The divisome at 25: the road ahead

Tanneke den Blaauwen, Leendert W. Hamoen, Petra Anne Levin

Research output: Contribution to JournalReview articleAcademicpeer-review


The identification of the FtsZ ring by Bi and Lutkenhaus in 1991 was a defining moment for the field of bacterial cell division. Not only did the presence of the FtsZ ring provide fodder for the next 25 years of research, the application of a then cutting-edge approach—immunogold labeling of bacterial cells—inspired other investigators to apply similarly state-of-the-art technologies in their own work. These efforts have led to important advances in our understanding of the factors underlying assembly and maintenance of the division machinery. At the same time, significant questions about the mechanisms coordinating division with cell growth, DNA replication, and chromosome segregation remain. This review addresses the most prominent of these questions, setting the stage for the next 25 years.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalCurrent Opinion in Microbiology
Publication statusPublished - 1 Apr 2017
Externally publishedYes


FundersFunder number
National Institute of General Medical SciencesR01GM064671


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