The Molecular Anatomy of Diffuse Gliomas in Adults

Floris Pieter Barthel

    Research output: PhD ThesisPhD-Thesis - Research and graduation internal

    225 Downloads (Pure)

    Abstract

    Diffuse gliomas encompass a diverse group of tumors of the central nervous system that primarily affect the brain. Patients suffer from a poor prognosis despite radical treatment with surgery, radio- and chemotherapy. Microscopic evaluation by a neuropathologist has been the established method for the clinical diagnosis and determination of follow-up for over a century. Nevertheless, pathology assessment suffers from sampling biases and interobserver variability. This thesis details a number of studies that focus on the molecular analysis of this tumor type. They are a part of a larger series of papers in the past decade that demonstrate that molecular diagnostics can provide an unambiguous diagnosis and determination of follow-up treatment.
    Original languageEnglish
    QualificationPhD
    Awarding Institution
    • Vrije Universiteit Amsterdam
    Supervisors/Advisors
    • Verhaak, Roel, Supervisor, -
    • Wesseling, P., Co-supervisor, -
    Award date15 Sept 2022
    Place of Publications.l.
    Publisher
    Print ISBNs9789464584448
    Publication statusPublished - 15 Sept 2022

    Keywords

    • diffuse glioma
    • genomics
    • neuropathology
    • classification
    • sequencing
    • DNA methylation
    • radiotherapy
    • telomere length
    • tumor evolution

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