The OBELIX project: early life exposure to endocrine disruptors and obesity

J. Legler, T.H.M. Hamers, M. van de Bor, G. Schoeters, L. van der Ven, M. Eggesbo, J. Koppe, T. Trnovec

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The hypothesis of whether early life exposure (both pre- and early postnatal) to endocrine-disrupting chemicals (EDCs) may be a risk factor for obesity and related metabolic diseases later in life will be tested in the European research project OBELIX (OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life). OBELIX is a 4-y project that started in May 2009 and which has the following 5 main objectives: 1) to assess early life exposure in humans to major classes of EDCs identified as potential inducers of obesity (ie, dioxin-like compounds, non-dioxin-like polychlorinated biphenyls, organochlorine pesticides, brominated flame retardants, phthalates, and perfluorinated compounds) by using mother-child cohorts from 4 European regions with different food-contaminant exposure patterns; 2) to relate early life exposure to EDCs with clinical markers, novel biomarkers, and health-effect data related to obesity; 3) to perform hazard characterization of early life exposure to EDCs for the development of obesity later in life by using a mouse model; 4) to determine mechanisms of action of obesogenic EDCs on developmental programming with in vivo and in vitro genomics and epigenetic analyses; and 5) to perform risk assessments of prenatal exposure to obesogenic EDCs in food by integrating maternal exposure through food-contaminant exposure and health-effect data in children and hazard data in animal studies. © 2011 American Society for Nutrition.
Original languageEnglish
Pages (from-to)1933S-1938S
JournalThe American Journal of Clinical Nutrition
Volume94
Issue number6 Suppl.
DOIs
Publication statusPublished - 2011

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