Abstract
The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.
| Original language | English |
|---|---|
| Pages (from-to) | 56-59 |
| Number of pages | 4 |
| Journal | Psychiatry Research - Neuroimaging |
| Volume | 287 |
| Early online date | 5 Apr 2019 |
| DOIs | |
| Publication status | Published - 30 May 2019 |
Funding
The authors would like to thank Denise S. van Deursen of the Psychology department of the University of Amsterdam and Prof. dr. Malte Friese of the Psychology department of the Saarland University for designing the visuo-spatial WM-task that was used in the WM-training of the current study. Funding for this study was provided by grant 022.003.038 from NWO ( Dutch National Science Foundation) , awarded to the Dutch-Flemish Research School Experimental Psychopathology.
| Funders | Funder number |
|---|---|
| Dutch-Flemish Research School Experimental Psychopathology | |
| Nederlandse Organisatie voor Wetenschappelijk Onderzoek | 022.003.038 |
Keywords
- Acetylcysteine/pharmacology
- Brain/drug effects
- Cocaine/adverse effects
- Cocaine-Related Disorders/physiopathology
- Cognition
- Cues
- Double-Blind Method
- Humans
- Male
- Memory, Short-Term
