The efficacy of Life Review Therapy combined with Memory Specificity training (LRT-MST) in advanced cancer patients: a randomized controlled trial.

G. Kleijn, B.I. Witte , E.T. Bohlmeijer, B. Steunenberg, K. Knipscheer, V. Willemsen, A. Becker, E.F. Smit, C.M. Eeltink, A.M.E. Bruynzeel, M. van der Vorst, M. de Bree, C.R. Leemans, M.W.M. van den Brekel, P. Cuijpers, I.M. Verdonck-de Leeuw

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background
The aim of this study was to evaluate the efficacy of an intervention combining Life Review Therapy (LRT) and Memory Specificity Training (MST) (LRT-MST) to improve ego-integrity and despair among cancer patients in palliative care.
Methods
In this multicentre randomized controlled trial, cancer patients in palliative care were randomized to the intervention group (LRT-MST; n = 55) or waiting-list control group (n = 52). LRT-MST is a 4-session home-based psychological intervention that aims to retrieve specific positive memories, to re-evaluate life events and to reconstruct the story of a patient’s life, including the diagnosis of incurable cancer. Outcome measures were ego-integrity and despair (NEIS), psychological distress, anxiety and depression (HADS), quality of life (EORTC QLQ-C15-PAL), and specificity of the autobiographical memory (AMT). NEIS, HADS and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment; T1), and at 1 month follow-up (T2). AMT was assessed at T0 and T1. Linear mixed models (intention to treat) were used to assess group differences in changes over time. Independent samples t-tests were used to assess group differences at T0, T1, and T2, and effect sizes (ES) were calculated at T1 and T2.
Results
The course of ego-integrity (not despair) improved significantly over time (p = .007) in the intervention group compared to the waiting-list control group, with moderate, but insignificant, effect sizes at T1 (ES = .42) and T2 (ES = .48). Compliance rate was 69% and total dropout rate was 28%, both primarily related to disease progression and death.
Conclusions
LRT-MST seems effective among cancer patients in palliative care to improve the course of ego-integrity.
Original languageEnglish
Article numbere0197277
Pages (from-to)1-13
Number of pages13
JournalPLoS ONE
Volume13
Issue number5
DOIs
Publication statusPublished - 15 May 2018

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Ego
Randomized Controlled Trials
Learning
Data storage equipment
therapeutics
neoplasms
patient care
Palliative Care
Neoplasms
Waiting Lists
Therapeutics
Psychology
Control Groups
Episodic Memory
dropouts
life events
anxiety
distress
Disease Progression
quality of life

Cite this

Kleijn, G. ; Witte , B.I. ; Bohlmeijer, E.T. ; Steunenberg, B. ; Knipscheer, K. ; Willemsen, V. ; Becker, A. ; Smit, E.F. ; Eeltink, C.M. ; Bruynzeel, A.M.E. ; van der Vorst, M. ; de Bree, M. ; Leemans, C.R. ; van den Brekel, M.W.M. ; Cuijpers, P. ; Verdonck-de Leeuw, I.M. / The efficacy of Life Review Therapy combined with Memory Specificity training (LRT-MST) in advanced cancer patients: a randomized controlled trial. In: PLoS ONE. 2018 ; Vol. 13, No. 5. pp. 1-13.
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title = "The efficacy of Life Review Therapy combined with Memory Specificity training (LRT-MST) in advanced cancer patients: a randomized controlled trial.",
abstract = "BackgroundThe aim of this study was to evaluate the efficacy of an intervention combining Life Review Therapy (LRT) and Memory Specificity Training (MST) (LRT-MST) to improve ego-integrity and despair among cancer patients in palliative care.MethodsIn this multicentre randomized controlled trial, cancer patients in palliative care were randomized to the intervention group (LRT-MST; n = 55) or waiting-list control group (n = 52). LRT-MST is a 4-session home-based psychological intervention that aims to retrieve specific positive memories, to re-evaluate life events and to reconstruct the story of a patient’s life, including the diagnosis of incurable cancer. Outcome measures were ego-integrity and despair (NEIS), psychological distress, anxiety and depression (HADS), quality of life (EORTC QLQ-C15-PAL), and specificity of the autobiographical memory (AMT). NEIS, HADS and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment; T1), and at 1 month follow-up (T2). AMT was assessed at T0 and T1. Linear mixed models (intention to treat) were used to assess group differences in changes over time. Independent samples t-tests were used to assess group differences at T0, T1, and T2, and effect sizes (ES) were calculated at T1 and T2.ResultsThe course of ego-integrity (not despair) improved significantly over time (p = .007) in the intervention group compared to the waiting-list control group, with moderate, but insignificant, effect sizes at T1 (ES = .42) and T2 (ES = .48). Compliance rate was 69{\%} and total dropout rate was 28{\%}, both primarily related to disease progression and death.ConclusionsLRT-MST seems effective among cancer patients in palliative care to improve the course of ego-integrity.",
author = "G. Kleijn and B.I. Witte and E.T. Bohlmeijer and B. Steunenberg and K. Knipscheer and V. Willemsen and A. Becker and E.F. Smit and C.M. Eeltink and A.M.E. Bruynzeel and {van der Vorst}, M. and {de Bree}, M. and C.R. Leemans and {van den Brekel}, M.W.M. and P. Cuijpers and {Verdonck-de Leeuw}, I.M.",
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doi = "10.1371/journal.pone.0197277",
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Kleijn, G, Witte , BI, Bohlmeijer, ET, Steunenberg, B, Knipscheer, K, Willemsen, V, Becker, A, Smit, EF, Eeltink, CM, Bruynzeel, AME, van der Vorst, M, de Bree, M, Leemans, CR, van den Brekel, MWM, Cuijpers, P & Verdonck-de Leeuw, IM 2018, 'The efficacy of Life Review Therapy combined with Memory Specificity training (LRT-MST) in advanced cancer patients: a randomized controlled trial.' PLoS ONE, vol. 13, no. 5, e0197277, pp. 1-13. https://doi.org/10.1371/journal.pone.0197277

The efficacy of Life Review Therapy combined with Memory Specificity training (LRT-MST) in advanced cancer patients: a randomized controlled trial. / Kleijn, G.; Witte , B.I.; Bohlmeijer, E.T.; Steunenberg, B.; Knipscheer, K.; Willemsen, V.; Becker, A.; Smit, E.F.; Eeltink, C.M.; Bruynzeel, A.M.E.; van der Vorst, M.; de Bree, M.; Leemans, C.R.; van den Brekel, M.W.M.; Cuijpers, P.; Verdonck-de Leeuw, I.M.

In: PLoS ONE, Vol. 13, No. 5, e0197277, 15.05.2018, p. 1-13.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - The efficacy of Life Review Therapy combined with Memory Specificity training (LRT-MST) in advanced cancer patients: a randomized controlled trial.

AU - Kleijn, G.

AU - Witte , B.I.

AU - Bohlmeijer, E.T.

AU - Steunenberg, B.

AU - Knipscheer, K.

AU - Willemsen, V.

AU - Becker, A.

AU - Smit, E.F.

AU - Eeltink, C.M.

AU - Bruynzeel, A.M.E.

AU - van der Vorst, M.

AU - de Bree, M.

AU - Leemans, C.R.

AU - van den Brekel, M.W.M.

AU - Cuijpers, P.

AU - Verdonck-de Leeuw, I.M.

PY - 2018/5/15

Y1 - 2018/5/15

N2 - BackgroundThe aim of this study was to evaluate the efficacy of an intervention combining Life Review Therapy (LRT) and Memory Specificity Training (MST) (LRT-MST) to improve ego-integrity and despair among cancer patients in palliative care.MethodsIn this multicentre randomized controlled trial, cancer patients in palliative care were randomized to the intervention group (LRT-MST; n = 55) or waiting-list control group (n = 52). LRT-MST is a 4-session home-based psychological intervention that aims to retrieve specific positive memories, to re-evaluate life events and to reconstruct the story of a patient’s life, including the diagnosis of incurable cancer. Outcome measures were ego-integrity and despair (NEIS), psychological distress, anxiety and depression (HADS), quality of life (EORTC QLQ-C15-PAL), and specificity of the autobiographical memory (AMT). NEIS, HADS and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment; T1), and at 1 month follow-up (T2). AMT was assessed at T0 and T1. Linear mixed models (intention to treat) were used to assess group differences in changes over time. Independent samples t-tests were used to assess group differences at T0, T1, and T2, and effect sizes (ES) were calculated at T1 and T2.ResultsThe course of ego-integrity (not despair) improved significantly over time (p = .007) in the intervention group compared to the waiting-list control group, with moderate, but insignificant, effect sizes at T1 (ES = .42) and T2 (ES = .48). Compliance rate was 69% and total dropout rate was 28%, both primarily related to disease progression and death.ConclusionsLRT-MST seems effective among cancer patients in palliative care to improve the course of ego-integrity.

AB - BackgroundThe aim of this study was to evaluate the efficacy of an intervention combining Life Review Therapy (LRT) and Memory Specificity Training (MST) (LRT-MST) to improve ego-integrity and despair among cancer patients in palliative care.MethodsIn this multicentre randomized controlled trial, cancer patients in palliative care were randomized to the intervention group (LRT-MST; n = 55) or waiting-list control group (n = 52). LRT-MST is a 4-session home-based psychological intervention that aims to retrieve specific positive memories, to re-evaluate life events and to reconstruct the story of a patient’s life, including the diagnosis of incurable cancer. Outcome measures were ego-integrity and despair (NEIS), psychological distress, anxiety and depression (HADS), quality of life (EORTC QLQ-C15-PAL), and specificity of the autobiographical memory (AMT). NEIS, HADS and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment; T1), and at 1 month follow-up (T2). AMT was assessed at T0 and T1. Linear mixed models (intention to treat) were used to assess group differences in changes over time. Independent samples t-tests were used to assess group differences at T0, T1, and T2, and effect sizes (ES) were calculated at T1 and T2.ResultsThe course of ego-integrity (not despair) improved significantly over time (p = .007) in the intervention group compared to the waiting-list control group, with moderate, but insignificant, effect sizes at T1 (ES = .42) and T2 (ES = .48). Compliance rate was 69% and total dropout rate was 28%, both primarily related to disease progression and death.ConclusionsLRT-MST seems effective among cancer patients in palliative care to improve the course of ego-integrity.

U2 - 10.1371/journal.pone.0197277

DO - 10.1371/journal.pone.0197277

M3 - Article

VL - 13

SP - 1

EP - 13

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 5

M1 - e0197277

ER -