The effect of histamine on the oxidative burst of HL60 cells before and after exposure to reactive oxygen species.

T.L. Ching; J.G. Koelemij; A. Bast

doi:10.1007/BF01782018

The effect of histamine on the oxidative burst of HL60 cells before and after exposure to reactive oxygen species.

T.L. Ching, J.G. Koelemij, A. Bast

Medicinal chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

During an inflammation neutrophils are stimulated to produce reactive oxygen species (ROS). These ROS induce the release of histamine from mast cells, which are also present at the inflammation site. In this study dibutyryl cAMP differentiated HL60 cells are used as a model for human neutrophils. The effect of histamine on formyl-methionyl-leucyl-phenylalanine (fmlp) stimulated cells is examined. Except for histamine also an accumulation of ROS takes place at the inflammation site and we investigated if ROS can influence the response of the stimulated HL60 cells. It is found that 10

Original language	English
Pages (from-to)	99-104
Journal	Inflammation Research
Volume	44
DOIs	https://doi.org/10.1007/BF01782018
Publication status	Published - 1995

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title = "The effect of histamine on the oxidative burst of HL60 cells before and after exposure to reactive oxygen species.",

abstract = "During an inflammation neutrophils are stimulated to produce reactive oxygen species (ROS). These ROS induce the release of histamine from mast cells, which are also present at the inflammation site. In this study dibutyryl cAMP differentiated HL60 cells are used as a model for human neutrophils. The effect of histamine on formyl-methionyl-leucyl-phenylalanine (fmlp) stimulated cells is examined. Except for histamine also an accumulation of ROS takes place at the inflammation site and we investigated if ROS can influence the response of the stimulated HL60 cells. It is found that 10",

author = "T.L. Ching and J.G. Koelemij and A. Bast",

year = "1995",

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journal = "Inflammation Research",

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AU - Ching, T.L.

AU - Koelemij, J.G.

AU - Bast, A.

PY - 1995

Y1 - 1995

N2 - During an inflammation neutrophils are stimulated to produce reactive oxygen species (ROS). These ROS induce the release of histamine from mast cells, which are also present at the inflammation site. In this study dibutyryl cAMP differentiated HL60 cells are used as a model for human neutrophils. The effect of histamine on formyl-methionyl-leucyl-phenylalanine (fmlp) stimulated cells is examined. Except for histamine also an accumulation of ROS takes place at the inflammation site and we investigated if ROS can influence the response of the stimulated HL60 cells. It is found that 10

AB - During an inflammation neutrophils are stimulated to produce reactive oxygen species (ROS). These ROS induce the release of histamine from mast cells, which are also present at the inflammation site. In this study dibutyryl cAMP differentiated HL60 cells are used as a model for human neutrophils. The effect of histamine on formyl-methionyl-leucyl-phenylalanine (fmlp) stimulated cells is examined. Except for histamine also an accumulation of ROS takes place at the inflammation site and we investigated if ROS can influence the response of the stimulated HL60 cells. It is found that 10

U2 - 10.1007/BF01782018

DO - 10.1007/BF01782018

M3 - Article

SN - 1023-3830

VL - 44

SP - 99

EP - 104

JO - Inflammation Research

JF - Inflammation Research

ER -

The effect of histamine on the oxidative burst of HL60 cells before and after exposure to reactive oxygen species.

Abstract

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