TY - JOUR
T1 - The global introduction of inactivated polio vaccine can circumvent the oral polio vaccine paradox
AU - Heinsbroek, E.
AU - Ruitenberg, E.J.
PY - 2010
Y1 - 2010
N2 - This literature review identifies the factors that influence the decision to introduce inactivated polio vaccine (IPV) in developing countries as opposed to the policy of vaccine cessation. Attenuated viruses in the oral polio vaccine (OPV) can replicate, revert to neurovirulence and become transmissible circulating vaccine-derived polioviruses (cVDPVs), preventing use of the vaccine in the post-eradication era. This literature review identifies (1) risks of complete cessation of vaccination, (2) barriers and (3) solutions for the introduction of IPV in developing countries. The reviewed literature favours to circumvent the so-called "OPV paradox" by global introduction of IPV. © 2010 Elsevier Ltd. All rights reserved.
AB - This literature review identifies the factors that influence the decision to introduce inactivated polio vaccine (IPV) in developing countries as opposed to the policy of vaccine cessation. Attenuated viruses in the oral polio vaccine (OPV) can replicate, revert to neurovirulence and become transmissible circulating vaccine-derived polioviruses (cVDPVs), preventing use of the vaccine in the post-eradication era. This literature review identifies (1) risks of complete cessation of vaccination, (2) barriers and (3) solutions for the introduction of IPV in developing countries. The reviewed literature favours to circumvent the so-called "OPV paradox" by global introduction of IPV. © 2010 Elsevier Ltd. All rights reserved.
UR - https://www.scopus.com/pages/publications/77952320069
UR - https://www.scopus.com/inward/citedby.url?scp=77952320069&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2010.02.095
DO - 10.1016/j.vaccine.2010.02.095
M3 - Article
SN - 0264-410X
VL - 28
SP - 3778
EP - 3783
JO - Vaccine
JF - Vaccine
IS - 22
ER -
