Abstract
The current study investigated the combined effects of N-acetylcysteine and working memory (WM) training on behavioral and neural mechanisms of cue reactivity and WM in cocaine users in a randomized, double-blind design. Twenty-four of 38 cocaine-using men completed a 25-day treatment with either 2400 mg/day NAC or placebo. Both groups performed WM-training. During pre- and post-test lab-visits, neural mechanisms of cue reactivity and WM, and cue-induced craving and WM performance were assessed. Additionally, exploratory whole brain analyses were performed. Overall, the hypotheses were not confirmed, possibly due to small sample size, low WM-training adherence and/or ongoing substance use.
Original language | English |
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Pages (from-to) | 56-59 |
Number of pages | 4 |
Journal | Psychiatry Research - Neuroimaging |
Volume | 287 |
Early online date | 5 Apr 2019 |
DOIs | |
Publication status | Published - 30 May 2019 |
Keywords
- Acetylcysteine/pharmacology
- Brain/drug effects
- Cocaine/adverse effects
- Cocaine-Related Disorders/physiopathology
- Cognition
- Cues
- Double-Blind Method
- Humans
- Male
- Memory, Short-Term