The effects of long-term daily folic acid and vitamin B-12 supplementation on genome-wide DNA methylation in elderly subjects

D.E.G. Kok, R.A.M. Dhonukshe-Rutten, C. Lute, S.G. Heil, A. G. Uitterlinden, N. van der Velde, J.B.J. van Meurs, N.M. van Schoor, G.J.E.J. Hooiveld, L.C.P.G. de Groot, E. Kampman, W.T. Steegenga

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation can be altered via B-vitamins later in life, and how this relates to health and disease, is not exactly known. The aim of this study was to identify effects of long-term supplementation with folic acid and vitamin B
Original languageEnglish
Article number121
JournalClinical epigenetics
Volume7
DOIs
Publication statusPublished - 2015

Fingerprint Dive into the research topics of 'The effects of long-term daily folic acid and vitamin B-12 supplementation on genome-wide DNA methylation in elderly subjects'. Together they form a unique fingerprint.

Cite this