The Molecular Genetic Architecture of Self-Employment

M.J.H.M. Loos; C.A. Rietveld; N. Eklund; P.D. Koellinger; F. Rivadeneira; G.R. Abecasis; G.A. Ankra-Badu; S.E. Baumeister; D.J. Benjamin; R. Biffar; S. Blankenberg; D.I. Boomsma; D. Cesarini; F. Cucca; E.J.C. de Geus; G. Dedoussis; P. Deloukas; M. Dimitriou; G. Eiriksdottir; J. Eriksson; C. Gieger; V. Gudnason; B. Höhne; R. Holle; A. Isaacs; M.R. Järvelin; M. Johannesson; M. Kaakinen; M. Kähönen; S. Kanoni; M.A. Laaksonen; J. Lahti; L.J. Launer; T. Lehtimäki; M. Loitfelder; P.K.E. Magnusson; S. Naitza; B.A. Oostra; M. Perola; K. Petrovic; L. Quaye; O. Raitakari; S. Ripatti; P. Scheet; D. Schlessinger; C.O. Schmidt; H. Schmidt; R. Schmidt; A. Senft; A.V. Smith; T.D. Spector; I. Surakka; R. Svento; A. Terracciano; E. Tikkanen; C.M. van Duijn; J. Viikari; H. Völzke; H.E. Wichmann; P.S. Wild; S.M. Willems; G. Willemsen; F.J. van Rooij; P.J.F. Groenen; A.G. Uitterlinden; A. Hofman; A.R. Thurik

doi:10.1371/journal.pone.0060542

The Molecular Genetic Architecture of Self-Employment

M.J.H.M. Loos, C.A. Rietveld, N. Eklund, P.D. Koellinger, F. Rivadeneira, G.R. Abecasis, G.A. Ankra-Badu, S.E. Baumeister, D.J. Benjamin, R. Biffar, S. Blankenberg, D.I. Boomsma, D. Cesarini, F. Cucca, E.J.C. de Geus, G. Dedoussis, P. Deloukas, M. Dimitriou, G. Eiriksdottir, J. ErikssonC. Gieger, V. Gudnason, B. Höhne, R. Holle, A. Isaacs, M.R. Järvelin, M. Johannesson, M. Kaakinen, M. Kähönen, S. Kanoni, M.A. Laaksonen, J. Lahti, L.J. Launer, T. Lehtimäki, M. Loitfelder, P.K.E. Magnusson, S. Naitza, B.A. Oostra, M. Perola, K. Petrovic, L. Quaye, O. Raitakari, S. Ripatti, P. Scheet, D. Schlessinger, C.O. Schmidt, H. Schmidt, R. Schmidt, A. Senft, A.V. Smith, T.D. Spector, I. Surakka, R. Svento, A. Terracciano, E. Tikkanen, C.M. van Duijn, J. Viikari, H. Völzke, H.E. Wichmann, P.S. Wild, S.M. Willems, G. Willemsen, F.J. van Rooij, P.J.F. Groenen, A.G. Uitterlinden, A. Hofman, A.R. Thurik

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Abstract

Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable-entrepreneurship-that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment estimated in twin data (σ

Original language	English
Article number	e60542
Pages (from-to)	e60542
Journal	PLoS ONE
Volume	8
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0060542
Publication status	Published - 2013

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0060542

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Loos, M. J. H. M., Rietveld, C. A., Eklund, N., Koellinger, P. D., Rivadeneira, F., Abecasis, G. R., Ankra-Badu, G. A., Baumeister, S. E., Benjamin, D. J., Biffar, R., Blankenberg, S., Boomsma, D. I., Cesarini, D., Cucca, F., de Geus, E. J. C., Dedoussis, G., Deloukas, P., Dimitriou, M., Eiriksdottir, G., ... Thurik, A. R. (2013). The Molecular Genetic Architecture of Self-Employment. PLoS ONE, 8(4), e60542. Article e60542. https://doi.org/10.1371/journal.pone.0060542

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title = "The Molecular Genetic Architecture of Self-Employment",

abstract = "Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable-entrepreneurship-that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment estimated in twin data (σ",

author = "M.J.H.M. Loos and C.A. Rietveld and N. Eklund and P.D. Koellinger and F. Rivadeneira and G.R. Abecasis and G.A. Ankra-Badu and S.E. Baumeister and D.J. Benjamin and R. Biffar and S. Blankenberg and D.I. Boomsma and D. Cesarini and F. Cucca and {de Geus}, E.J.C. and G. Dedoussis and P. Deloukas and M. Dimitriou and G. Eiriksdottir and J. Eriksson and C. Gieger and V. Gudnason and B. H{\"o}hne and R. Holle and A. Isaacs and M.R. J{\"a}rvelin and M. Johannesson and M. Kaakinen and M. K{\"a}h{\"o}nen and S. Kanoni and M.A. Laaksonen and J. Lahti and L.J. Launer and T. Lehtim{\"a}ki and M. Loitfelder and P.K.E. Magnusson and S. Naitza and B.A. Oostra and M. Perola and K. Petrovic and L. Quaye and O. Raitakari and S. Ripatti and P. Scheet and D. Schlessinger and C.O. Schmidt and H. Schmidt and R. Schmidt and A. Senft and A.V. Smith and T.D. Spector and I. Surakka and R. Svento and A. Terracciano and E. Tikkanen and {van Duijn}, C.M. and J. Viikari and H. V{\"o}lzke and H.E. Wichmann and P.S. Wild and S.M. Willems and G. Willemsen and {van Rooij}, F.J. and P.J.F. Groenen and A.G. Uitterlinden and A. Hofman and A.R. Thurik",

year = "2013",

doi = "10.1371/journal.pone.0060542",

language = "English",

volume = "8",

pages = "e60542",

journal = "PLoS ONE",

issn = "1932-6203",

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Loos, MJHM, Rietveld, CA, Eklund, N, Koellinger, PD, Rivadeneira, F, Abecasis, GR, Ankra-Badu, GA, Baumeister, SE, Benjamin, DJ, Biffar, R, Blankenberg, S, Boomsma, DI, Cesarini, D, Cucca, F, de Geus, EJC, Dedoussis, G, Deloukas, P, Dimitriou, M, Eiriksdottir, G, Eriksson, J, Gieger, C, Gudnason, V, Höhne, B, Holle, R, Isaacs, A, Järvelin, MR, Johannesson, M, Kaakinen, M, Kähönen, M, Kanoni, S, Laaksonen, MA, Lahti, J, Launer, LJ, Lehtimäki, T, Loitfelder, M, Magnusson, PKE, Naitza, S, Oostra, BA, Perola, M, Petrovic, K, Quaye, L, Raitakari, O, Ripatti, S, Scheet, P, Schlessinger, D, Schmidt, CO, Schmidt, H, Schmidt, R, Senft, A, Smith, AV, Spector, TD, Surakka, I, Svento, R, Terracciano, A, Tikkanen, E, van Duijn, CM, Viikari, J, Völzke, H, Wichmann, HE, Wild, PS, Willems, SM, Willemsen, G, van Rooij, FJ, Groenen, PJF, Uitterlinden, AG, Hofman, A & Thurik, AR 2013, 'The Molecular Genetic Architecture of Self-Employment', PLoS ONE, vol. 8, no. 4, e60542, pp. e60542. https://doi.org/10.1371/journal.pone.0060542

TY - JOUR

T1 - The Molecular Genetic Architecture of Self-Employment

AU - Loos, M.J.H.M.

AU - Rietveld, C.A.

AU - Eklund, N.

AU - Koellinger, P.D.

AU - Rivadeneira, F.

AU - Abecasis, G.R.

AU - Ankra-Badu, G.A.

AU - Baumeister, S.E.

AU - Benjamin, D.J.

AU - Biffar, R.

AU - Blankenberg, S.

AU - Boomsma, D.I.

AU - Cesarini, D.

AU - Cucca, F.

AU - de Geus, E.J.C.

AU - Dedoussis, G.

AU - Deloukas, P.

AU - Dimitriou, M.

AU - Eiriksdottir, G.

AU - Eriksson, J.

AU - Gieger, C.

AU - Gudnason, V.

AU - Höhne, B.

AU - Holle, R.

AU - Isaacs, A.

AU - Järvelin, M.R.

AU - Johannesson, M.

AU - Kaakinen, M.

AU - Kähönen, M.

AU - Kanoni, S.

AU - Laaksonen, M.A.

AU - Lahti, J.

AU - Launer, L.J.

AU - Lehtimäki, T.

AU - Loitfelder, M.

AU - Magnusson, P.K.E.

AU - Naitza, S.

AU - Oostra, B.A.

AU - Perola, M.

AU - Petrovic, K.

AU - Quaye, L.

AU - Raitakari, O.

AU - Ripatti, S.

AU - Scheet, P.

AU - Schlessinger, D.

AU - Schmidt, C.O.

AU - Schmidt, H.

AU - Schmidt, R.

AU - Senft, A.

AU - Smith, A.V.

AU - Spector, T.D.

AU - Surakka, I.

AU - Svento, R.

AU - Terracciano, A.

AU - Tikkanen, E.

AU - van Duijn, C.M.

AU - Viikari, J.

AU - Völzke, H.

AU - Wichmann, H.E.

AU - Wild, P.S.

AU - Willems, S.M.

AU - Willemsen, G.

AU - van Rooij, F.J.

AU - Groenen, P.J.F.

AU - Uitterlinden, A.G.

AU - Hofman, A.

AU - Thurik, A.R.

PY - 2013

Y1 - 2013

N2 - Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable-entrepreneurship-that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment estimated in twin data (σ

AB - Economic variables such as income, education, and occupation are known to affect mortality and morbidity, such as cardiovascular disease, and have also been shown to be partly heritable. However, very little is known about which genes influence economic variables, although these genes may have both a direct and an indirect effect on health. We report results from the first large-scale collaboration that studies the molecular genetic architecture of an economic variable-entrepreneurship-that was operationalized using self-employment, a widely-available proxy. Our results suggest that common SNPs when considered jointly explain about half of the narrow-sense heritability of self-employment estimated in twin data (σ

U2 - 10.1371/journal.pone.0060542

DO - 10.1371/journal.pone.0060542

M3 - Article

SN - 1932-6203

VL - 8

SP - e60542

JO - PLoS ONE

JF - PLoS ONE

IS - 4

M1 - e60542

ER -

The Molecular Genetic Architecture of Self-Employment

Abstract

Cohort Studies

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

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