The emerging role of the histamine H4 receptor in anti-inflammatory therapy

Herman D Lim, Rogier A Smits, Rob Leurs, Iwan J P De Esch

Research output: Contribution to JournalReview articleAcademicpeer-review


Antagonists for the Histamine H(1) receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H(4) receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H(4) receptor as a drug target.

Original languageEnglish
Pages (from-to)1365-73
Number of pages9
JournalCurrent Topics in Medicinal Chemistry
Issue number13
Publication statusPublished - 2006


  • Animals
  • Anti-Inflammatory Agents
  • Drug Design
  • Humans
  • Inflammation
  • Ligands
  • Molecular Structure
  • Neoplasms
  • Receptors, G-Protein-Coupled
  • Receptors, Histamine
  • Structure-Activity Relationship
  • Journal Article
  • Review


Dive into the research topics of 'The emerging role of the histamine H4 receptor in anti-inflammatory therapy'. Together they form a unique fingerprint.

Cite this