The effect of nasal application of cocaine/adrenaline on blood loss in Le Fort I osteotomies

J. de Lange; E.M. Baas; R.B.G. Horsthuis; A. Booij

doi:10.1016/j.ijom.2007.07.017

The effect of nasal application of cocaine/adrenaline on blood loss in Le Fort I osteotomies

J. de Lange, E.M. Baas, R.B.G. Horsthuis, A. Booij

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Cocaine is a very potent vasoconstrictor that is used by ENT specialists to reduce blood loss and enhance visibility during nasal surgery. In orthognathic surgery, especially Le Fort I procedures, excessive blood loss is a relatively frequent complication. In this study, a prospective randomized clinical trial on the effect on blood loss of cocaine/adrenaline application to the nasal floor is presented. Thirty patients who underwent a Le Fort I procedure were randomized for cocaine/adrenaline application. Blood loss and duration of surgery were registered for both groups. The results showed a significant reduction of blood loss in the group with cocaine/adrenaline application (P < 0.001), but no significant difference in operating time. No side effects were observed. From this study, it can be concluded that the application of cocaine/adrenaline to the nasal floor is a safe procedure to reduce blood loss during a Le Fort I procedure.

Original language	Undefined/Unknown
Pages (from-to)	21-24
Journal	International Journal of Oral and Maxillofacial Surgery
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.ijom.2007.07.017
Publication status	Published - 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijom.2007.07.017

Persistent URL (handle)

Persistent link

Cite this

@article{19327c61964b4c7a95445146254fa853,

title = "The effect of nasal application of cocaine/adrenaline on blood loss in Le Fort I osteotomies",

abstract = "Cocaine is a very potent vasoconstrictor that is used by ENT specialists to reduce blood loss and enhance visibility during nasal surgery. In orthognathic surgery, especially Le Fort I procedures, excessive blood loss is a relatively frequent complication. In this study, a prospective randomized clinical trial on the effect on blood loss of cocaine/adrenaline application to the nasal floor is presented. Thirty patients who underwent a Le Fort I procedure were randomized for cocaine/adrenaline application. Blood loss and duration of surgery were registered for both groups. The results showed a significant reduction of blood loss in the group with cocaine/adrenaline application (P < 0.001), but no significant difference in operating time. No side effects were observed. From this study, it can be concluded that the application of cocaine/adrenaline to the nasal floor is a safe procedure to reduce blood loss during a Le Fort I procedure.",

author = "{de Lange}, J. and E.M. Baas and R.B.G. Horsthuis and A. Booij",

year = "2008",

doi = "10.1016/j.ijom.2007.07.017",

language = "Undefined/Unknown",

volume = "37",

pages = "21--24",

journal = "International Journal of Oral and Maxillofacial Surgery",

issn = "0901-5027",

publisher = "Churchill Livingstone",

number = "1",

}

TY - JOUR

T1 - The effect of nasal application of cocaine/adrenaline on blood loss in Le Fort I osteotomies

AU - de Lange, J.

AU - Baas, E.M.

AU - Horsthuis, R.B.G.

AU - Booij, A.

PY - 2008

Y1 - 2008

N2 - Cocaine is a very potent vasoconstrictor that is used by ENT specialists to reduce blood loss and enhance visibility during nasal surgery. In orthognathic surgery, especially Le Fort I procedures, excessive blood loss is a relatively frequent complication. In this study, a prospective randomized clinical trial on the effect on blood loss of cocaine/adrenaline application to the nasal floor is presented. Thirty patients who underwent a Le Fort I procedure were randomized for cocaine/adrenaline application. Blood loss and duration of surgery were registered for both groups. The results showed a significant reduction of blood loss in the group with cocaine/adrenaline application (P < 0.001), but no significant difference in operating time. No side effects were observed. From this study, it can be concluded that the application of cocaine/adrenaline to the nasal floor is a safe procedure to reduce blood loss during a Le Fort I procedure.

AB - Cocaine is a very potent vasoconstrictor that is used by ENT specialists to reduce blood loss and enhance visibility during nasal surgery. In orthognathic surgery, especially Le Fort I procedures, excessive blood loss is a relatively frequent complication. In this study, a prospective randomized clinical trial on the effect on blood loss of cocaine/adrenaline application to the nasal floor is presented. Thirty patients who underwent a Le Fort I procedure were randomized for cocaine/adrenaline application. Blood loss and duration of surgery were registered for both groups. The results showed a significant reduction of blood loss in the group with cocaine/adrenaline application (P < 0.001), but no significant difference in operating time. No side effects were observed. From this study, it can be concluded that the application of cocaine/adrenaline to the nasal floor is a safe procedure to reduce blood loss during a Le Fort I procedure.

U2 - 10.1016/j.ijom.2007.07.017

DO - 10.1016/j.ijom.2007.07.017

M3 - Article

SN - 0901-5027

VL - 37

SP - 21

EP - 24

JO - International Journal of Oral and Maxillofacial Surgery

JF - International Journal of Oral and Maxillofacial Surgery

IS - 1

ER -