The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria

B.O. Fabriek, R. van Bruggen, D.M. Deng, A.J.M. Ligtenberg, K. Nazmi, K. Schornagel, R.P.M. Vloet, C.D. Dijkstra, T.K. van den Berg

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    The plasma membrane glycoprotein re- ceptor CD163 is a member of the scaven- ger receptor cystein-rich (SRCR) super- family class B that is highly expressed on resident tissue macrophages in vivo. Pre- viously, the molecule has been shown to act as a receptor for hemoglobin- haptoglobin complexes and to mediate cell-cell interactions between macro- phages and developing erythroblasts in erythroblastic islands. Here, we provide evidence for a potential role for CD163 in host defense. In particular, we demon- strate that CD163 can function as a macro- phage receptor for bacteria. CD163 was shown to bind both Gram-positive and -negative bacteria, and a previously iden- tified cell-binding motif in the second scavenger domain of CD163 was suffi- cient to mediate this binding. Expression of CD163 in monocytic cells promoted bacteria-induced proinflammatory cyto- kine production. Finally, newly generated antagonistic antibodies against CD163 were able to potently inhibit cytokine pro- duction elicited by bacteria in freshly isolated human monocytes. These find- ings identify CD163 as a macrophage receptor for bacteria and suggest that, during bacterial infection, CD163 on resi- dent tissue macrophages acts as an in- nate immune sensor and inducer of local inflammation. © 2009 by The American Society of Hematology.
    Original languageEnglish
    Pages (from-to)887-892
    JournalBlood
    Volume113
    Issue number4
    DOIs
    Publication statusPublished - 2009

    Bibliographical note

    J JAN 22

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