The constitutive activity of the viral-encoded G protein-coupled receptor US28 supports a complex signalling network contributing to cancer development

Carole A. Daly, Martine J. Smit, Bianca Plouffe

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

US28 is a viral G protein-coupled receptor (GPCR) encoded by the human cytomegalovirus (HCMV). This receptor, expressed both during lytic replication and viral latency, is required for latency. US28 is binding to a wide variety of chemokines but also exhibits a particularly high constitutive activity robustly modulating a wide network of cellular pathways altering the host cell environment to benefit HCMV infection. Several studies suggest that US28-mediated signalling may contribute to cancer progression. In this review, we discuss the unique structural characteristics that US28 acquired through evolution that confer a robust constitutive activity to this viral receptor. We also describe the wide downstream signalling network activated by this constitutive activation of US28 and discuss how these signalling pathways may promote and support important cellular aspects of cancer.

Original languageEnglish
Pages (from-to)1493-1504
Number of pages12
JournalBiochemical Society transactions
Volume48
Issue number4
DOIs
Publication statusPublished - 28 Aug 2020

Keywords

  • cancer
  • chemokine receptor
  • constitutive activity
  • signalling network
  • US28
  • viral GCPR

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