The course of neuropsychiatric symptoms in community-dwelling patients with dementia: a systematic review

P. Borsje, R.B. Wetzels, P.L. Lucassen, A.M. Pot, R.T. Koopmans

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Neuropsychiatric symptoms (NPS) often occur in patients with dementia. Understanding the course of NPS in dementia is important for healthcare professionals for psycho-educational purposes and adequate and timely interventions to prevent or diminish NPS as much as possible. Methods: We conducted a systematic literature search in several electronic databases. We combined search strings for the terms dementia, community-dwelling, cohort studies and NPS. Screening titles and abstracts, assessing the methodological quality and data-extraction were independently conducted by at least two authors. Results: This literature search revealed 6605 unique records of which 23 studies were included in data synthesis. In total 7184 patients participated in the included studies with a mean number of 312. Sixty percent of the participants were female and the mean age of all participants was 74.8 years. Follow-up varied between 1 and 6 years; in 17 studies loss to follow-up was less than 20% per year. NPS are highly prevalent, incident and persistent although frequency parameters vary considerably across studies. Delusions/delusional misidentification, wandering/agitation, aberrant motor behavior/motor hyperactivity and apathy are the most common NPS. For hallucinations, delusions/delusional misidentification, paranoia, aggression, wandering/agitation, aberrant motor behavior/motor hyperactivity, disinhibition, apathy, and sleep disturbance increasing trends in point prevalence rates have been found. Conclusions: NPS in community-dwelling patients are frequent and persistent. The increasing trends of several NPS in the course of dementia require a preventive approach of professional caretakers. For such an approach, a timely diagnosis and adequate professional support to prevent or diminish these problems is necessary.
Original languageEnglish
Pages (from-to)385-405
Number of pages21
JournalInternational Psychogeriatrics
Volume27
Issue number3
DOIs
Publication statusPublished - 2015

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Independent Living
Dementia
Hyperkinesis
Apathy
Delusions
Paranoid Disorders
Hallucinations
Aggression
Sleep
Cohort Studies
Databases
Delivery of Health Care

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Borsje, P. ; Wetzels, R.B. ; Lucassen, P.L. ; Pot, A.M. ; Koopmans, R.T. / The course of neuropsychiatric symptoms in community-dwelling patients with dementia: a systematic review. In: International Psychogeriatrics. 2015 ; Vol. 27, No. 3. pp. 385-405.
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abstract = "Background: Neuropsychiatric symptoms (NPS) often occur in patients with dementia. Understanding the course of NPS in dementia is important for healthcare professionals for psycho-educational purposes and adequate and timely interventions to prevent or diminish NPS as much as possible. Methods: We conducted a systematic literature search in several electronic databases. We combined search strings for the terms dementia, community-dwelling, cohort studies and NPS. Screening titles and abstracts, assessing the methodological quality and data-extraction were independently conducted by at least two authors. Results: This literature search revealed 6605 unique records of which 23 studies were included in data synthesis. In total 7184 patients participated in the included studies with a mean number of 312. Sixty percent of the participants were female and the mean age of all participants was 74.8 years. Follow-up varied between 1 and 6 years; in 17 studies loss to follow-up was less than 20{\%} per year. NPS are highly prevalent, incident and persistent although frequency parameters vary considerably across studies. Delusions/delusional misidentification, wandering/agitation, aberrant motor behavior/motor hyperactivity and apathy are the most common NPS. For hallucinations, delusions/delusional misidentification, paranoia, aggression, wandering/agitation, aberrant motor behavior/motor hyperactivity, disinhibition, apathy, and sleep disturbance increasing trends in point prevalence rates have been found. Conclusions: NPS in community-dwelling patients are frequent and persistent. The increasing trends of several NPS in the course of dementia require a preventive approach of professional caretakers. For such an approach, a timely diagnosis and adequate professional support to prevent or diminish these problems is necessary.",
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The course of neuropsychiatric symptoms in community-dwelling patients with dementia: a systematic review. / Borsje, P.; Wetzels, R.B.; Lucassen, P.L.; Pot, A.M.; Koopmans, R.T.

In: International Psychogeriatrics, Vol. 27, No. 3, 2015, p. 385-405.

Research output: Contribution to JournalArticleAcademicpeer-review

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