TY - JOUR
T1 - The link between obesity and the gut microbiota and immune system in early-life
AU - Magalhães, Maria Inês
AU - Azevedo, Maria João
AU - Castro, Flávia
AU - Oliveira, Maria José
AU - Costa, Ângela M.
AU - Sampaio Maia, Benedita
N1 - Publisher Copyright:
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2025
Y1 - 2025
N2 - In early-life, the gut microbiota is highly modifiable, being modulated by external factors such as maternal microbiota, mode of delivery, and feeding strategies. The composition of the child’s gut microbiota will deeply impact the development and maturation of its immune system, with consequences for future health. As one of the main sources of microorganisms to the child, the mother represents a crucial factor in the establishment of early-life microbiota, impacting the infant’s wellbeing. Recent studies have proposed that dysbiotic maternal gut microbiota could be transmitted to the offspring, influencing the development of its immunity, and leading to the development of diseases such as obesity. This paper aims to review recent findings in gut microbiota and immune system interaction in early-life, highlighting the benefits of a balanced gut microbiota in the regulation of the immune system.
AB - In early-life, the gut microbiota is highly modifiable, being modulated by external factors such as maternal microbiota, mode of delivery, and feeding strategies. The composition of the child’s gut microbiota will deeply impact the development and maturation of its immune system, with consequences for future health. As one of the main sources of microorganisms to the child, the mother represents a crucial factor in the establishment of early-life microbiota, impacting the infant’s wellbeing. Recent studies have proposed that dysbiotic maternal gut microbiota could be transmitted to the offspring, influencing the development of its immunity, and leading to the development of diseases such as obesity. This paper aims to review recent findings in gut microbiota and immune system interaction in early-life, highlighting the benefits of a balanced gut microbiota in the regulation of the immune system.
KW - dysbiosis
KW - early-life
KW - immunity
KW - Microbiota
KW - obesity
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U2 - 10.1080/1040841X.2024.2342427
DO - 10.1080/1040841X.2024.2342427
M3 - Review article
C2 - 38651972
AN - SCOPUS:85191097302
SN - 1040-841X
VL - 51
SP - 264
EP - 284
JO - Critical Reviews in Microbiology
JF - Critical Reviews in Microbiology
IS - 2
ER -