The heme-copper oxidase family consists of three distinct types of terminal oxidases and is related to nitric oxide reductase

J. van der Oost, A P de Boer, J.-W. de Gier, W.G. Zumft, A.H. Stouthamer, R J van Spanning

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Among aerobic prokaryotes, many different terminal oxidase complexes have been described. Sequence comparison has revealed that the aa3-type cytochrome c oxidase and the bo3-type quinol oxidase are variations on the same theme: the heme-copper oxidase. A third member of this family has recently been recognized: the cbb3-type cytochrome c oxidase. Here we give an overview, and report that nitric oxide (NO) reductase, a bc-type cytochrome involved in denitrification, shares important features with these terminal oxidases as well. Tentative structural, functional and evolutionary implications are discussed.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalFEMS Microbiology Letters
Volume121
Issue number1
Publication statusPublished - 1 Aug 1994

Keywords

  • Amino Acid Sequence
  • Bacterial Proteins
  • Copper
  • Electron Transport Complex IV
  • Hemeproteins
  • Metalloproteins
  • Molecular Sequence Data
  • Oxidoreductases
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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