The involvement of astrocytes in early-life adversity induced programming of the brain

Maralinde R. Abbink, Anne Lieke F. van Deijk, Vivi M. Heine, Mark H. Verheijen, Aniko Korosi

Research output: Contribution to JournalReview articleAcademicpeer-review

Abstract

Early-life adversity (ELA) in the form of stress, inflammation, or malnutrition, can increase the risk of developing psychopathology or cognitive problems in adulthood. The neurobiological substrates underlying this process remain unclear. While neuronal dysfunction and microglial contribution have been studied in this context, only recently the role of astrocytes in early-life programming of the brain has been appreciated. Astrocytes serve many basic roles for brain functioning (e.g., synaptogenesis, glutamate recycling), and are unique in their capacity of sensing and integrating environmental signals, as they are the first cells to encounter signals from the blood, including hormonal changes (e.g., glucocorticoids), immune signals, and nutritional information. Integration of these signals is especially important during early development, and therefore we propose that astrocytes contribute to ELA induced changes in the brain by sensing and integrating environmental signals and by modulating neuronal development and function. Studies in rodents have already shown that ELA can impact astrocytes on the short and long term, however, a critical review of these results is currently lacking. Here, we will discuss the developmental trajectory of astrocytes, their ability to integrate stress, immune, and nutritional signals from the early environment, and we will review how different types of early adversity impact astrocytes.

Original languageEnglish
Pages (from-to)1637-1653
Number of pages17
JournalGlia
Volume67
Issue number9
Early online date30 Apr 2019
DOIs
Publication statusPublished - Sep 2019

Fingerprint

Astrocytes
Brain
Aptitude
Recycling
Psychopathology
Malnutrition
Glucocorticoids
Glutamic Acid
Rodentia
Inflammation

Keywords

  • early inflammation
  • early malnutrition
  • early stress
  • GFAP
  • maternal separation/deprivation

Cite this

Abbink, Maralinde R. ; van Deijk, Anne Lieke F. ; Heine, Vivi M. ; Verheijen, Mark H. ; Korosi, Aniko. / The involvement of astrocytes in early-life adversity induced programming of the brain. In: Glia. 2019 ; Vol. 67, No. 9. pp. 1637-1653.
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The involvement of astrocytes in early-life adversity induced programming of the brain. / Abbink, Maralinde R.; van Deijk, Anne Lieke F.; Heine, Vivi M.; Verheijen, Mark H.; Korosi, Aniko.

In: Glia, Vol. 67, No. 9, 09.2019, p. 1637-1653.

Research output: Contribution to JournalReview articleAcademicpeer-review

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