The effect of vitamin D on bone and osteoporosis

P.T.A.M. Lips, N.M. van Schoor

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    The main effect of the active vitamin D metabolite 1,25(OH)2D is to stimulate the absorption of calcium from the gut. The consequences of vitamin D deficiency are secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures, mineralization defects, which may lead to osteomalacia in the long term, and muscle weakness, causing falls and fractures. Vitamin D status is related to bone mineral density and bone turnover. Vitamin D supplementation may decrease bone turnover and increase bone mineral density. Several randomized placebo-controlled trials with vitamin D and calcium showed a significant decrease in fracture incidence. However, very high doses of vitamin D once per year may have adverse effects. When patients with osteoporosis are treated with a bisphosphonate, they should receive a vitamin D and calcium supplement unless the patient is vitamin D replete. These subjects are discussed in detail in this review. Finally, the knowledge gaps and research agenda are discussed. © 2010 Elsevier Masson SAS. All rights reserved.
    Original languageEnglish
    Pages (from-to)585-591
    JournalBaillière's Best Practice and Research. Clinical Endocrinology and Metabolism
    Volume25
    Issue number4
    DOIs
    Publication statusPublished - 2011

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