The effect of N-acetylcysteine and working memory training on neural mechanisms of working memory and cue reactivity in regular cocaine users

Mieke H J Schulte*, Anne Marije Kaag, Wouter J Boendermaker, Wim van den Brink, Anna E Goudriaan, Reinout W Wiers

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalPsychiatry Research - Neuroimaging
Volume287
Early online date5 Apr 2019
DOIs
Publication statusPublished - 30 May 2019

Keywords

  • Acetylcysteine/pharmacology
  • Brain/drug effects
  • Cocaine/adverse effects
  • Cocaine-Related Disorders/physiopathology
  • Cognition
  • Cues
  • Double-Blind Method
  • Humans
  • Male
  • Memory, Short-Term

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