The physical, mental, and social impact of COPD in a population-based sample: results from the Longitudinal Aging Study Amsterdam

Frits M.E. Franssen*, Dionne E. Smid, Dorly J.H. Deeg, Martijn Huisman, Jan Poppelaars, Emiel F.M. Wouters, Martijn A. Spruit

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


Chronic obstructive pulmonary disease (COPD) is associated with substantial health impact that may already become apparent in early disease. This study aims to examine the features of subjects with COPD in a Dutch population-based sample and compare their physical status, mental status, and social status to non-COPD subjects. This study made use of Longitudinal Aging Study Amsterdam (LASA) data. Demographics, clinical characteristics, self-reported diseases, post-bronchodilator spirometry, physical, mental, and social status were assessed. A number of 810 subjects (50.5% male, mean age 60.5 ± 2.9 years) were included. Subjects with COPD (n = 68, mean FEV1 67.6 [IQR 60.4–80.4] %.) had a slower walking speed than non-COPD subjects, p = 0.033. When compared to non-COPD subjects, COPD subjects gave a lower rating on their health (physical subscale of SF-12: 15 [IQR 16.0–19.0] vs. 18 [IQR 11.0–17.0] points) and life (EQ5D VAS: 75 [IQR 70.0–90.0] vs. 80 points [IQR 65.0–85.5]) surveys. COPD subjects also had a more impaired disease-specific health status (CAT: 9.5 ± 5.9 vs. 6.7 ± 5.2, respectively), were less likely to have a partner (69% vs. 84%, respectively) and received emotional support less often (24% vs. 36%, respectively) compared to non-COPD subjects (All comparisons p < 0.001). In a population-based sample, subjects with COPD had a reduced physical performance, a more impaired disease-specific health status and were more socially deprived compared to non-COPD subjects. These impairments need to be taken into consideration when setting up a management program for patients with mild COPD.

Original languageEnglish
Article number30
Pages (from-to)1-6
Number of pages6
Journalnpj Primary Care Respiratory Medicine
Publication statusPublished - 10 Aug 2018


We are grateful to the all the subjects who were willing to participate in the current study. The authors would like to thank M. Akkermans and J. Oosterbaan for helping with collecting and converting the spirometry data. We thank S. Keene for English language editing. The Longitudinal Aging Study Amsterdam was financially supported by the Ministry of Health, Welfare and Sports (to the VU University; The Longitudinal Aging Study Amsterdam). D.E.S. was financially supported by GlaxoSmithKline (SCO115406).

FundersFunder number
Ministry of Health, Welfare and Sports
Vrije Universiteit Amsterdam
Ministerie van Volksgezondheid, Welzijn en SportLASA study


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