The ecotoxicogenomic assessment of soil toxicity associated with the production chain of 2,5-furandicarboxylic acid (FDCA), a candidate bio-based green chemical building block

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2,5-Furan dicarboxylic acid (FDCA) is one of the top-12 value-added chemicals derived from biomass that may serve as a 'green' substitute for terephthalic acid (TPA) in polyesters. FDCA can be synthesized chemically from 5-(hydroxymethyl)furfural (HMF), which is produced from fructose or glucose. To investigate the impact of the production chain of FDCA on the terrestrial ecosystem and unravel molecular pathways affected in animals, an ecotoxicogenomic study was performed to measure the transcriptome-wide response in soil invertebrates, namely Folsomia candida. First, we show that FDCA, HMF and TPA are biodegradable in natural soil. However, these chemicals can exert severe impact on the reproduction of F. candida in sterilized soil. Transcriptional changes were examined at EC
Original languageEnglish
Pages (from-to)4420-4431
JournalGreen Chemistry
Publication statusPublished - 2016


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