The emerging role of the histamine H4 receptor in anti-inflammatory therapy

Herman D Lim, Rogier A Smits, Rob Leurs, Iwan J P De Esch

    Research output: Contribution to JournalReview articleAcademicpeer-review

    Abstract

    Antagonists for the Histamine H(1) receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H(4) receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H(4) receptor as a drug target.

    Original languageEnglish
    Pages (from-to)1365-73
    Number of pages9
    JournalCurrent Topics in Medicinal Chemistry
    Volume6
    Issue number13
    DOIs
    Publication statusPublished - 2006

    Keywords

    • Animals
    • Anti-Inflammatory Agents
    • Drug Design
    • Humans
    • Inflammation
    • Ligands
    • Molecular Structure
    • Neoplasms
    • Receptors, G-Protein-Coupled
    • Receptors, Histamine
    • Structure-Activity Relationship
    • Journal Article
    • Review

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