The information gain from peak height data in DNA mixtures

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Abstract

We present the results of a comparison of likelihood ratios obtained from DNA mixture data, obtained either by a peak height model (EuroForMix) and by a discrete model, using probabilities of dropout and integrating over them (MixKin). We use the mixture data that have been published in [1] and were made publicly available. We show that, for mixtures for which replicate analyses were available in this set, there is almost no difference in weight of evidence, suggesting that the additional information in the peak heights is limited. On the other hand, for mixtures for which only a single replicate is available, the weight of evidence for true donors can be substantially higher with the peak height model, especially so for major donors and also for minor donors provided they are the only minor contributor to the mixture. False positive rates were very low with both methods, but for related non-contributors the risk of a false positive is much higher with the discrete method unless kinship is taken into account in the likelihood ratio calculation.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalForensic Science International: Genetics
Volume36
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • DNA mixtures
  • Weight of evidence

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