Abstract
The Netherlands Twin Register (NTR) is a national register in which twins, multiples and their parents, siblings, spouses and other family members participate. Here we describe the NTR resources that were created from more than 30 years of data collections; the development and maintenance of the newly developed database systems, and the possibilities these resources create for future research. Since the early 1980s, the NTR has enrolled around 120,000 twins and a roughly equal number of their relatives. The majority of twin families have participated in survey studies, and subsamples took part in biomaterial collection (e.g., DNA) and dedicated projects, for example, for neuropsychological, biomarker and behavioral traits. The recruitment into the NTR is all inclusive without any restrictions on enrollment. These resources - the longitudinal phenotyping, the extended pedigree structures and the multigeneration genotyping - allow for future twin-family research that will contribute to gene discovery, causality modeling, and studies of genetic and cultural inheritance.
Original language | English |
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Pages (from-to) | 623-636 |
Number of pages | 14 |
Journal | Twin research and human genetics : the official journal of the International Society for Twin Studies |
Volume | 22 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2019 |
Funding
The Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW) grants 904-61-090, 985-10-002, 912-10-020, 904-61-193,480-04-004, 463-06-001, 451-04-034, 400-05-717, Addiction-31160008, 016-115-035, 481-08-011, 056-32-010, Middelgroot-911-09-032, OCW-NWO Gravity program-024.001.003, NWO-Groot 480-15-001/674, NWO Veni 451-15-017, Center for Medical Systems Biology (CSMB, NWO Genomics), NBIC/BioAssist/RK(2008.024), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL, 184.021.007 and 184.033.111); Spinozapremie (NWO-56-464-14192), KNAW Academy Professor Award (PAH/6635) and University Research Fellow grant (URF) to DIB; Amsterdam Public Health research institute (former EMGO+), Neuroscience Amsterdam research institute (former NCA); the European Science Foundation (ESF, EU/QLRT-2001-01254), the European Community's Seventh Framework Program (FP7-HEALTH-F4-2007-2013, grant 01413: ENGAGE and grant 602768: ACTION); the European Research Council (ERC Starting 284167, ERC Consolidator 771057, ERC Advanced 230374), Rutgers University Cell and DNA Repository (NIMH U24 MH068457-06), the National Institutes of Health (NIH, R01D0042157-01A1, R01MH58799-03, MH081802, DA018673, R01 DK092127-04, Grand Opportunity grants 1RC2 MH089951 and 1RC2 MH089995); the Avera Institute for Human Genetics, Sioux Falls, South Dakota (USA). Part of the genotyping and analyses were funded by the Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health. Computing was supported by NWO through grant 2018/EW/00408559, BiG Grid, the Dutch e-Science Grid and SURFSARA. Funding was obtained from the Netherlands Organization for Scientific Research (NWO) and The Netherlands Organisation for Health Research and Development (ZonMW) grants 904-61-090, 985-10-002, 912-10-020, 904-61-193,480-04-004, 463-06-001, 451-04-034, 400-05-717, Addiction-31160008, 016-115-035, 481-08-011, 056-32-010, Middelgroot-911-09-032, OCW_NWO Gravity program-024.001.003, NWO-Groot 480-15-001/674, NWO Veni 451-15-017, Center for Medical Systems Biology (CSMB, NWO Genomics), NBIC/BioAssist/RK(2008.024), Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL, 184.021.007 and 184.033.111); Spinozapremie (NWO-56-464-14192), KNAW Academy Professor Award (PAH/6635) and University Research Fellow grant (URF) to DIB; Amsterdam Public Health research institute (former EMGO+), Neuroscience Amsterdam research institute (former NCA); the European Science Foundation (ESF, EU/QLRT-2001-01254), the European Community’s Seventh Framework Program (FP7-HEALTH-F4-2007-2013, grant 01413: ENGAGE and grant 602768: ACTION); the European Research Council (ERC Starting 284167, ERC Consolidator 771057, ERC Advanced 230374), Rutgers University Cell and DNA Repository (NIMH U24 MH068457-06), the National Institutes of Health (NIH, R01D0042157-01A1, R01MH58799-03, MH081802, DA018673, R01 DK092127-04, Grand Opportunity grants 1RC2 MH089951 and 1RC2 MH089995); the Avera Institute for Human Genetics, Sioux Falls, South Dakota (USA). Part of the genotyping and analyses were funded by the Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health. Computing was supported by NWO through grant 2018/EW/00408559, BiG Grid, the Dutch e-Science Grid and SURFSARA.
Funders | Funder number |
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Amsterdam Public Health Research Institute | |
Avera Institute for Human Genetics | 2018/EW/00408559 |
BBMRI-NL | 184.033.111, 184.021.007, NWO-56-464-14192 |
Biobanking and Biomolecular Resources Research Infrastructure | |
CSMB | |
Center for Medical Systems Biology | |
ENGAGE | 602768 |
ERC | |
ESF | EU/QLRT-2001-01254 |
European Community's Seventh Framework Program | |
European Community’s Seventh Framework Program | |
European Research Council | |
European Science Foundation | |
FP7-HEALTH-F4-2007-2013 | 01413 |
KNAW | |
NBIC/BioAssist/RK | 2008.024 |
NIH | |
NIMH | |
NWO-Groot | 480-15-001/674, 451-15-017 |
National Institutes of Health | |
Netherlands Organisation for Health Research and Development | |
Netherlands Organization for Scientific Research | |
Neuroscience Amsterdam research institute | |
SURFsara | |
ZonMw | 016-115-035, 463-06-001, 481-08-011, 904-61-090, 904-61-193,480-04-004, 400-05-717, 451-04-034, 056-32-010, 985-10-002, 912-10-020 |
National Institutes of Health | 1RC2 MH089951, 1RC2 MH089995, R01 DK092127-04, DA018673, MH081802, R01D0042157-01A1, R01MH58799-03 |
National Institute of Mental Health | U24 MH068457-06 |
Horizon 2020 Framework Programme | 771057 |
European Research Council | 230374, 284167 |
European Science Foundation | |
Koninklijke Nederlandse Akademie van Wetenschappen | PAH/6635 |
ZonMw |
Cohort Studies
- Netherlands Twin Register (NTR)