The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users

Mieke H J Schulte; Anne Marije Kaag; Wouter J Boendermaker; Wim van den Brink; Anna E Goudriaan; Reinout W Wiers

doi:10.1016/j.pscychresns.2019.03.011

The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users

Mieke H J Schulte^*, Anne Marije Kaag, Wouter J Boendermaker, Wim van den Brink, Anna E Goudriaan, Reinout W Wiers

^*Corresponding author for this work

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Abstract

The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.

Original language	English
Pages (from-to)	56-59
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	287
Early online date	5 Apr 2019
DOIs	https://doi.org/10.1016/j.pscychresns.2019.03.011
Publication status	Published - 30 May 2019

Keywords

Acetylcysteine/pharmacology
Brain/drug effects
Cocaine/adverse effects
Cocaine-Related Disorders/physiopathology
Cognition
Cues
Double-Blind Method
Humans
Male
Memory, Short-Term

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pscychresns.2019.03.011

The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine usersFinal published version, 185 KBLicence: Article 25fa Dutch Copyright Act

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title = "The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users",

abstract = "The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.",

keywords = "Acetylcysteine/pharmacology, Brain/drug effects, Cocaine/adverse effects, Cocaine-Related Disorders/physiopathology, Cognition, Cues, Double-Blind Method, Humans, Male, Memory, Short-Term",

author = "Schulte, {Mieke H J} and Kaag, {Anne Marije} and Boendermaker, {Wouter J} and Brink, {Wim van den} and Goudriaan, {Anna E} and Wiers, {Reinout W}",

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AU - Schulte, Mieke H J

AU - Kaag, Anne Marije

AU - Boendermaker, Wouter J

AU - Brink, Wim van den

AU - Goudriaan, Anna E

AU - Wiers, Reinout W

PY - 2019/5/30

Y1 - 2019/5/30

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AB - The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.

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KW - Brain/drug effects

KW - Cocaine/adverse effects

KW - Cocaine-Related Disorders/physiopathology

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KW - Cues

KW - Double-Blind Method

KW - Humans

KW - Male

KW - Memory, Short-Term

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The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users

Abstract

Keywords

UN SDGs

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