The Impact of Omega-3 Supplements on Non-Surgical Periodontal Therapy: A Systematic Review

Luísa Martins Miller, Flávia Benetti Piccinin, Ubele van der Velden, Sabrina Carvalho Gomes*

*Corresponding author for this work

Research output: Contribution to JournalReview articleAcademicpeer-review


Aim: This systematic review examined the additional effect of taking omega-3 supplements on periodontal therapy. Methods: The focused question was “What is the possible effect of omega-3 supplementation concomitant to non-surgical periodontal therapy on clinical periodontal parameters?” Databases Cochrane, Embase, Google Scholar, PubMed, and Web of Science (January-July 2021) were searched to identify appropriate studies. Randomized clinical trials (RCT) about non-surgical therapy with omega-3 supplementation, with at least 3 months of supplementation period were included. Cochrane risk of bias tool version 2 and Grading of Recommendations Assessment, Development, and Evaluation were used. Results: A total of 1556 studies were found, of which eight studies met the inclusion criteria. All eight studies evaluated periodontal probing depth and clinical attachment loss; plaque and gingival inflammation were evaluated in seven studies. High variety of omega-3 dosage, different study lengths, questionable results from periodontal therapy (including test and control groups), high risk of bias and moderate quality of evidence prevented a satisfactory conclusion regarding the benefits of omega-3 supplementation. The studies’ high heterogeneity avoided meta-analysis. Conclusion: Notwithstanding all limitations, the promising effects of omega-3 supplementation presented in two six-month studies encourage performing RCT with better-defined treatment protocols and greater methodological rigor.

Original languageEnglish
Article number1838
Pages (from-to)1-14
Number of pages14
Issue number9
Early online date28 Apr 2022
Publication statusPublished - 1 May 2022

Bibliographical note

Special Issue: Interrelationships between Nutrition and the Dental Profession.

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • fatty acids
  • omega 3
  • periodontal diseases
  • periodontitis


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