The Genetics of Human DZ Twinning

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In the course of twin studies whose main focus was elucidation of genetic and environmental factors on behavioral traits, many twin researchers became aware of the strong tendency for dizygotic (DZ) twinning to run in families. Over four decades, Nick Martin and others initiated hormone and ultrasound studies, performed segregation and pedigree analyses, tested candidate genes, carried out linkage projects in sister pairs and formed large collaborations to illuminate the genetics of DZ twinning by genome-wide association studies and meta-analysis. This article summarizes the early work on hormone and genetic studies and describes the meta-analyses that have at last met with success in finding the first genes that predispose to DZ twinning, which also appear to influence many other female reproductive traits.

Original languageEnglish
Pages (from-to)74-76
Number of pages3
JournalTwin research and human genetics : the official journal of the International Society for Twin Studies
Issue number2
Publication statusPublished - 8 May 2020

Cohort Studies

  • Netherlands Twin Register (NTR)


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