The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: results of a Dutch twin study

P. de Knijff, D.I. Boomsma, E. de Wit, H.J.M. Kempen, J.A. Gevers-Leuven, R.R. Frants, L.M. Havekes

Research output: Contribution to JournalArticleAcademicpeer-review

176 Downloads (Pure)

Abstract

We tested the influence of the apolipoprotein E (apoE) polymorphism on the intrapair differences in the levels of plasma cholesterol, plasma triglycerides, low density lipoprotein-cholesterol, apoB and apoE in monozygotic (MZ) twins, and estimated whether or not there was a interaction between the apoE polymorphism and environmental factors. In 65 MZ twin pairs, the intrapair differences in the measured lipoprotein parameters were similar in the different apoE phenotype classes. This indicates that the effect of the apoE polymorphism is not influenced by environmental variability between the MZ pair members and accordingly identifies the APOE gene as a "level" gene. © 1993 Springer-Verlag.
Original languageEnglish
Pages (from-to)268-272
JournalHuman Genetics
Volume91
Issue number3
DOIs
Publication statusPublished - 1993

Cohort Studies

  • Netherlands Twin Register (NTR)

Fingerprint

Dive into the research topics of 'The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: results of a Dutch twin study'. Together they form a unique fingerprint.

Cite this