Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 385-405 |
| Number of pages | 21 |
| Journal | International Psychogeriatrics |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 |
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The course of neuropsychiatric symptoms in community-dwelling patients with dementia: a systematic review. / Borsje, P.; Wetzels, R.B.; Lucassen, P.L.; Pot, A.M.; Koopmans, R.T.
In: International Psychogeriatrics, Vol. 27, No. 3, 2015, p. 385-405.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - The course of neuropsychiatric symptoms in community-dwelling patients with dementia: a systematic review
AU - Borsje, P.
AU - Wetzels, R.B.
AU - Lucassen, P.L.
AU - Pot, A.M.
AU - Koopmans, R.T.
PY - 2015
Y1 - 2015
N2 - Background: Neuropsychiatric symptoms (NPS) often occur in patients with dementia. Understanding the course of NPS in dementia is important for healthcare professionals for psycho-educational purposes and adequate and timely interventions to prevent or diminish NPS as much as possible. Methods: We conducted a systematic literature search in several electronic databases. We combined search strings for the terms dementia, community-dwelling, cohort studies and NPS. Screening titles and abstracts, assessing the methodological quality and data-extraction were independently conducted by at least two authors. Results: This literature search revealed 6605 unique records of which 23 studies were included in data synthesis. In total 7184 patients participated in the included studies with a mean number of 312. Sixty percent of the participants were female and the mean age of all participants was 74.8 years. Follow-up varied between 1 and 6 years; in 17 studies loss to follow-up was less than 20% per year. NPS are highly prevalent, incident and persistent although frequency parameters vary considerably across studies. Delusions/delusional misidentification, wandering/agitation, aberrant motor behavior/motor hyperactivity and apathy are the most common NPS. For hallucinations, delusions/delusional misidentification, paranoia, aggression, wandering/agitation, aberrant motor behavior/motor hyperactivity, disinhibition, apathy, and sleep disturbance increasing trends in point prevalence rates have been found. Conclusions: NPS in community-dwelling patients are frequent and persistent. The increasing trends of several NPS in the course of dementia require a preventive approach of professional caretakers. For such an approach, a timely diagnosis and adequate professional support to prevent or diminish these problems is necessary.
AB - Background: Neuropsychiatric symptoms (NPS) often occur in patients with dementia. Understanding the course of NPS in dementia is important for healthcare professionals for psycho-educational purposes and adequate and timely interventions to prevent or diminish NPS as much as possible. Methods: We conducted a systematic literature search in several electronic databases. We combined search strings for the terms dementia, community-dwelling, cohort studies and NPS. Screening titles and abstracts, assessing the methodological quality and data-extraction were independently conducted by at least two authors. Results: This literature search revealed 6605 unique records of which 23 studies were included in data synthesis. In total 7184 patients participated in the included studies with a mean number of 312. Sixty percent of the participants were female and the mean age of all participants was 74.8 years. Follow-up varied between 1 and 6 years; in 17 studies loss to follow-up was less than 20% per year. NPS are highly prevalent, incident and persistent although frequency parameters vary considerably across studies. Delusions/delusional misidentification, wandering/agitation, aberrant motor behavior/motor hyperactivity and apathy are the most common NPS. For hallucinations, delusions/delusional misidentification, paranoia, aggression, wandering/agitation, aberrant motor behavior/motor hyperactivity, disinhibition, apathy, and sleep disturbance increasing trends in point prevalence rates have been found. Conclusions: NPS in community-dwelling patients are frequent and persistent. The increasing trends of several NPS in the course of dementia require a preventive approach of professional caretakers. For such an approach, a timely diagnosis and adequate professional support to prevent or diminish these problems is necessary.
U2 - 10.1017/S1041610214002282
DO - 10.1017/S1041610214002282
M3 - Article
VL - 27
SP - 385
EP - 405
JO - International Psychogeriatrics
JF - International Psychogeriatrics
SN - 1041-6102
IS - 3
ER -