The effects of long-term daily folic acid and vitamin B-12 supplementation on genome-wide DNA methylation in elderly subjects

D.E.G. Kok; R.A.M. Dhonukshe-Rutten; C. Lute; S.G. Heil; A. G. Uitterlinden; N. van der Velde; J.B.J. van Meurs; N.M. van Schoor; G.J.E.J. Hooiveld; L.C.P.G. de Groot; E. Kampman; W.T. Steegenga

doi:10.1186/s13148-015-0154-5

The effects of long-term daily folic acid and vitamin B-12 supplementation on genome-wide DNA methylation in elderly subjects

D.E.G. Kok
, R.A.M. Dhonukshe-Rutten
, C. Lute
, S.G. Heil
, A. G. Uitterlinden
, N. van der Velde
, J.B.J. van Meurs
, N.M. van Schoor
, G.J.E.J. Hooiveld
, L.C.P.G. de Groot
, E. Kampman
, W.T. Steegenga

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation can be altered via B-vitamins later in life, and how this relates to health and disease, is not exactly known. The aim of this study was to identify effects of long-term supplementation with folic acid and vitamin B

Original language	English
Article number	121
Journal	Clinical epigenetics
Volume	7
DOIs	https://doi.org/10.1186/s13148-015-0154-5
Publication status	Published - 2015

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10.1186/s13148-015-0154-5

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Kok, D. E. G., Dhonukshe-Rutten, R. A. M., Lute, C., Heil, S. G., Uitterlinden, A. G., van der Velde, N., van Meurs, J. B. J., van Schoor, N. M., Hooiveld, G. J. E. J., de Groot, L. C. P. G., Kampman, E., & Steegenga, W. T. (2015). The effects of long-term daily folic acid and vitamin B-12 supplementation on genome-wide DNA methylation in elderly subjects. Clinical epigenetics, 7, Article 121. https://doi.org/10.1186/s13148-015-0154-5

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abstract = "Background: Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation can be altered via B-vitamins later in life, and how this relates to health and disease, is not exactly known. The aim of this study was to identify effects of long-term supplementation with folic acid and vitamin B",

author = "D.E.G. Kok and R.A.M. Dhonukshe-Rutten and C. Lute and S.G. Heil and Uitterlinden, \{A. G.\} and \{van der Velde\}, N. and \{van Meurs\}, J.B.J. and \{van Schoor\}, N.M. and G.J.E.J. Hooiveld and \{de Groot\}, L.C.P.G. and E. Kampman and W.T. Steegenga",

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doi = "10.1186/s13148-015-0154-5",

language = "English",

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Kok, DEG, Dhonukshe-Rutten, RAM, Lute, C, Heil, SG, Uitterlinden, AG, van der Velde, N, van Meurs, JBJ, van Schoor, NM, Hooiveld, GJEJ, de Groot, LCPG, Kampman, E & Steegenga, WT 2015, 'The effects of long-term daily folic acid and vitamin B-12 supplementation on genome-wide DNA methylation in elderly subjects', Clinical epigenetics, vol. 7, 121. https://doi.org/10.1186/s13148-015-0154-5

TY - JOUR

T1 - The effects of long-term daily folic acid and vitamin B-12 supplementation on genome-wide DNA methylation in elderly subjects

AU - Kok, D.E.G.

AU - Dhonukshe-Rutten, R.A.M.

AU - Lute, C.

AU - Heil, S.G.

AU - Uitterlinden, A. G.

AU - van der Velde, N.

AU - van Meurs, J.B.J.

AU - van Schoor, N.M.

AU - Hooiveld, G.J.E.J.

AU - de Groot, L.C.P.G.

AU - Kampman, E.

AU - Steegenga, W.T.

PY - 2015

Y1 - 2015

N2 - Background: Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation can be altered via B-vitamins later in life, and how this relates to health and disease, is not exactly known. The aim of this study was to identify effects of long-term supplementation with folic acid and vitamin B

AB - Background: Folate and its synthetic form folic acid function as donor of one-carbon units and have been, together with other B-vitamins, implicated in programming of epigenetic processes such as DNA methylation during early development. To what extent regulation of DNA methylation can be altered via B-vitamins later in life, and how this relates to health and disease, is not exactly known. The aim of this study was to identify effects of long-term supplementation with folic acid and vitamin B

U2 - 10.1186/s13148-015-0154-5

DO - 10.1186/s13148-015-0154-5

M3 - Article

SN - 1868-7083

VL - 7

JO - Clinical epigenetics

JF - Clinical epigenetics

M1 - 121

ER -

The effects of long-term daily folic acid and vitamin B-12 supplementation on genome-wide DNA methylation in elderly subjects

Abstract

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