The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

T.W. Winkler, A.E. Justice, M. Graff, L. Barata, M.F. Feitosa, S. Chu, J. Czajkowski, T. Esko, T. Fall, T.O. Kilpelainen, Y. Lu, R. Magi, E. Mihailov, T.H. Pers, S. Rueeger, A. Teumer, G.B. Ehret, T. Ferreira, N.L. Heard-Costa, J. KarjalainenV. Lagou, A. Mahajan, M.D. Neinast, I. Prokopenko, J. Simino, T.M. Teslovich, R. Jansen, H. Westra, C.C. White, D. Absher, T.S. Ahluwalia, S. Ahmad, E. Albrecht, A.C. Alves, J.L. Bragg-Gresham, A.J.M. Craen, J.C. Bis, A. Bonnefond, G. Boucher, G. Cadby, Y. Cheng, C.W.K. Chiang, G. Delgado, A. Demirkan, N. Dueker, N. Eklund, G. Eiriksdottir, J. Eriksson, B. Feenstra, K. Fischer, F. Frau, T.E. Galesloot, F. Geller, A. Goel, M. Gorski, T.B. Grammer, S. Gustafsson, S. Haitjema, J.J. Hottenga, J.E. Huffman, A.U. Jackson, K.B. Jacobs, A. Johansson, M. Kaakinen, M.E. Kleber, J. Lahti, I.M. Leach, B. Lehne, K.S. Lo, M. Lorentzon, J. Luan, P.A.F. Madden, M. Mangino, B. McKnight, C. Medina-Gomez, K.L. Monda, M.E. Montasser, G. Mueller, M. 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Forouhi, N. Friedrich, P. V. Gejman, B. Gigante, N. Glorioso, A.S. Go, O. Gottesman, J. Graessler, H. Grallert, N. Grarup, Y. Gu, L. Broer, A.C. van der Ham, T. Hansen, T.B. Harris, C.A. Hartman, M. Hassinen, N. Hastie, A.T. Hattersley, A.C. Heath, A.K. Henders, D. Hernandez, H. Hillege, O. Holmen, K.G. Hovingh, J. Hui, L.L. Husemoen, N. Hutri-Kahonen, P.G. Hysi, T. Illig, P.L. de Jager, S. Jalilzadeh, T. Jorgensen, J.W. Jukema, M. Juonala, S. Kanoni, M. Karaleftheri, K.T. Khaw, L. Kinnunen, S.J. Kittner, W. Koenig, I. Kolcic, P. Kovacs, N.T. Krarup, W. Kratzer, J. Krueger, D Kuh, M. Kumari, T. Kyriakou, C. Langenberg, L. Lannfelt, C. Lanzani, V. Lotay, L.J. Launer, K. Leander, J. Lindstrom, A. Linneberg, Y. Liu, S. Lobbens, R. Luben, V. Lyssenko, S. Mannisto, P.K. Magnusson, W.L. McArdle, C. Menni, S. Merger, L. Milani, G.W. Montgomery, A.P. Morris, N. Narisu, M. Nelis, K.K. Ong, A. Palotie, L. Perusse, I. Pichler, M.G. Pilia, A. Pouta, M. Rheinberger, R. Ribel-Madsen, M. Richards, K.M. Rice, T.K. Rice, C. Rivolta, V. Salomaa, A.R. Sanders, M.A. Sarzynski, S. Scholtens, R.A. Scott, W.R. Scott, S. Sebert, S. Sengupta, B. Sennblad, T. Seufferlein, A. Silveira, P.E. Slagboom, J.H. Smit, T.H. Sparso, K. Stirrups, R.P Stolk, H.M. Stringham, M.A. Swertz, A.J. Swift, A. Syvanen, S. Tan, B. Thorand, A. Toenjes, A. Tremblay, E. Tsafantakis, P.J. van der Most, U. Voelker, M. Vohl, J.M. Vonk, M. Waldenberger, R.W. Walker, R. Wennauer, E. Widen, G. Willemsen, T. Wilsgaard, A.F. Wright, M.C. Zillikens, S.C. van Dijk, N.M. van Schoor, F.W. Asselbergs, P.I.W. Bakker, J.S. Beckmann, J. Beilby, D.A. Bennett, R.N. Bergman, S. Bergmann, C.A. Boeger, B.O. Boehm, E. Boerwinkle, D.I. Boomsma, S.R. Bornstein, E.P. Bottinger, C. Bouchard, J.C. Chambers, S.J. Chanock, D.I. Chasman, F. Cucca, D. Cusi, G. Dedoussis, J. Erdmann, J.G. Eriksson, D.A. Evans, U. de Faire, M. Farrall, L. Ferrucci, I. Ford, L. Franke, P.W. Franks, P. Froguel, R.T. Gansevoort, C. Gieger, H. Gronberg, V. Gudnason, U. Gyllensten, P. Hall, A. Hamsten, P. van der Harst, C. Hayward, M. Heliovaara, C. Hengstenberg, A.A. Hicks, A. Hingorani, A. Hofman, F. Hu, H.V. Huikuri, K. Hveem, A.L. James, J.M. Jordan, A. Jula, M. Kaehoenen, E. Kajantie, S. Kathiresan, L.A.L.M. Kiemeney, M. Kivimaki, P.B. Knekt, H.A. Koistinen, J.S. Kooner, S. Koskinen, J. Kuusisto, W. Maerz, N.G. Martin, M. Laakso, T.A. Lakka, T. Lehtimaki, G. Lettre, D. F. Levinson, L. Lind, M. Lokki, P. Mantyselka, M. Melbye, A. Metspalu, B.D. Mitchell, F.L. Moll, J.C. Murray, A.W. Musk, M.S. Nieminen, I. Njolstad, C. Ohlsson, A.J. Oldehinkel, B.A. Oostra, L.J. Palmer, J.S. Pankow, G. Pasterkamp, N.L. Pedersen, O. Pedersen, B.W.J.H. Penninx, M. Perola, A. Peters, O. Polasek, P.P. Pramstaller, B.M. Psaty, L. Qi, T. Quertermous, O.T. Raitakari, T. Rankinen, R. Rauramaa, P.M. Ridker, J.D. Rioux, F. Rivadeneira, J.I. Rotter, I. Rudan, H.M. den Ruijter, J. Saltevo, N. Sattar, H. Schunkert, P.E.H. Schwarz, A.R. Shuldiner, J. Sinisalo, H. Snieder, T.I.A. Sorensen, T.D. Spector, J.A. Staessen, B. Stefania, U. Thorsteinsdottir, M. Stumvoll, J. Tardif, E. Tremoli, J. Tuomilehto, A. G. Uitterlinden, M. Uusitupa, A.L.M. Verbeek, S.H. Vermeulen, J.S. Viikari, V. Vitart, H. Voelzke, P. Vollenweider, G. Waeber, M. Walker, H. Wallaschofski, N.J. Wareham, H. Watkins, E. Zeggini, A. Chakravarti, D.J. Clegg, L.A. Cupples, P. Gordon-Larsen, C.E. Jaquish, D.C. Rao, G.R. Abecasis, T.L. Assimes, I. Barroso, S.I. Berndt, M. Boehnke, P. Deloukas, C.S. Fox, L.C. Groop, D.J. Hunter, E. Ingelsson, R.C. Kaplan, M.I. McCarthy, K.L. Mohlke, J.R. O'Connell, D. Schlessinger, D.P. Strachan, K. Stefansson, C.M. van Duijn, J.N. Hirschhorn, C.M. Lindgren, I.M. Heid, K.E. North, I.B. Borecki, Z. Kutalik, R.J.F. Loos

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR
Original languageEnglish
Article numbere1005378
JournalPLoS Genetics
Volume11
Issue number10
DOIs
Publication statusPublished - 2015

Bibliographical note

PT: J; UT: WOS:000364401600002

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