Abstract
A novel papain inhibitory protein (SPI) from Streptomyces mobaraensis was studied to measure its inhibitory effect on bacterial cysteine protease activity (Staphylococcus aureus SspB) and culture supernatants (Porphyromonas gingivalis, Bacillus anthracis). Further, growth of Bacillus anthracis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio cholerae was completely inhibited by 10 μM SPI. At this concentration of SPI, no cytotoxicity was observed. We conclude that SPI inhibits bacterial virulence factors and has the potential to become a novel therapeutic treatment against a range of unrelated pathogenic bacteria.
| Original language | English |
|---|---|
| Pages (from-to) | 3388-91 |
| Number of pages | 4 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 57 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2013 |
Keywords
- Bacillus anthracis/drug effects
- Bacterial Proteins/metabolism
- Cysteine Proteases/metabolism
- Cysteine Proteinase Inhibitors/pharmacology
- Papain/antagonists & inhibitors
- Porphyromonas gingivalis/drug effects
- Pseudomonas aeruginosa/drug effects
- Staphylococcus aureus/drug effects
- Streptomyces/chemistry
- Vibrio cholerae/drug effects
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