The genetic and environmental relationship between childhood behavioral inhibition and preadolescent anxiety

Jessica L. Bourdon; Jeanne E. Savage; Brad Verhulst; Dever M. Carney; Melissa A. Brotman; Daniel S. Pine; Ellen Leibenluft; Roxann Roberson-Nay; John M. Hettema

doi:10.1017/thg.2018.73

The genetic and environmental relationship between childhood behavioral inhibition and preadolescent anxiety

Jessica L. Bourdon^*, Jeanne E. Savage, Brad Verhulst, Dever M. Carney, Melissa A. Brotman, Daniel S. Pine, Ellen Leibenluft, Roxann Roberson-Nay, John M. Hettema

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

This study uses novel approaches to examine genetic and environmental influences shared between childhood behavioral inhibition (BI) and symptoms of preadolescent anxiety disorders. Three hundred and fifty-two twin pairs aged 9-13 and their mothers completed questionnaires about BI and anxiety symptoms. Biometrical twin modeling, including a direction-of-causation design, investigated genetic and environmental risk factors shared between BI and social, generalized, panic and separation anxiety. Social anxiety shared the greatest proportion of genetic (20%) and environmental (16%) variance with BI with tentative evidence for causality. Etiological factors underlying BI explained little of the risk associated with the other anxiety domains. Findings further clarify etiologic pathways between BI and anxiety disorder domains in children.

Original language	English
Pages (from-to)	48-55
Number of pages	8
Journal	Twin Research and Human Genetics
Volume	22
Issue number	1
Early online date	30 Jan 2019
DOIs	https://doi.org/10.1017/thg.2018.73
Publication status	Published - Feb 2019

Keywords

anxiety
behavioral inhibition
twins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/thg.2018.73

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449201

Cite this

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AU - Brotman, Melissa A.

AU - Pine, Daniel S.

AU - Leibenluft, Ellen

AU - Roberson-Nay, Roxann

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The genetic and environmental relationship between childhood behavioral inhibition and preadolescent anxiety

Abstract

Keywords

UN SDGs

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