Abstract

The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.

Original languageEnglish
Pages (from-to)1-14
Number of pages14
JournalTwin research and human genetics : the official journal of the International Society for Twin Studies
DOIs
Publication statusE-pub ahead of print - 31 Oct 2019

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Netherlands
Research
Genetic Association Studies
Biocompatible Materials
Pedigree
Spouses
Causality
Siblings
Biomarkers
Parents
Maintenance
Databases
DNA

Cite this

@article{283a43379cb7439cb090595c6da6d2c9,
title = "The Netherlands Twin Register: Longitudinal Research Based on Twin and Twin-Family Designs",
abstract = "The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.",
author = "Lannie Ligthart and {van Beijsterveldt}, {Catharina E M} and Kevenaar, {Sofieke T} and {de Zeeuw}, Eveline and {van Bergen}, Elsje and Susanne Bruins and Ren{\'e} Pool and Quinta Helmer and {van Dongen}, Jenny and Jouke-Jan Hottenga and {Van't Ent}, Dennis and Dolan, {Conor V} and Davies, {Gareth E} and Ehli, {Erik A} and Meike Bartels and Gonneke Willemsen and {de Geus}, {Eco J C} and Boomsma, {Dorret I}",
year = "2019",
month = "10",
day = "31",
doi = "10.1017/thg.2019.93",
language = "English",
pages = "1--14",
journal = "Twin Research and Human Genetics",
issn = "1832-4274",
publisher = "Australian Academic Press",

}

TY - JOUR

T1 - The Netherlands Twin Register

T2 - Longitudinal Research Based on Twin and Twin-Family Designs

AU - Ligthart, Lannie

AU - van Beijsterveldt, Catharina E M

AU - Kevenaar, Sofieke T

AU - de Zeeuw, Eveline

AU - van Bergen, Elsje

AU - Bruins, Susanne

AU - Pool, René

AU - Helmer, Quinta

AU - van Dongen, Jenny

AU - Hottenga, Jouke-Jan

AU - Van't Ent, Dennis

AU - Dolan, Conor V

AU - Davies, Gareth E

AU - Ehli, Erik A

AU - Bartels, Meike

AU - Willemsen, Gonneke

AU - de Geus, Eco J C

AU - Boomsma, Dorret I

PY - 2019/10/31

Y1 - 2019/10/31

N2 - The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.

AB - The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.

U2 - 10.1017/thg.2019.93

DO - 10.1017/thg.2019.93

M3 - Article

SP - 1

EP - 14

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

SN - 1832-4274

ER -