Abstract
The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.
| Original language | English |
|---|---|
| Pages (from-to) | 1-14 |
| Number of pages | 14 |
| Journal | Twin research and human genetics : the official journal of the International Society for Twin Studies |
| DOIs | |
| Publication status | E-pub ahead of print - 31 Oct 2019 |
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The Netherlands Twin Register : Longitudinal Research Based on Twin and Twin-Family Designs. / Ligthart, Lannie; van Beijsterveldt, Catharina E M; Kevenaar, Sofieke T; de Zeeuw, Eveline; van Bergen, Elsje; Bruins, Susanne; Pool, René; Helmer, Quinta; van Dongen, Jenny; Hottenga, Jouke-Jan; Van't Ent, Dennis; Dolan, Conor V; Davies, Gareth E; Ehli, Erik A; Bartels, Meike; Willemsen, Gonneke; de Geus, Eco J C; Boomsma, Dorret I.
In: Twin research and human genetics : the official journal of the International Society for Twin Studies, 31.10.2019, p. 1-14.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - The Netherlands Twin Register
T2 - Longitudinal Research Based on Twin and Twin-Family Designs
AU - Ligthart, Lannie
AU - van Beijsterveldt, Catharina E M
AU - Kevenaar, Sofieke T
AU - de Zeeuw, Eveline
AU - van Bergen, Elsje
AU - Bruins, Susanne
AU - Pool, René
AU - Helmer, Quinta
AU - van Dongen, Jenny
AU - Hottenga, Jouke-Jan
AU - Van't Ent, Dennis
AU - Dolan, Conor V
AU - Davies, Gareth E
AU - Ehli, Erik A
AU - Bartels, Meike
AU - Willemsen, Gonneke
AU - de Geus, Eco J C
AU - Boomsma, Dorret I
PY - 2019/10/31
Y1 - 2019/10/31
N2 - The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.
AB - The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.
U2 - 10.1017/thg.2019.93
DO - 10.1017/thg.2019.93
M3 - Article
SP - 1
EP - 14
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
SN - 1832-4274
ER -