The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val(66)Met

B.M. Elzinga; M.L. Molendijk; R.C.O. Voshaar; B.A.A. Bus; J. Prickaerts; P. Spinhoven; B.W.J.H. Penninx

doi:10.1007/s00213-010-1961-1

The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val(66)Met

B.M. Elzinga, M.L. Molendijk, R.C.O. Voshaar, B.A.A. Bus, J. Prickaerts, P. Spinhoven, B.W.J.H. Penninx

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Abstract

Rationale: Recent findings show lowered brain-derived neurotrophic factor (BDNF) levels in major depressive disorder (MDD). Exposure to stressful life events may (partly) underlie these BDNF reductions, but little is known about the effects of early or recent life stress on BDNF levels. Moreover, the effects of stressful events on BDNF levels may in part be conditional upon a common variant on the BDNF gene (Val

Original language	English
Pages (from-to)	319-328
Journal	Psychopharmacology
Volume	214
Issue number	1
DOIs	https://doi.org/10.1007/s00213-010-1961-1
Publication status	Published - 2011

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AU - Voshaar, R.C.O.

AU - Bus, B.A.A.

AU - Prickaerts, J.

AU - Spinhoven, P.

AU - Penninx, B.W.J.H.

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The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val(66)Met

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