The Molecular Genetic Architecture of Self-Employment

M.J.H.M. Loos, C.A. Rietveld, N. Eklund, P.D. Koellinger, F. Rivadeneira, G.R. Abecasis, G.A. Ankra-Badu, S.E. Baumeister, D.J. Benjamin, R. Biffar, S. Blankenberg, D.I. Boomsma, D. Cesarini, F. Cucca, E.J.C. de Geus, G. Dedoussis, P. Deloukas, M. Dimitriou, G. Eiriksdottir, J. ErikssonC. Gieger, V. Gudnason, B. Höhne, R. Holle, A. Isaacs, M.R. Järvelin, M. Johannesson, M. Kaakinen, M. Kähönen, S. Kanoni, M.A. Laaksonen, J. Lahti, L.J. Launer, T. Lehtimäki, M. Loitfelder, P.K.E. Magnusson, S. Naitza, B.A. Oostra, M. Perola, K. Petrovic, L. Quaye, O. Raitakari, S. Ripatti, P. Scheet, D. Schlessinger, C.O. Schmidt, H. Schmidt, R. Schmidt, A. Senft, A.V. Smith, T.D. Spector, I. Surakka, R. Svento, A. Terracciano, E. Tikkanen, C.M. van Duijn, J. Viikari, H. Völzke, H.E. Wichmann, P.S. Wild, S.M. Willems, G. Willemsen, F.J. van Rooij, P.J.F. Groenen, A.G. Uitterlinden, A. Hofman, A.R. Thurik

Research output: Contribution to JournalArticleAcademicpeer-review


Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable-entrepreneurship-that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment estimated in twin data (σ
Original languageEnglish
Article numbere60542
Pages (from-to)e60542
JournalPLoS ONE
Issue number4
Publication statusPublished - 2013

Cohort Studies

  • Netherlands Twin Register (NTR)


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