The ENDpoiNTs project: Novel testing strategies for endocrine disruptors linked to developmental neurotoxicity

Diana Lupu; Patrik Andersson; Carl Gustaf Bornehag; Barbara Demeneix; Ellen Fritsche; Chris Gennings; Walter Lichtensteiger; Marcel Leist; Pim E.G. Leonards; Anne Louise Ponsonby; Martin Scholze; Giuseppe Testa; Jesus A.F. Tresguerres; Remco H.S. Westerink; Bernard Zalc; Joëlle Rüegg

doi:10.3390/ijms21113978

The ENDpoiNTs project: Novel testing strategies for endocrine disruptors linked to developmental neurotoxicity

Diana Lupu^*, Patrik Andersson, Carl Gustaf Bornehag, Barbara Demeneix, Ellen Fritsche, Chris Gennings, Walter Lichtensteiger, Marcel Leist, Pim E.G. Leonards, Anne Louise Ponsonby, Martin Scholze, Giuseppe Testa, Jesus A.F. Tresguerres, Remco H.S. Westerink, Bernard Zalc, Joëlle Rüegg

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.

Original language	English
Article number	3978
Pages (from-to)	1-16
Number of pages	16
Journal	International Journal of Molecular Sciences
Volume	21
Issue number	11
DOIs	https://doi.org/10.3390/ijms21113978
Publication status	Published - 1 Jun 2020

Funding

Funding: The ENDpoiNTs project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme, under Grant Agreement number: 825759.

Funders	Funder number
Horizon 2020 Framework Programme	825759
Horizon 2020 Framework Programme

Keywords

Adverse outcome pathways
Chemical testing
Developmental neurotoxicity
Endocrine-disrupting chemicals

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms21113978

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Lupu, D., Andersson, P., Bornehag, C. G., Demeneix, B., Fritsche, E., Gennings, C., Lichtensteiger, W., Leist, M., Leonards, P. E. G., Ponsonby, A. L., Scholze, M., Testa, G., Tresguerres, J. A. F., Westerink, R. H. S., Zalc, B., & Rüegg, J. (2020). The ENDpoiNTs project: Novel testing strategies for endocrine disruptors linked to developmental neurotoxicity. International Journal of Molecular Sciences, 21(11), 1-16. Article 3978. https://doi.org/10.3390/ijms21113978

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abstract = "Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.",

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author = "Diana Lupu and Patrik Andersson and Bornehag, {Carl Gustaf} and Barbara Demeneix and Ellen Fritsche and Chris Gennings and Walter Lichtensteiger and Marcel Leist and Leonards, {Pim E.G.} and Ponsonby, {Anne Louise} and Martin Scholze and Giuseppe Testa and Tresguerres, {Jesus A.F.} and Westerink, {Remco H.S.} and Bernard Zalc and Jo{\"e}lle R{\"u}egg",

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Lupu, D, Andersson, P, Bornehag, CG, Demeneix, B, Fritsche, E, Gennings, C, Lichtensteiger, W, Leist, M, Leonards, PEG, Ponsonby, AL, Scholze, M, Testa, G, Tresguerres, JAF, Westerink, RHS, Zalc, B & Rüegg, J 2020, 'The ENDpoiNTs project: Novel testing strategies for endocrine disruptors linked to developmental neurotoxicity', International Journal of Molecular Sciences, vol. 21, no. 11, 3978, pp. 1-16. https://doi.org/10.3390/ijms21113978

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AU - Lupu, Diana

AU - Andersson, Patrik

AU - Bornehag, Carl Gustaf

AU - Demeneix, Barbara

AU - Fritsche, Ellen

AU - Gennings, Chris

AU - Lichtensteiger, Walter

AU - Leist, Marcel

AU - Leonards, Pim E.G.

AU - Ponsonby, Anne Louise

AU - Scholze, Martin

AU - Testa, Giuseppe

AU - Tresguerres, Jesus A.F.

AU - Westerink, Remco H.S.

AU - Zalc, Bernard

AU - Rüegg, Joëlle

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N2 - Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.

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The ENDpoiNTs project: Novel testing strategies for endocrine disruptors linked to developmental neurotoxicity

Abstract

Funding

Keywords

UN SDGs

Access to Document

Persistent URL (handle)

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