The influence of nitric oxide on in vivo human skeletal properties

J.P. Folland, H. Maas, D.A. Jones

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    We have investigated the action of exogenous nitric oxide (NO) on the strength and contractile properties of human skeletal muscle working in vivo. Maximum isometric voluntary contraction force (MVC) of the quadriceps was measured and superimposed electrical stimulation was used to estimate the level of activation and 'true maximum force' (TMF). Force-frequency relationships were determined to assess changes in contractile properties of the muscle. Subjects in the experimental group (E, n = 10) were measured before and during two separate periods of treatment with different doses of glyceryl trinitrate, a NO donor, delivering 100 (GTN100) or 200 (GTN200) μg h
    Original languageEnglish
    Pages (from-to)141-148
    JournalActa Physiologica Scandinavica
    Publication statusPublished - 2000


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