The proteomic landscape of synaptic diversity across brain regions and cell types

Funding

We thank the MPIBR Imaging Facility and the MPIBR Proteomics Facility for assistance with data acquisition. We thank the MPIBR Animal Facility and Guido Schmalbach and Fabian Bayer from the MPIBR workshop. We are grateful to the members of the Schuman lab. We thank Ina Bartnik, Teresa Spano, Christina Thum, and Belquis Nassim Assir for technical support; Etienne Herzog lab for sharing resources; and Julia Kuhl for graphical support. Funding: the Swiss National Science Foundation (SNSF) (P2EZP3_191820 and P400PB_199288), the Novartis Foundation for medical-biological research (22B079), and the Max Planck Society and the European Union (ERC, DiverseSynapse, 101054512). M.v.O. co-wrote the manuscript and performed all experiments except those noted below. T.M.B. performed immunoblotting, histology, and EM. S.L.G. performed proteasome experiments and immunoblotting. S.t.D. performed subfield dissections and contributed to methodology. G.T. contributed data analysis and developed https://syndive.org/. N.F. prepared synaptosomes. J.D.L. supervised proteomics. E.M.S. supervised the project and co-wrote the manuscript. The authors declare no competing interests. We thank the MPIBR Imaging Facility and the MPIBR Proteomics Facility for assistance with data acquisition. We thank the MPIBR Animal Facility and Guido Schmalbach and Fabian Bayer from the MPIBR workshop. We are grateful to the members of the Schuman lab. We thank Ina Bartnik, Teresa Spano, Christina Thum, and Belquis Nassim Assir for technical support; Etienne Herzog lab for sharing resources; and Julia Kuhl for graphical support. Funding: the Swiss National Science Foundation (SNSF) ( P2EZP3_191820 and P400PB_199288 ), the Novartis Foundation for medical-biological research ( 22B079 ), and the Max Planck Society and the European Union (ERC, DiverseSynapse, 101054512 ).