health and Medical Research Council. The Boston University Twin Project is funded by grants (#R01 HD068435 #R01 MH062375) from the National Institutes of Health to K. Saudino. Paulo Ferreira is funded by a National Medical Research Council Research Fellowship. California Twin Program was supported by The California Tobacco-Related Disease Research Program (7RT-0134H, 8RT-0107H, 6RT-0354H) and the National Institutes of Health (1R01ESO15150-01). The Carolina African American Twin Study of Aging (CAATSA) was funded by a grant from the National Institute on Aging (grant 1RO1-AG13662-01A2) to K. E. Whitfield. The CATSS-Study is supported by the Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social And Medical Sciences (SIMSAM) framework grant no 340-2013-5867, grants provided by the Stockholm County Council (ALF-projects), the Swedish Heart-Lung Foundation and the Swedish Asthma and Allergy Association’s Research Foundation. Chinese National Twin Registry is funded by Special Fund for Health Scientific Research in the Public Welfare (Project No: 201502006), China. Colorado Twin Registry is funded by NIDA-funded center grant DA011015, & Longitudinal Twin Study HD10333; Author Huibregtse is supported by 5T32DA017637 and 5T32AG052371. Danish Twin Registry is supported by the National Program for Research Infrastructure 2007 from the Danish Agency for Science, Technology and Innovation, The Research Council for Health and Disease, the Velux Foundation and the US National Institute of Health (P01 AG08761). Since its origin, the East Flanders Prospective Survey has been partly supported by grants from the Fund of Scientific Research, Flanders and Twins, a nonprofit Association for Scientific Research in Multiple Births (Belgium). Data collection and analyses in Finnish twin cohorts have been supported by ENGAGE — European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007, grant agreement number 201413, National Institute of Alcohol Abuse and Alcoholism (grants AA-12502, AA-00145 and AA-09203 to R J Rose, the Academy of Finland Center of Excellence in Complex Disease Genetics (grant numbers: 213506, 129680), and the Academy of Finland (grants 100499, 205585, 118555, 141054, 265240, 263278 and 264146 to J Kaprio). Gemini was supported by a grant from Cancer Research UK (C1418/A7974). Waves 1–3 of Genesis 12–19 were funded by the W T Grant Foundation, the University of London Central Research fund and a Medical Research Council Training Fellowship (G81/343) and Career Development Award (G120/635) to Thalia C. Eley. Wave 4 was supported by grants from the Economic and Social Research Council (RES-000-22-2206) and the Institute of Social Psychiatry (06/07–11) to Alice M. Gregory, who was also supported at that time by a Leverhulme Research Fellowship (RF/2/RFG/2008/0145). Wave 5 was supported by funding to Alice M. Gregory from Goldsmiths, University of London. T. C. Eley is partly funded by a program grant from the UK Medical Research Council (MR/M021475/1). This study presents independent research [partly] funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. The Minnesota Twin Registry (MTR) acknowledges support from NIH grant R01AG053217. Guangzhou Twin Eye Study is supported by National Natural Science Foundation of China (grant #81125007). Anthropometric measurements of the Hungarian twins were supported by Medexpert Ltd., Budapest, Hungary. Korean Twin-Family Register was supported by the Global Research Network Program of the National Research Foundation (NRF 2011-220-E00006). Longitudinal Israeli Study of Twins was funded by the Starting Grant no. 240994 from the European Research Council (ERC) to Ariel Knafo. The Michigan State University Twin Registry has been supported by Michigan State University, as well as grants R01-MH081813, R01-MH0820-54, R01-MH092377-02, R21-MH070542-01, R03-MH63851-01 and 1R01-MH118848-01 from the National Institute of Mental Health (NIMH), R01-HD066040 from the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) and 11-SPG-2518 from the MSU Foundation. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the NIMH, the NICHD or the National Institutes of Health. The Murcia Twin Registry is supported by Fundación Séneca, Regional Agency for Science and Technology, Murcia, Spain (08633/PHCS/08, 15302/PHCS/10 & 19479/PI/14) and Ministry of Science and Innovation, Spain (PSI2009-11560 & PSI2014-56680-R). The NAS–NRC Twin Registry acknowledges financial support from the National Institutes of Health grant number R21 AG039572. Netherlands Twin Register acknowledges the Netherlands Organization for Scientific Research (NWO) and MagW/ZonMW grants 904-61-090, 985-10-002, 912-10-020, 904-61-193,480-04-004, 463-06-001, 451-04-034, 400-05-717, Addiction-31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192; VU University’s Institute for Health and Care Research (EMGO+); the European Research Council (ERC-230374), the Avera Institute, Sioux Falls, South Dakota (USA). Osaka University Aged Twin Registry is supported by grants from JSPS KAKENHI JP (23593419, 24792601, 26671010, 24590695, 26293128, 16K15385, 16K15978, 16K15989, 16H03261). PETS was supported by grants from the Australian National Health and Medical Research Council (grant numbers 437015 and 607358 to JC, and RS), the Bonnie Babes Foundation (grant number BBF20704 to JMC), the Financial Markets Foundation for Children (grant no. 032-2007 to JMC), and by the Victorian Government’s Operational Infrastructure Support Program. Madeira data comes from the following project: Genetic and environmental influences on physical activity, fitness and health: the Madeira family study Project reference: POCI/DES/56834/2004 Founded by the Portuguese agency for research (The Foundation for Science and Technology [FCT]). TwinsUK receives funding from the Wellcome Trust, Medical Research Council and European Union. TwinsUK and M. Mangino are supported by the National Institute for Health Research (NIHR)-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. The Quebec Newborn Twin Study acknowledges financial support from the Fonds Québécois de la Recherche sur la Société et la Culture, the Fonds de la Recherche en Santé du Québec, the Social Science and Humanities Research Council of Canada, the National Health Research Development Program, the Canadian Institutes for Health Research, Sainte-Justine Hospital’s Research Center, and the Canada Research Chair Program (Michel Boivin). South Korea Twin Registry is supported by National Research Foundation of Korea (NRF-371-2011-1 B00047). We acknowledge The Swedish Twin Registry for access to data. The Swedish Twin Registry is managed by Karolinska Institutet and receives funding through the Swedish Research Council under the grant no. 2017-00641. The Twins Early Development Study (TEDS) is supported by a program grant (G0901245) from the UK Medical Research Council and the work on obesity in TEDS is supported in part by a grant from the UK Biotechnology and Biological Sciences Research Council (31/D19086). Currently TEDS is supported by MRC grant ‘MR/M021475/1’. The Texas Twin Project is currently funded by grant R01HD083613 from the National Institutes of Health. S. Y. Öncel and F. Aliev are supported by Kırıkkale University Research Grant: KKU, 2009/43 and TUBITAK grant 114C117. The University of Southern California Twin Study is funded by a grant from the National Institute of Mental Health (R01 MH58354). Washington State Twin Registry (formerly the University of Washington Twin Registry) was supported in part by grant NIH RC2 HL103416 (D. Buchwald, PI). Vietnam Era Twin Study of Aging was supported by National Institute of Health grants NIA R01 AG018384, R01 AG018386, R01 AG022381 and R01 AG022982, and, in part, with resources of the VA San Diego Center of Excellence for Stress and Mental Health. The Cooperative Studies Program of the Office of Research & Development of the United States Department of Veterans Affairs has provided financial support for the development and maintenance of the Vietnam Era Twin (VET) Registry. The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the NIA/NIH, or the VA. The West Japan Twins and Higher Order Multiple Births Registry was supported by Grant-in-Aid for Scientific Research (B) (grant number 15H05105) from the Japan Society for the Promotion of Science.

Funders	Funder number
United States Department of Veterans Affairs	15H05105
Office of Research and Development
Research Council for Health and Disease
National Institute for Health Research
Fund of Scientific Research, Flanders and Twins
FundaciÃ³n SÃ©neca
Fonds de Recherche du QuÃ©bec - SantÃ©
Stockholms LÃ¤ns Landsting
Tobacco-Related Disease Research Program	6RT-0354H, 8RT-0107H, 1R01ESO15150-01
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Social Sciences and Humanities Research Council of Canada
Academy of Finland	264146, 141054, 205585, 263278, 118555, 265240, 100499
Economic and Social Research Council	RES-000-22-2206
National Research Foundation	240994, 2011-220-E00006
US National Institute of Health	P01 AG08761
Financial Markets Foundation for Children	032-2007
National Medical Research Council
Kingâs College London
SIMSAM	340-2013-5867
HjÃ¤rt-Lungfonden
Biotechnology and Biological Sciences Research Council	31/D19086
Cancer Research UK	C1418/A7974
VetenskapsrÃ¥det
Netherlands Organization for Scientific Research
W T Grant Foundation
Swedish Initiative for Research on Microdata in the Social And Medical Sciences
Academy of Finland Center of Excellence in Complex Disease Genetics	213506, 129680
Eunice Kennedy Shriver National Institute of Child Health and Human Development	11-SPG-2518
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	463-06-001, 904-61-090, 904-61-193,480-04-004, 400-05-717, 451-04-034, 985-10-002, 56-464-14192, 912-10-020
Mauritius Research Council	R01HD083613
Swedish Asthma and Allergy Association’s Research Foundation
State Government of Victoria
Special Fund for Forest Scientific Research in the Public Welfare	201502006
Velux Stiftung
National Institutes of Health
European Commission
National Institutes of Health	R01AG053217
National Institute of Health
TUBITAK	R01 MH58354, 114C117, RC2 HL103416
Ministry of Science and Innovation, Spain	PSI2009-11560, R21 AG039572, PSI2014-56680-R
Institute of Social Psychiatry	06/07–11
National Natural Science Foundation of China	81125007
National Institute on Aging	1RO1-AG13662-01A2
Wellcome Trust
University of London
National Institute of Mental Health	R01-HD066040
Regional Agency for Science and Technology, Murcia, Spain	08633/PHCS/08, 15302/PHCS/10, 19479/PI/14
Canadian Institutes of Health Research
National Health and Medical Research Council	01 HD068435 #R01 MH062375
Leverhulme Trust	RF/2/RFG/2008/0145
Australian National Health and Medical Research Council	437015, 607358
Japan Society for the Promotion of Science
National Institute on Aging	R01 AG022381, R01 AG018384, R01 AG022982, R01 AG018386
Medexpert Ltd.
Michigan State University	R01-MH0820-54, R21-MH070542-01, R01-MH092377-02, R01-MH081813, 1R01-MH118848-01, R03-MH63851-01
Fonds QuÃ©bÃ©cois de la Recherche sur la Nature et les Technologies
Danish Agency for Science and Higher Education
Khon Kaen University	2009/43
National Health Research Development Program
Japan Society for the Promotion of Science	24590695, 16K15989, 16K15978, 16H03261, 16K15385, 26293128, 23593419, 26671010, 24792601
South London and Maudsley NHS Foundation Trust
Medical Research Council	G120/635, G81/343
Bonnie Babes Foundation	BBF20704
VU University’s Institute for Health and Care Research	ERC-230374
Karolinska Institutet	2017-00641, G0901245
Association for Scientific Research in Multiple Births
MSU Foundation
Osaka University	1079102
Avera Institute
Sainte-Justine Hospital’s Research Center
FP7-HEALTH-F4-2007	201413
European Research Council
National Institute for Health Research
National Institute of Mental Health
National Institute on Alcohol Abuse and Alcoholism	AA-00145, AA-09203, AA-12502
Kırıkkale University
Canada Research Chair
National Research Foundation of Korea	NRF-371-2011-1 B00047
UK Medical Research Council	MR/M021475/1
NIDA-funded	5T32DA017637, 5T32AG052371, DA011015, HD10333

Keywords

BMI
Twins
birth size
education
height
heritability
international comparisons

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/thg.2019.35

codatwins_project_the_current_status_and_recent_findings_of_collaborative_project_of_development_of_anthropometrical_measures_in_twinsFinal published version, 261 KBLicence: Article 25fa Dutch Copyright Act

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Cite this

Silventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., Matsumoto, S., Bogl, L. H., Freitas, D. L., Maia, J. A., Hjelmborg, J. V. B., Aaltonen, S., Piirtola, M., Latvala, A., Calais-Ferreira, L., Oliveira, V. C., Ferreira, P. H., Ji, F., Ning, F., ... Kaprio, J. (2019). The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. Twin research and human genetics : the official journal of the International Society for Twin Studies, 22(6), 800-808. https://doi.org/10.1017/thg.2019.35

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title = "The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins",

abstract = "The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.",

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author = "K Silventoinen and A Jelenkovic and Y Yokoyama and R Sund and M Sugawara and M Tanaka and S Matsumoto and Bogl, {L H} and Freitas, {D L} and Maia, {J A} and Hjelmborg, {J V B} and S Aaltonen and M Piirtola and A Latvala and L Calais-Ferreira and Oliveira, {V C} and Ferreira, {P H} and F Ji and F Ning and Z Pang and Ordo{\~n}ana, {J R} and S{\'a}nchez-Romera, {J F} and L Colodro-Conde and Burt, {S A} and Klump, {K L} and Martin, {N G} and Medland, {S E} and Montgomery, {G W} and C Kandler and McAdams, {T A} and Eley, {T C} and Gregory, {A M} and Saudino, {K J} and L Dubois and M Boivin and M Brendgen and G Dionne and F Vitaro and Tarnoki, {A D} and Tarnoki, {D L} and Haworth, {C M A} and R Plomin and {\"O}ncel, {S Y} and F Aliev and E Medda and L Nistic{\`o} and V Toccaceli and Craig, {J M} and R Saffery and Siribaddana, {S H} and M Hotopf and A Sumathipala and F Rijsdijk and H-U Jeong and T Spector and M Mangino and G Lachance and M Gatz and Butler, {D A} and W Gao and C Yu and L Li and G Bayasgalan and D Narandalai and Harden, {K P} and Tucker-Drob, {E M} and K Christensen and A Skytthe and Kyvik, {K O} and Derom, {C A} and Vlietinck, {R F} and Loos, {R J F} and W Cozen and Hwang, {A E} and Mack, {T M} and M He and X Ding and Silberg, {J L} and Maes, {H H} and Cutler, {T L} and Hopper, {J L} and Magnusson, {P K E} and Pedersen, {N L} and {Dahl Aslan}, {A K} and Baker, {L A} and C Tuvblad and M Bjerregaard-Andersen and H Beck-Nielsen and M Sodemann and V Ullemar and C Almqvist and Q Tan and D Zhang and Swan, {G E} and R Krasnow and Jang, {K L} and A Knafo-Noam and D Mankuta and L Abramson and P Lichtenstein and Krueger, {R F} and M McGue and S Pahlen and P Tynelius and F Rasmussen and Duncan, {G E} and D Buchwald and Corley, {R P} and Huibregtse, {B M} and Nelson, {T L} and Whitfield, {K E} and Franz, {C E} and Kremen, {W S} and Lyons, {M J} and S Ooki and I Brandt and Nilsen, {T S} and Harris, {J R} and J Sung and Park, {H A} and J Lee and Lee, {S J} and Gonneke Willemsen and Meike Bartels and {van Beijsterveldt}, C.E.M. and Llewellyn, {C H} and A Fisher and E Rebato and A Busjahn and R Tomizawa and F Inui and M Watanabe and C Honda and N Sakai and Y-M Hur and S{\o}rensen, {T I A} and D.I. Boomsma and J Kaprio",

note = "Special Issue 6: Twin family registries worldwide : An important resource for scientific research",

year = "2019",

month = dec,

doi = "10.1017/thg.2019.35",

language = "English",

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pages = "800--808",

journal = "Twin research and human genetics : the official journal of the International Society for Twin Studies",

issn = "1832-4274",

publisher = "Australian Academic Press",

number = "6",

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Silventoinen, K, Jelenkovic, A, Yokoyama, Y, Sund, R, Sugawara, M, Tanaka, M, Matsumoto, S, Bogl, LH, Freitas, DL, Maia, JA, Hjelmborg, JVB, Aaltonen, S, Piirtola, M, Latvala, A, Calais-Ferreira, L, Oliveira, VC, Ferreira, PH, Ji, F, Ning, F, Pang, Z, Ordoñana, JR, Sánchez-Romera, JF, Colodro-Conde, L, Burt, SA, Klump, KL, Martin, NG, Medland, SE, Montgomery, GW, Kandler, C, McAdams, TA, Eley, TC, Gregory, AM, Saudino, KJ, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Tarnoki, AD, Tarnoki, DL, Haworth, CMA, Plomin, R, Öncel, SY, Aliev, F, Medda, E, Nisticò, L, Toccaceli, V, Craig, JM, Saffery, R, Siribaddana, SH, Hotopf, M, Sumathipala, A, Rijsdijk, F, Jeong, H-U, Spector, T, Mangino, M, Lachance, G, Gatz, M, Butler, DA, Gao, W, Yu, C, Li, L, Bayasgalan, G, Narandalai, D, Harden, KP, Tucker-Drob, EM, Christensen, K, Skytthe, A, Kyvik, KO, Derom, CA, Vlietinck, RF, Loos, RJF, Cozen, W, Hwang, AE, Mack, TM, He, M, Ding, X, Silberg, JL, Maes, HH, Cutler, TL, Hopper, JL, Magnusson, PKE, Pedersen, NL, Dahl Aslan, AK, Baker, LA, Tuvblad, C, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Ullemar, V, Almqvist, C, Tan, Q, Zhang, D, Swan, GE, Krasnow, R, Jang, KL, Knafo-Noam, A, Mankuta, D, Abramson, L, Lichtenstein, P, Krueger, RF, McGue, M, Pahlen, S, Tynelius, P, Rasmussen, F, Duncan, GE, Buchwald, D, Corley, RP, Huibregtse, BM, Nelson, TL, Whitfield, KE, Franz, CE, Kremen, WS, Lyons, MJ, Ooki, S, Brandt, I, Nilsen, TS, Harris, JR, Sung, J, Park, HA, Lee, J, Lee, SJ, Willemsen, G , Bartels, M, van Beijsterveldt, CEM, Llewellyn, CH, Fisher, A, Rebato, E, Busjahn, A, Tomizawa, R, Inui, F, Watanabe, M, Honda, C, Sakai, N, Hur, Y-M, Sørensen, TIA, Boomsma, DI & Kaprio, J 2019, 'The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins', Twin research and human genetics : the official journal of the International Society for Twin Studies, vol. 22, no. 6, pp. 800-808. https://doi.org/10.1017/thg.2019.35

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. / Silventoinen, K; Jelenkovic, A; Yokoyama, Y et al.
In: Twin research and human genetics : the official journal of the International Society for Twin Studies, Vol. 22, No. 6, 12.2019, p. 800-808.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - The CODATwins Project

T2 - The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

AU - Silventoinen, K

AU - Jelenkovic, A

AU - Yokoyama, Y

AU - Sund, R

AU - Sugawara, M

AU - Tanaka, M

AU - Matsumoto, S

AU - Bogl, L H

AU - Freitas, D L

AU - Maia, J A

AU - Hjelmborg, J V B

AU - Aaltonen, S

AU - Piirtola, M

AU - Latvala, A

AU - Calais-Ferreira, L

AU - Oliveira, V C

AU - Ferreira, P H

AU - Ji, F

AU - Ning, F

AU - Pang, Z

AU - Ordoñana, J R

AU - Sánchez-Romera, J F

AU - Colodro-Conde, L

AU - Burt, S A

AU - Klump, K L

AU - Martin, N G

AU - Medland, S E

AU - Montgomery, G W

AU - Kandler, C

AU - McAdams, T A

AU - Eley, T C

AU - Gregory, A M

AU - Saudino, K J

AU - Dubois, L

AU - Boivin, M

AU - Brendgen, M

AU - Dionne, G

AU - Vitaro, F

AU - Tarnoki, A D

AU - Tarnoki, D L

AU - Haworth, C M A

AU - Plomin, R

AU - Öncel, S Y

AU - Aliev, F

AU - Medda, E

AU - Nisticò, L

AU - Toccaceli, V

AU - Craig, J M

AU - Saffery, R

AU - Siribaddana, S H

AU - Hotopf, M

AU - Sumathipala, A

AU - Rijsdijk, F

AU - Jeong, H-U

AU - Spector, T

AU - Mangino, M

AU - Lachance, G

AU - Gatz, M

AU - Butler, D A

AU - Gao, W

AU - Yu, C

AU - Li, L

AU - Bayasgalan, G

AU - Narandalai, D

AU - Harden, K P

AU - Tucker-Drob, E M

AU - Christensen, K

AU - Skytthe, A

AU - Kyvik, K O

AU - Derom, C A

AU - Vlietinck, R F

AU - Loos, R J F

AU - Cozen, W

AU - Hwang, A E

AU - Mack, T M

AU - He, M

AU - Ding, X

AU - Silberg, J L

AU - Maes, H H

AU - Cutler, T L

AU - Hopper, J L

AU - Magnusson, P K E

AU - Pedersen, N L

AU - Dahl Aslan, A K

AU - Baker, L A

AU - Tuvblad, C

AU - Bjerregaard-Andersen, M

AU - Beck-Nielsen, H

AU - Sodemann, M

AU - Ullemar, V

AU - Almqvist, C

AU - Tan, Q

AU - Zhang, D

AU - Swan, G E

AU - Krasnow, R

AU - Jang, K L

AU - Knafo-Noam, A

AU - Mankuta, D

AU - Abramson, L

AU - Lichtenstein, P

AU - Krueger, R F

AU - McGue, M

AU - Pahlen, S

AU - Tynelius, P

AU - Rasmussen, F

AU - Duncan, G E

AU - Buchwald, D

AU - Corley, R P

AU - Huibregtse, B M

AU - Nelson, T L

AU - Whitfield, K E

AU - Franz, C E

AU - Kremen, W S

AU - Lyons, M J

AU - Ooki, S

AU - Brandt, I

AU - Nilsen, T S

AU - Harris, J R

AU - Sung, J

AU - Park, H A

AU - Lee, J

AU - Lee, S J

AU - Willemsen, Gonneke

AU - Bartels, Meike

AU - van Beijsterveldt, C.E.M.

AU - Llewellyn, C H

AU - Fisher, A

AU - Rebato, E

AU - Busjahn, A

AU - Tomizawa, R

AU - Inui, F

AU - Watanabe, M

AU - Honda, C

AU - Sakai, N

AU - Hur, Y-M

AU - Sørensen, T I A

AU - Boomsma, D.I.

AU - Kaprio, J

N1 - Special Issue 6: Twin family registries worldwide : An important resource for scientific research

PY - 2019/12

Y1 - 2019/12

N2 - The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

AB - The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.

KW - BMI

KW - Twins

KW - birth size

KW - education

KW - height

KW - heritability

KW - international comparisons

UR - http://www.scopus.com/inward/record.url?scp=85070056867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070056867&partnerID=8YFLogxK

U2 - 10.1017/thg.2019.35

DO - 10.1017/thg.2019.35

M3 - Article

C2 - 31364586

SN - 1832-4274

VL - 22

SP - 800

EP - 808

JO - Twin research and human genetics : the official journal of the International Society for Twin Studies

JF - Twin research and human genetics : the official journal of the International Society for Twin Studies

IS - 6

ER -

Silventoinen K, Jelenkovic A, Yokoyama Y, Sund R, Sugawara M, Tanaka M et al. The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins. Twin research and human genetics : the official journal of the International Society for Twin Studies. 2019 Dec;22(6):800-808. Epub 2019 Jul 31. doi: 10.1017/thg.2019.35

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

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UN SDGs

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