The conserved extension of the Hbp autotransporter signal peptide does not determine targeting pathway specificity.

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Autotransporters (ATs) of Gram-negative bacteria are often produced with an unusual signal peptide that carries a conserved N-terminal extension. Using combined in vitro and in vivo approaches we show that the extension of the AT hemoglobin protease (Hbp) does not affect targeting of Hbp via the SRP-pathway, suggesting that the extension is not involved in targeting pathway selection. © 2008 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)522-527
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume368
DOIs
Publication statusPublished - 2008

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Protein Sorting Signals
Hemoglobins
Peptide Hydrolases
Gram-Negative Bacteria
Bacteria
Type V Secretion Systems
In Vitro Techniques
DegP protease

Cite this

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title = "The conserved extension of the Hbp autotransporter signal peptide does not determine targeting pathway specificity.",
abstract = "Autotransporters (ATs) of Gram-negative bacteria are often produced with an unusual signal peptide that carries a conserved N-terminal extension. Using combined in vitro and in vivo approaches we show that the extension of the AT hemoglobin protease (Hbp) does not affect targeting of Hbp via the SRP-pathway, suggesting that the extension is not involved in targeting pathway selection. {\circledC} 2008 Elsevier Inc. All rights reserved.",
author = "W.S.P. Jong and S. Luirink",
year = "2008",
doi = "10.1016/j.bbrc.2008.01.122",
language = "English",
volume = "368",
pages = "522--527",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",

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T1 - The conserved extension of the Hbp autotransporter signal peptide does not determine targeting pathway specificity.

AU - Jong, W.S.P.

AU - Luirink, S.

PY - 2008

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N2 - Autotransporters (ATs) of Gram-negative bacteria are often produced with an unusual signal peptide that carries a conserved N-terminal extension. Using combined in vitro and in vivo approaches we show that the extension of the AT hemoglobin protease (Hbp) does not affect targeting of Hbp via the SRP-pathway, suggesting that the extension is not involved in targeting pathway selection. © 2008 Elsevier Inc. All rights reserved.

AB - Autotransporters (ATs) of Gram-negative bacteria are often produced with an unusual signal peptide that carries a conserved N-terminal extension. Using combined in vitro and in vivo approaches we show that the extension of the AT hemoglobin protease (Hbp) does not affect targeting of Hbp via the SRP-pathway, suggesting that the extension is not involved in targeting pathway selection. © 2008 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.bbrc.2008.01.122

DO - 10.1016/j.bbrc.2008.01.122

M3 - Article

VL - 368

SP - 522

EP - 527

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

ER -