The emerging role of the histamine H4 receptor in anti-inflammatory therapy

Herman D Lim; Rogier A Smits; Rob Leurs; Iwan J P De Esch

doi:10.2174/15680266106061365

The emerging role of the histamine H4 receptor in anti-inflammatory therapy

Herman D Lim, Rogier A Smits, Rob Leurs, Iwan J P De Esch

Medicinal chemistry

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

Antagonists for the Histamine H(1) receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H(4) receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H(4) receptor as a drug target.

Original language	English
Pages (from-to)	1365-73
Number of pages	9
Journal	Current Topics in Medicinal Chemistry
Volume	6
Issue number	13
DOIs	https://doi.org/10.2174/15680266106061365
Publication status	Published - 2006

Keywords

Animals
Anti-Inflammatory Agents
Drug Design
Humans
Inflammation
Ligands
Molecular Structure
Neoplasms
Receptors, G-Protein-Coupled
Receptors, Histamine
Structure-Activity Relationship
Journal Article
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The emerging role of the histamine H4 receptor in anti-inflammatory therapy",

abstract = "Antagonists for the Histamine H(1) receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H(4) receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H(4) receptor as a drug target.",

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author = "Lim, {Herman D} and Smits, {Rogier A} and Rob Leurs and {De Esch}, {Iwan J P}",

year = "2006",

doi = "10.2174/15680266106061365",

language = "English",

volume = "6",

pages = "1365--73",

journal = "Current Topics in Medicinal Chemistry",

issn = "1568-0266",

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T1 - The emerging role of the histamine H4 receptor in anti-inflammatory therapy

AU - Lim, Herman D

AU - Smits, Rogier A

AU - Leurs, Rob

AU - De Esch, Iwan J P

PY - 2006

Y1 - 2006

N2 - Antagonists for the Histamine H(1) receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H(4) receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H(4) receptor as a drug target.

AB - Antagonists for the Histamine H(1) receptor have been on the market for decades and continue to be successfully used in the treatment of a variety of allergic conditions. The recently discovered histamine H(4) receptor subtype is emerging as a new and complementary target for treating inflammatory conditions. In this review, we describe the receptor protein, its putative role in (patho)physiology and the latest ligands that are being developed to explore the feasibility of the H(4) receptor as a drug target.

KW - Animals

KW - Anti-Inflammatory Agents

KW - Drug Design

KW - Humans

KW - Inflammation

KW - Ligands

KW - Molecular Structure

KW - Neoplasms

KW - Receptors, G-Protein-Coupled

KW - Receptors, Histamine

KW - Structure-Activity Relationship

KW - Journal Article

KW - Review

U2 - 10.2174/15680266106061365

DO - 10.2174/15680266106061365

M3 - Review article

C2 - 16918455

SN - 1568-0266

VL - 6

SP - 1365

EP - 1373

JO - Current Topics in Medicinal Chemistry

JF - Current Topics in Medicinal Chemistry

IS - 13

ER -

The emerging role of the histamine H4 receptor in anti-inflammatory therapy

Abstract

Keywords

UN SDGs

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