The pathogenesis of mucositis: updated perspectives and emerging targets

J. Bowen; N. Al-Dasooqi; P. Bossi; H. Wardill; Y. Van Sebille; A. Al-Azri; E. Bateman; M.E. Correa; J. Raber-Durlacher; A. Kandwal; B. Mayo; R.G. Nair; A. Stringer; K. ten Bohmer; D. Thorpe; R.V. Lalla; S. Sonis; K. Cheng; S. Elad

doi:10.1007/s00520-019-04893-z

The pathogenesis of mucositis: updated perspectives and emerging targets

J. Bowen, N. Al-Dasooqi, P. Bossi, H. Wardill, Y. Van Sebille, A. Al-Azri, E. Bateman, M.E. Correa, J. Raber-Durlacher, A. Kandwal, B. Mayo, R.G. Nair, A. Stringer, K. ten Bohmer, D. Thorpe, R.V. Lalla, S. Sonis, K. Cheng, S. Elad

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Mucositis research and treatment are a rapidly evolving field providing constant new avenues of research and potential therapies. The MASCC/ISOO Mucositis Study Group regularly assesses available literature relating to pathogenesis, mechanisms, and novel therapeutic approaches and distils this to summary perspectives and recommendations. Reviewers assessed 164 articles published between January 2011 and June 2016 to identify progress made since the last review and highlight new targets for further investigation. Findings were organized into sections including established and emerging mediators of toxicity, potential insights from technological advances in mucositis research, and perspective. Research momentum is accelerating for mucositis pathogenesis, and with this has come utilization of new models and interventions that target specific mechanisms of injury. Technological advances have the potential to revolutionize the field of mucositis research, although focused effort is needed to move rationally targeted interventions to the clinical setting

Original language	English
Pages (from-to)	4023-4033
Journal	Supportive Care in Cancer
Volume	27
Issue number	10
DOIs	https://doi.org/10.1007/s00520-019-04893-z
Publication status	Published - Oct 2019

Bibliographical note

Cited By :1

Export Date: 17 October 2019

Funding

We would like to acknowledge the expert assistance of our research librarians during the development of the database search terms and paper retrieval; Lorraine Porcello (Bibby Dental Library, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA) and Daniel A. Castillo (Edward G. Miner Library, University of Rochester Medical Center, Rochester, NY, USA). Additionally, we would like to thank Vinisha Ranna, DDS, and Anusha Vaddi, BDS, for their assistance with retrieving the papers.

Funders	Funder number
Vinisha Ranna
Medical Center, University of Rochester
Diabetes-Stiftung

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Bowen, J., Al-Dasooqi, N., Bossi, P., Wardill, H., Van Sebille, Y., Al-Azri, A., Bateman, E., Correa, M. E., Raber-Durlacher, J., Kandwal, A., Mayo, B., Nair, R. G., Stringer, A., ten Bohmer, K., Thorpe, D., Lalla, R. V., Sonis, S., Cheng, K., & Elad, S. (2019). The pathogenesis of mucositis: updated perspectives and emerging targets. Supportive Care in Cancer, 27(10), 4023-4033. https://doi.org/10.1007/s00520-019-04893-z

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abstract = "Mucositis research and treatment are a rapidly evolving field providing constant new avenues of research and potential therapies. The MASCC/ISOO Mucositis Study Group regularly assesses available literature relating to pathogenesis, mechanisms, and novel therapeutic approaches and distils this to summary perspectives and recommendations. Reviewers assessed 164 articles published between January 2011 and June 2016 to identify progress made since the last review and highlight new targets for further investigation. Findings were organized into sections including established and emerging mediators of toxicity, potential insights from technological advances in mucositis research, and perspective. Research momentum is accelerating for mucositis pathogenesis, and with this has come utilization of new models and interventions that target specific mechanisms of injury. Technological advances have the potential to revolutionize the field of mucositis research, although focused effort is needed to move rationally targeted interventions to the clinical setting",

author = "J. Bowen and N. Al-Dasooqi and P. Bossi and H. Wardill and {Van Sebille}, Y. and A. Al-Azri and E. Bateman and M.E. Correa and J. Raber-Durlacher and A. Kandwal and B. Mayo and R.G. Nair and A. Stringer and {ten Bohmer}, K. and D. Thorpe and R.V. Lalla and S. Sonis and K. Cheng and S. Elad",

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Bowen, J, Al-Dasooqi, N, Bossi, P, Wardill, H, Van Sebille, Y, Al-Azri, A, Bateman, E, Correa, ME, Raber-Durlacher, J, Kandwal, A, Mayo, B, Nair, RG, Stringer, A, ten Bohmer, K, Thorpe, D, Lalla, RV, Sonis, S, Cheng, K & Elad, S 2019, 'The pathogenesis of mucositis: updated perspectives and emerging targets', Supportive Care in Cancer, vol. 27, no. 10, pp. 4023-4033. https://doi.org/10.1007/s00520-019-04893-z

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AU - Bowen, J.

AU - Al-Dasooqi, N.

AU - Bossi, P.

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AU - Van Sebille, Y.

AU - Al-Azri, A.

AU - Bateman, E.

AU - Correa, M.E.

AU - Raber-Durlacher, J.

AU - Kandwal, A.

AU - Mayo, B.

AU - Nair, R.G.

AU - Stringer, A.

AU - ten Bohmer, K.

AU - Thorpe, D.

AU - Lalla, R.V.

AU - Sonis, S.

AU - Cheng, K.

AU - Elad, S.

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PY - 2019/10

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ER -

The pathogenesis of mucositis: updated perspectives and emerging targets

Abstract

Bibliographical note

Funding

UN SDGs

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