The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

P.M. Thompson, J.L. Stein, S.E. Medland, D.P. Hibar, A. Arias-Vásquez, M.E. Renteria, R. Toro, N. Jahanshad, G. Schumann, B. Franke, M.J. Wright, N.G. Martin, I. Agartz, M. Lopez de Alda, S. Alhusaini, D.I. Boomsma, R.M. Brouwer, E.J.C. de Geus, A. den Braber, I.O. Fedko & 22 others J.J. Hottenga, H.E. Hulshoff Pol, G.W. Montgomery, B.W.J.H. Penninx, Y. Milaneschi, H.G. Schnack, D. van t Ent, L.T. Westlye, H.C. Whalley, C.D. Whelan, T. White, A.M. Winkler, K. Wittfeld, G. Woldehawariat, C. Wolf, D. Zilles, M.P. Zwiers, A. Thalamuthu, P.R. Schofield, N.B. Freimer, N.S. Lawrence, W. Drevets

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. © 2014 The Author(s).
LanguageEnglish
Pages153-182
Number of pages30
JournalBrain Imaging and Behavior
Volume8
Issue number2
DOIs
Publication statusPublished - 2014

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Neuroimaging
Meta-Analysis
Genome-Wide Association Study
Brain
Attention Deficit Disorder with Hyperactivity
Neurosciences
Focus Groups
Schizophrenia
Research Personnel
Medicine
Genome
Depression

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Thompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Arias-Vásquez, A., Renteria, M. E., ... Drevets, W. (2014). The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior, 8(2), 153-182. https://doi.org/10.1007/s11682-013-9269-5
Thompson, P.M. ; Stein, J.L. ; Medland, S.E. ; Hibar, D.P. ; Arias-Vásquez, A. ; Renteria, M.E. ; Toro, R. ; Jahanshad, N. ; Schumann, G. ; Franke, B. ; Wright, M.J. ; Martin, N.G. ; Agartz, I. ; Lopez de Alda, M. ; Alhusaini, S. ; Boomsma, D.I. ; Brouwer, R.M. ; de Geus, E.J.C. ; den Braber, A. ; Fedko, I.O. ; Hottenga, J.J. ; Hulshoff Pol, H.E. ; Montgomery, G.W. ; Penninx, B.W.J.H. ; Milaneschi, Y. ; Schnack, H.G. ; van t Ent, D. ; Westlye, L.T. ; Whalley, H.C. ; Whelan, C.D. ; White, T. ; Winkler, A.M. ; Wittfeld, K. ; Woldehawariat, G. ; Wolf, C. ; Zilles, D. ; Zwiers, M.P. ; Thalamuthu, A. ; Schofield, P.R. ; Freimer, N.B. ; Lawrence, N.S. ; Drevets, W. / The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. In: Brain Imaging and Behavior. 2014 ; Vol. 8, No. 2. pp. 153-182.
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abstract = "The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. {\circledC} 2014 The Author(s).",
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Thompson, PM, Stein, JL, Medland, SE, Hibar, DP, Arias-Vásquez, A, Renteria, ME, Toro, R, Jahanshad, N, Schumann, G, Franke, B, Wright, MJ, Martin, NG, Agartz, I, Lopez de Alda, M, Alhusaini, S, Boomsma, DI, Brouwer, RM, de Geus, EJC, den Braber, A, Fedko, IO, Hottenga, JJ, Hulshoff Pol, HE, Montgomery, GW, Penninx, BWJH, Milaneschi, Y, Schnack, HG, van t Ent, D, Westlye, LT, Whalley, HC, Whelan, CD, White, T, Winkler, AM, Wittfeld, K, Woldehawariat, G, Wolf, C, Zilles, D, Zwiers, MP, Thalamuthu, A, Schofield, PR, Freimer, NB, Lawrence, NS & Drevets, W 2014, 'The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data', Brain Imaging and Behavior, vol. 8, no. 2, pp. 153-182. https://doi.org/10.1007/s11682-013-9269-5

The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. / Thompson, P.M.; Stein, J.L.; Medland, S.E.; Hibar, D.P.; Arias-Vásquez, A.; Renteria, M.E.; Toro, R.; Jahanshad, N.; Schumann, G.; Franke, B.; Wright, M.J.; Martin, N.G.; Agartz, I.; Lopez de Alda, M.; Alhusaini, S.; Boomsma, D.I.; Brouwer, R.M.; de Geus, E.J.C.; den Braber, A.; Fedko, I.O.; Hottenga, J.J.; Hulshoff Pol, H.E.; Montgomery, G.W.; Penninx, B.W.J.H.; Milaneschi, Y.; Schnack, H.G.; van t Ent, D.; Westlye, L.T.; Whalley, H.C.; Whelan, C.D.; White, T.; Winkler, A.M.; Wittfeld, K.; Woldehawariat, G.; Wolf, C.; Zilles, D.; Zwiers, M.P.; Thalamuthu, A.; Schofield, P.R.; Freimer, N.B.; Lawrence, N.S.; Drevets, W.

In: Brain Imaging and Behavior, Vol. 8, No. 2, 2014, p. 153-182.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

AU - Thompson, P.M.

AU - Stein, J.L.

AU - Medland, S.E.

AU - Hibar, D.P.

AU - Arias-Vásquez, A.

AU - Renteria, M.E.

AU - Toro, R.

AU - Jahanshad, N.

AU - Schumann, G.

AU - Franke, B.

AU - Wright, M.J.

AU - Martin, N.G.

AU - Agartz, I.

AU - Lopez de Alda, M.

AU - Alhusaini, S.

AU - Boomsma, D.I.

AU - Brouwer, R.M.

AU - de Geus, E.J.C.

AU - den Braber, A.

AU - Fedko, I.O.

AU - Hottenga, J.J.

AU - Hulshoff Pol, H.E.

AU - Montgomery, G.W.

AU - Penninx, B.W.J.H.

AU - Milaneschi, Y.

AU - Schnack, H.G.

AU - van t Ent, D.

AU - Westlye, L.T.

AU - Whalley, H.C.

AU - Whelan, C.D.

AU - White, T.

AU - Winkler, A.M.

AU - Wittfeld, K.

AU - Woldehawariat, G.

AU - Wolf, C.

AU - Zilles, D.

AU - Zwiers, M.P.

AU - Thalamuthu, A.

AU - Schofield, P.R.

AU - Freimer, N.B.

AU - Lawrence, N.S.

AU - Drevets, W.

PY - 2014

Y1 - 2014

N2 - The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. © 2014 The Author(s).

AB - The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way. © 2014 The Author(s).

U2 - 10.1007/s11682-013-9269-5

DO - 10.1007/s11682-013-9269-5

M3 - Article

VL - 8

SP - 153

EP - 182

JO - Brain Imaging and Behavior

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JF - Brain Imaging and Behavior

SN - 1931-7557

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Thompson PM, Stein JL, Medland SE, Hibar DP, Arias-Vásquez A, Renteria ME et al. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior. 2014;8(2):153-182. https://doi.org/10.1007/s11682-013-9269-5