The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users

Mieke H.J. Schulte, Anne Marije Kaag, Wouter J. Boendermaker, Wim van den Brink, Anna E. Goudriaan, Reinout W. Wiers

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalPsychiatry Research - Neuroimaging
Volume287
Early online date5 Apr 2019
DOIs
Publication statusPublished - 30 May 2019

Fingerprint

Acetylcysteine
Cocaine
Short-Term Memory
Cues
Learning
Sample Size
Placebos
Brain

Keywords

  • Functional magnetic resonance imaging
  • Interventions
  • Substance use disorders

Cite this

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The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users. / Schulte, Mieke H.J.; Kaag, Anne Marije; Boendermaker, Wouter J.; Brink, Wim van den; Goudriaan, Anna E.; Wiers, Reinout W.

In: Psychiatry Research - Neuroimaging, Vol. 287, 30.05.2019, p. 56-59.

Research output: Contribution to JournalArticleAcademicpeer-review

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