Abstract
Post-mortem MRI provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy, and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes-Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank release includes twenty one distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen non-human primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The Digital Brain Bank is the culmination of our lab’s investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the Digital Brain Bank provides cross-scale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies.
| Original language | English |
|---|---|
| Article number | e73153 |
| Pages (from-to) | 1-35 |
| Number of pages | 35 |
| Journal | eLife |
| Volume | 11 |
| Early online date | 17 Mar 2022 |
| DOIs | |
| Publication status | Published - 26 Apr 2022 |
Bibliographical note
Funding Information:Human post-mortem brain datasets for the Digital Anatomist and Digital Pathologist used tissue provided by the Oxford Brain Bank, a research ethics committee (REC) approved, HTA regulated research tissue bank (REC reference 15/SC/0639). The Oxford Brain Bank is supported by the MRC, Brains for Dementia Research (BDR) (Alzheimer Society and Alzheimer Research UK), and the NIHR Oxford Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of
Funding Information:
The Digital Brain Bank is supported by the Wellcome Trust (202788/Z/16/Z) and Medical Research Council (MRC, MR/K02213X/1). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z).
Funding Information:
The Digital Brain Bank is supported by the Wellcome Trust (202788/Z/16/Z) and Medical Research Council (MRC, MR/K02213X/1). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z). KLM, BCT, AS and JM are supported by funding from the Wellcome Trust (202788/Z/16/Z), RBM is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/N019814/1) and the Netherlands Organization for Scientific Research NWO (452-13-015), SJ is supported by funding from the Wellcome Trust (221933/Z/20/Z, 215573/Z/19/Z) and the MRC (MR/L009013/1), TH and DM are supported by funding from the Wellcome Centre for Integrative Neuroimaging, OA is supported by funding from the Medical Research Council, Alzheimer?s UK and NIHR Oxford Biomedical Research Centre, MFB is supported by funding from the Alfred Benzon?s Foundation, KLB is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/N019814/1), SF and MPG are supported by funding from the MRC (MR/K02213X/1), MPvdH is supported by the Netherlands Organization for Scientific Research NWO (VIDI-452-16-015, ALW-179) and the European Research Council (ERC-COG 101001062) AFDH and IH are supported by funding from the Engineering and Physical Sciences Research Council (EPSRC, EP/L016052/1) and Medical Research Council (MRC, grant MR/L009013/1), AAK was funded by Cancer Research UK (grant C5255/A15935), PRM is supported by funding from the National Research Foundation of South Africa, RALM is supported by funding from the Medical Research Council (MR/K01014X/1) and the Wellcome Trust (202788/Z/16/Z), LR is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/M011224/1), JS is supported by funding from the IDEXLYON IMPULSION 2020 (IDEX/IMP/2020/14) and Labex CORTEX (ANR-11-LABX-0042) grant (Universit? de Lyon), CS is supported by funding from the NIHR Oxford Biomedical Research Centre (BRC), MRT is supported by funding from the Motor Neurone Disease Association, CW is supported by funding from the China Scholarship Council (CSC). Human post-mortem brain datasets for the Digital Anatomist and Digital Pathologist used tissue provided by the Oxford Brain Bank, a research ethics committee (REC) approved, HTA regulated research tissue bank (REC reference 15/SC/0639). The Oxford Brain Bank is supported by the MRC, Brains for Dementia Research (BDR) (Alzheimer Society and Alzheimer Research UK), and the NIHR Oxford Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Datasets for the Digital Brain Zoo used tissue provided by the Australian Museum, Copenhagen Zoo, Primate Brain Bank, Save the Tasmanian Devil, Smithsonian, University of Oxford, and Zoological Society of London.
Funding Information:
KLM, BCT, AS and JM are supported by funding from the Wellcome Trust (202788/Z/16/Z), RBM is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/N019814/1) and the Netherlands Organization for Scientific Research NWO (452-13-015), SJ is supported by funding from the Wellcome Trust (221933/Z/20/Z, 215573/Z/19/Z) and the MRC (MR/L009013/1), TH and DM are supported by funding from the Wellcome Centre for Integrative Neuroimaging, OA is supported by funding from the Medical ?esearch Council 唀 ?lzheimer 嬁? UK and NIH? Oxford Biomedical ?esearch C, eMnFtrBeis supported by funding from the ?lfred Benzon 嬁退 Foundat, iKoLnB is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/N019814/1), SF and MPG are supported by funding from the MRC (MR/K02213X/1), MPvdH is supported by the Netherlands Organization for Scientific Research NWO (VIDI-452-16-015, ALW-179) and the European Research Council (ERC-COG 101001062) AFDH and IH are supported by funding from the Engineering and Physical Sciences Research Council (EPSRC, EP/L016052/1) and Medical Research Council (MRC, grant MR/L009013/1), AAK was funded by Cancer Research UK (grant C5255/A15935), PRM is supported by funding from the National Research Foundation of South Africa, RALM is supported by funding from the Medical Research Council (MR/K01014X/1) and the Wellcome Trust (202788/Z/16/Z), LR is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/M011224/1), JS is supported by funding from the IDEXLYON IMPULSION 2020 (IDEX/IMP/2020/14) and Labex CORTEX (ANR-11-LABX-0042) grant (Université de Lyon), CS is supported by funding from the NIHR Oxford Biomedical Research Centre (BRC), MRT is supported by funding from the Motor Neurone Disease Association, CW is supported by funding from the China Scholarship Council (CSC).
Publisher Copyright:
© 2022, eLife Sciences Publications Ltd. All rights reserved.
Funding
Human post-mortem brain datasets for the Digital Anatomist and Digital Pathologist used tissue provided by the Oxford Brain Bank, a research ethics committee (REC) approved, HTA regulated research tissue bank (REC reference 15/SC/0639). The Oxford Brain Bank is supported by the MRC, Brains for Dementia Research (BDR) (Alzheimer Society and Alzheimer Research UK), and the NIHR Oxford Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of The Digital Brain Bank is supported by the Wellcome Trust (202788/Z/16/Z) and Medical Research Council (MRC, MR/K02213X/1). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z). The Digital Brain Bank is supported by the Wellcome Trust (202788/Z/16/Z) and Medical Research Council (MRC, MR/K02213X/1). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z). KLM, BCT, AS and JM are supported by funding from the Wellcome Trust (202788/Z/16/Z), RBM is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/N019814/1) and the Netherlands Organization for Scientific Research NWO (452-13-015), SJ is supported by funding from the Wellcome Trust (221933/Z/20/Z, 215573/Z/19/Z) and the MRC (MR/L009013/1), TH and DM are supported by funding from the Wellcome Centre for Integrative Neuroimaging, OA is supported by funding from the Medical Research Council, Alzheimer?s UK and NIHR Oxford Biomedical Research Centre, MFB is supported by funding from the Alfred Benzon?s Foundation, KLB is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/N019814/1), SF and MPG are supported by funding from the MRC (MR/K02213X/1), MPvdH is supported by the Netherlands Organization for Scientific Research NWO (VIDI-452-16-015, ALW-179) and the European Research Council (ERC-COG 101001062) AFDH and IH are supported by funding from the Engineering and Physical Sciences Research Council (EPSRC, EP/L016052/1) and Medical Research Council (MRC, grant MR/L009013/1), AAK was funded by Cancer Research UK (grant C5255/A15935), PRM is supported by funding from the National Research Foundation of South Africa, RALM is supported by funding from the Medical Research Council (MR/K01014X/1) and the Wellcome Trust (202788/Z/16/Z), LR is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/M011224/1), JS is supported by funding from the IDEXLYON IMPULSION 2020 (IDEX/IMP/2020/14) and Labex CORTEX (ANR-11-LABX-0042) grant (Universit? de Lyon), CS is supported by funding from the NIHR Oxford Biomedical Research Centre (BRC), MRT is supported by funding from the Motor Neurone Disease Association, CW is supported by funding from the China Scholarship Council (CSC). Human post-mortem brain datasets for the Digital Anatomist and Digital Pathologist used tissue provided by the Oxford Brain Bank, a research ethics committee (REC) approved, HTA regulated research tissue bank (REC reference 15/SC/0639). The Oxford Brain Bank is supported by the MRC, Brains for Dementia Research (BDR) (Alzheimer Society and Alzheimer Research UK), and the NIHR Oxford Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. Datasets for the Digital Brain Zoo used tissue provided by the Australian Museum, Copenhagen Zoo, Primate Brain Bank, Save the Tasmanian Devil, Smithsonian, University of Oxford, and Zoological Society of London. KLM, BCT, AS and JM are supported by funding from the Wellcome Trust (202788/Z/16/Z), RBM is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/N019814/1) and the Netherlands Organization for Scientific Research NWO (452-13-015), SJ is supported by funding from the Wellcome Trust (221933/Z/20/Z, 215573/Z/19/Z) and the MRC (MR/L009013/1), TH and DM are supported by funding from the Wellcome Centre for Integrative Neuroimaging, OA is supported by funding from the Medical ?esearch Council 唀 ?lzheimer 嬁? UK and NIH? Oxford Biomedical ?esearch C, eMnFtrBeis supported by funding from the ?lfred Benzon 嬁退 Foundat, iKoLnB is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/N019814/1), SF and MPG are supported by funding from the MRC (MR/K02213X/1), MPvdH is supported by the Netherlands Organization for Scientific Research NWO (VIDI-452-16-015, ALW-179) and the European Research Council (ERC-COG 101001062) AFDH and IH are supported by funding from the Engineering and Physical Sciences Research Council (EPSRC, EP/L016052/1) and Medical Research Council (MRC, grant MR/L009013/1), AAK was funded by Cancer Research UK (grant C5255/A15935), PRM is supported by funding from the National Research Foundation of South Africa, RALM is supported by funding from the Medical Research Council (MR/K01014X/1) and the Wellcome Trust (202788/Z/16/Z), LR is supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC) UK (BB/M011224/1), JS is supported by funding from the IDEXLYON IMPULSION 2020 (IDEX/IMP/2020/14) and Labex CORTEX (ANR-11-LABX-0042) grant (Université de Lyon), CS is supported by funding from the NIHR Oxford Biomedical Research Centre (BRC), MRT is supported by funding from the Motor Neurone Disease Association, CW is supported by funding from the China Scholarship Council (CSC).
| Funders | Funder number |
|---|---|
| Alzheimer’s Research UK | |
| Alzheimer's Society | |
| Save the Tasmanian Devil, Smithsonian, University of Oxford | |
| NIHR Oxford Biomedical Research Centre | |
| Zoological Society of London | |
| National Institute for Health Research | |
| Primate Brain Bank | |
| Motor Neurone Disease Association | |
| Oxford Brain Bank | |
| Université de Lyon | |
| China Scholarship Council | |
| Health Technology Assessment Programme | 15/SC/0639 |
| Engineering and Physical Sciences Research Council | EP/L016052/1 |
| Biotechnology and Biological Sciences Research Council | BB/N019814/1 |
| Wellcome Trust | 202788/Z/16/Z |
| Netherlands Organization for Scientific Research NWO | MR/L009013/1, 215573/Z/19/Z, 221933/Z/20/Z, 452-13-015 |
| National Institutes of Health | ALW-179, MR/K02213X/1, VIDI-452-16-015 |
| National Research Foundation | BB/M011224/1, MR/K01014X/1 |
| European Research Council | ERC-COG 101001062 |
| Alfred Benzon Foundation | VIDI-452-16-015 |
| IDEXLYON IMPULSION 2020 | ANR-11-LABX-0042, IDEX/IMP/2020/14 |
| Cancer Research UK | C5255/A15935 |
| Medical Research Council | 203139/Z/16/Z, MR/K02213X/1 |
