The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation

Renée Helmers; Dan M.J. Milstein; Nina F. Straat; Arash Navran; David N. Teguh; Robert A. van Hulst; Ludi E. Smeele; Jan de Lange

doi:10.1002/hed.27073

The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation

Renée Helmers^*, Dan M.J. Milstein, Nina F. Straat, Arash Navran, David N. Teguh, Robert A. van Hulst, Ludi E. Smeele, Jan de Lange

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Late side effects of radiotherapy in patients with head and neck cancer (HNCPs) result in decreased tissue vascularity, a compromised healing capacity and spontaneous breakdown of tissue. The aim of this study was to examine the in vivo effect of hyperbaric oxygen therapy (HBOT) on the microcirculation in irradiated oral tissue. Methods: Using a handheld microscope, the effect of HBOT on oral mucosal microcirculation parameters was measured in 34 previously irradiated HNCPs prior to HBOT and at 4 weeks and 6 months posttreatment. Results: A significant increase in mean buccal vessel density and decrease in buccal vessel diameter was found 6 months after HBOT compared to baseline, 22 ± 11 versus 25 ± 7 cpll/mm² (p < 0.05) and 20 ± 4 versus 16 ± 5 μm (p < 0.05), respectively. Conclusion: Our results indicate that oral microcirculation histopathology associated with irradiation is able to respond to HBOT by redirecting oral microcirculation parameters towards values consistent with healthy tissue.

Original language	English
Pages (from-to)	1646-1654
Number of pages	9
Journal	Head and Neck
Volume	44
Issue number	7
Early online date	29 Apr 2022
DOIs	https://doi.org/10.1002/hed.27073
Publication status	Published - Jul 2022

Bibliographical note

Funding Information:
We would like to thank all patients for participating in this investigation. Also, we greatly appreciate the broad support and cooperation regarding the staff of the Hyperbaric Medicine Department. This research was supported by a grant from Fonds NutsOHRA (No. 1303‐014).

Publisher Copyright:
© 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.

Funding

We would like to thank all patients for participating in this investigation. Also, we greatly appreciate the broad support and cooperation regarding the staff of the Hyperbaric Medicine Department. This research was supported by a grant from Fonds NutsOHRA (No. 1303‐014).

Keywords

head and neck cancer
hyperbaric oxygen therapy
incident dark-field imaging
late irradiation injury
microcirculation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.27073

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Cite this

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title = "The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation",

abstract = "Background: Late side effects of radiotherapy in patients with head and neck cancer (HNCPs) result in decreased tissue vascularity, a compromised healing capacity and spontaneous breakdown of tissue. The aim of this study was to examine the in vivo effect of hyperbaric oxygen therapy (HBOT) on the microcirculation in irradiated oral tissue. Methods: Using a handheld microscope, the effect of HBOT on oral mucosal microcirculation parameters was measured in 34 previously irradiated HNCPs prior to HBOT and at 4 weeks and 6 months posttreatment. Results: A significant increase in mean buccal vessel density and decrease in buccal vessel diameter was found 6 months after HBOT compared to baseline, 22 ± 11 versus 25 ± 7 cpll/mm2 (p < 0.05) and 20 ± 4 versus 16 ± 5 μm (p < 0.05), respectively. Conclusion: Our results indicate that oral microcirculation histopathology associated with irradiation is able to respond to HBOT by redirecting oral microcirculation parameters towards values consistent with healthy tissue.",

keywords = "head and neck cancer, hyperbaric oxygen therapy, incident dark-field imaging, late irradiation injury, microcirculation",

author = "Ren{\'e}e Helmers and Milstein, {Dan M.J.} and Straat, {Nina F.} and Arash Navran and Teguh, {David N.} and {van Hulst}, {Robert A.} and Smeele, {Ludi E.} and {de Lange}, Jan",

note = "Funding Information: We would like to thank all patients for participating in this investigation. Also, we greatly appreciate the broad support and cooperation regarding the staff of the Hyperbaric Medicine Department. This research was supported by a grant from Fonds NutsOHRA (No. 1303‐014). Publisher Copyright: {\textcopyright} 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.",

year = "2022",

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doi = "10.1002/hed.27073",

language = "English",

volume = "44",

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journal = "Head and Neck",

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AU - Helmers, Renée

AU - Milstein, Dan M.J.

AU - Straat, Nina F.

AU - Navran, Arash

AU - Teguh, David N.

AU - van Hulst, Robert A.

AU - Smeele, Ludi E.

AU - de Lange, Jan

N1 - Funding Information: We would like to thank all patients for participating in this investigation. Also, we greatly appreciate the broad support and cooperation regarding the staff of the Hyperbaric Medicine Department. This research was supported by a grant from Fonds NutsOHRA (No. 1303‐014). Publisher Copyright: © 2022 The Authors. Head & Neck published by Wiley Periodicals LLC.

PY - 2022/7

Y1 - 2022/7

N2 - Background: Late side effects of radiotherapy in patients with head and neck cancer (HNCPs) result in decreased tissue vascularity, a compromised healing capacity and spontaneous breakdown of tissue. The aim of this study was to examine the in vivo effect of hyperbaric oxygen therapy (HBOT) on the microcirculation in irradiated oral tissue. Methods: Using a handheld microscope, the effect of HBOT on oral mucosal microcirculation parameters was measured in 34 previously irradiated HNCPs prior to HBOT and at 4 weeks and 6 months posttreatment. Results: A significant increase in mean buccal vessel density and decrease in buccal vessel diameter was found 6 months after HBOT compared to baseline, 22 ± 11 versus 25 ± 7 cpll/mm2 (p < 0.05) and 20 ± 4 versus 16 ± 5 μm (p < 0.05), respectively. Conclusion: Our results indicate that oral microcirculation histopathology associated with irradiation is able to respond to HBOT by redirecting oral microcirculation parameters towards values consistent with healthy tissue.

AB - Background: Late side effects of radiotherapy in patients with head and neck cancer (HNCPs) result in decreased tissue vascularity, a compromised healing capacity and spontaneous breakdown of tissue. The aim of this study was to examine the in vivo effect of hyperbaric oxygen therapy (HBOT) on the microcirculation in irradiated oral tissue. Methods: Using a handheld microscope, the effect of HBOT on oral mucosal microcirculation parameters was measured in 34 previously irradiated HNCPs prior to HBOT and at 4 weeks and 6 months posttreatment. Results: A significant increase in mean buccal vessel density and decrease in buccal vessel diameter was found 6 months after HBOT compared to baseline, 22 ± 11 versus 25 ± 7 cpll/mm2 (p < 0.05) and 20 ± 4 versus 16 ± 5 μm (p < 0.05), respectively. Conclusion: Our results indicate that oral microcirculation histopathology associated with irradiation is able to respond to HBOT by redirecting oral microcirculation parameters towards values consistent with healthy tissue.

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KW - hyperbaric oxygen therapy

KW - incident dark-field imaging

KW - late irradiation injury

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The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculation

Abstract

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Keywords

UN SDGs

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