Abstract
Aim: “Host modulatory therapy” (HMT) with ω-3 fatty acids aims at reducing inflammation. With HMT as an adjunct, a better result of periodontal therapy is expected. The aim of this systematic review and meta-analysis (MA) was to examine the additional effect of ω-3 fatty acids to non-surgical periodontal therapy (SRP) on the probing pocket depth (PPD) and the clinical attachment level (CAL). Materials and Methods: MEDLINE-PubMed and Cochrane-CENTRAL libraries were searched up to January 2021 for randomized controlled trials in patients with chronic periodontitis, treated with SRP/placebo as controls and SRP/ω-3 fatty acids as the test group. Results: The search identified 173 unique abstracts, and screening resulted in 10 eligible publications. Descriptive analysis showed a significant effect on the PPD and CAL in favour of the groups with ω-3 fatty acids in the majority of comparisons. MA revealed that adjunctive use of ω-3 fatty acids to SRP resulted in 0.39 mm more PPD reduction (95% CI: −0.58; −0.21) and 0.41 mm more CAL gain (95% CI: −0.63; −0.19) than SRP alone. Conclusions: In patients with periodontitis, dietary supplementation with ω-3 fatty acids as an adjunct to SRP is more effective in reducing the PPD and improving the CAL than SRP alone. If SRP is indicated, the use of ω-3 fatty acids can be considered for a moderate extra added effect on PPD reduction and CAL gain. The strength of this recommendation is moderate.
| Original language | English |
|---|---|
| Pages (from-to) | 1024-1037 |
| Number of pages | 14 |
| Journal | Journal of Clinical Periodontology |
| Volume | 49 |
| Issue number | 10 |
| Early online date | 17 Jun 2022 |
| DOIs | |
| Publication status | Published - Oct 2022 |
Bibliographical note
Funding Information:The authors declare that they have no conflicts of interest. This research received no specific grant from any funding agency in the public, commercial, or not‐for‐profit sectors. The work for this paper was funded by the regular academic appointments of Timmerman, Brouwer at the Radboud University and Slot at the Academic Centre for Dentistry Amsterdam (ACTA). This paper was prepared as a part of the obligation of the first author Ravensteijn to fulfill the requirements of the Raboud University masters’s program in Dentistry.
Funding Information:
The work for this study was funded by the regular academic appointments of Timmerman, Brouwer at the Radboud University, and Slot at the Academic Centre for Dentistry Amsterdam (ACTA). This paper was prepared as a part of the obligation of the first author Ravensteijn to fulfil the requirements of the Raboud University master's programme in Dentistry.
Publisher Copyright:
© 2022 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.
Funding
The authors declare that they have no conflicts of interest. This research received no specific grant from any funding agency in the public, commercial, or not‐for‐profit sectors. The work for this paper was funded by the regular academic appointments of Timmerman, Brouwer at the Radboud University and Slot at the Academic Centre for Dentistry Amsterdam (ACTA). This paper was prepared as a part of the obligation of the first author Ravensteijn to fulfill the requirements of the Raboud University masters’s program in Dentistry. The work for this study was funded by the regular academic appointments of Timmerman, Brouwer at the Radboud University, and Slot at the Academic Centre for Dentistry Amsterdam (ACTA). This paper was prepared as a part of the obligation of the first author Ravensteijn to fulfil the requirements of the Raboud University master's programme in Dentistry.
Keywords
- DHA
- EPA
- omega-3
- periodontal therapy
- periodontal treatment
