The cost effectiveness of personalized dietary advice to increase protein intake in older adults with lower habitual protein intake: a randomized controlled trial

Ilse Reinders, Marjolein Visser, Satu K Jyväkorpi, Riikka T Niskanen, Judith E Bosmans, Ângela Jornada Ben, Ingeborg A Brouwer, Lothar D Kuijper, Margreet R Olthof, Kaisu H Pitkälä, Rachel Vijlbrief, Merja H Suominen, Hanneke A H Wijnhoven

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

PURPOSE: To examine the cost effectiveness of dietary advice to increase protein intake on 6-month change in physical functioning among older adults.

METHODS: In this multicenter randomized controlled trial, 276 community-dwelling older adults with a habitual protein intake < 1.0 g/kg adjusted body weight (aBW)/d were randomly assigned to either Intervention 1; advice to increase protein intake to ≥ 1.2 g/kg aBW/d (PROT, n = 96), Intervention 2; similar advice and in addition advice to consume protein (en)rich(ed) foods within half an hour after usual physical activity (PROT + TIMING, n = 89), or continue the habitual diet with no advice (CON, n = 91). Primary outcome was 6-month change in 400-m walk time. Secondary outcomes were 6-month change in physical performance, leg extension strength, grip strength, body composition, self-reported mobility limitations and quality of life. We evaluated cost effectiveness from a societal perspective.

RESULTS: Compared to CON, a positive effect on walk time was observed for PROT;  - 12.4 s (95%CI,  - 21.8 to  - 2.9), and for PROT + TIMING;  - 4.9 s (95%CI,  - 14.5 to 4.7). Leg extension strength significantly increased in PROT (+ 32.6 N (95%CI, 10.6-54.5)) and PROT + TIMING (+ 24.3 N (95%CI, 0.2-48.5)) compared to CON. No significant intervention effects were observed for the other secondary outcomes. From a societal perspective, PROT was cost effective compared to CON.

CONCLUSION: Dietary advice to increase protein intake to ≥ 1.2 g/kg aBW/d improved 400-m walk time and leg strength among older adults with a lower habitual protein intake. From a societal perspective, PROT was considered cost-effective compared to CON. These findings support the need for re-evaluating the protein RDA of 0.8 g/kg BW/d for older adults.

TRIAL REGISTRATION: The trial has been registered at ClinicalTrials.gov (NCT03712306). Date of registration: October 2018. Registry name: The (Cost) Effectiveness of Increasing Protein Intake on Physical Functioning in Older Adults. Trial Identifier: NCT03712306.

Original languageEnglish
JournalEuropean journal of nutrition
DOIs
Publication statusE-pub ahead of print - 5 Oct 2021

Bibliographical note

© 2021. The Author(s).

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