TY - JOUR
T1 - The divisome at 25
T2 - the road ahead
AU - den Blaauwen, Tanneke
AU - Hamoen, Leendert W.
AU - Levin, Petra Anne
PY - 2017/4/1
Y1 - 2017/4/1
N2 - The identification of the FtsZ ring by Bi and Lutkenhaus in 1991 was a defining moment for the field of bacterial cell division. Not only did the presence of the FtsZ ring provide fodder for the next 25 years of research, the application of a then cutting-edge approach—immunogold labeling of bacterial cells—inspired other investigators to apply similarly state-of-the-art technologies in their own work. These efforts have led to important advances in our understanding of the factors underlying assembly and maintenance of the division machinery. At the same time, significant questions about the mechanisms coordinating division with cell growth, DNA replication, and chromosome segregation remain. This review addresses the most prominent of these questions, setting the stage for the next 25 years.
AB - The identification of the FtsZ ring by Bi and Lutkenhaus in 1991 was a defining moment for the field of bacterial cell division. Not only did the presence of the FtsZ ring provide fodder for the next 25 years of research, the application of a then cutting-edge approach—immunogold labeling of bacterial cells—inspired other investigators to apply similarly state-of-the-art technologies in their own work. These efforts have led to important advances in our understanding of the factors underlying assembly and maintenance of the division machinery. At the same time, significant questions about the mechanisms coordinating division with cell growth, DNA replication, and chromosome segregation remain. This review addresses the most prominent of these questions, setting the stage for the next 25 years.
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U2 - 10.1016/j.mib.2017.01.007
DO - 10.1016/j.mib.2017.01.007
M3 - Review article
C2 - 28254403
AN - SCOPUS:85013878122
SN - 1369-5274
VL - 36
SP - 85
EP - 94
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -