The PTH-FGF23-Vitamin D axis: New insights regarding oxidation and metabolism

Stan Rutger Ursem

The PTH-FGF23-Vitamin D axis: New insights regarding oxidation and metabolism

Stan Rutger Ursem

Research output: PhD Thesis › PhD-Thesis - Research and graduation internal

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Abstract

In this thesis, we researched several aspects of the hormones PTH (parathyroid hormone), FGF23 (fibroblast growth factor 23) and vitamin D. We studied the possibilities and limitations of a new method measuring only non-oxidized (bio-active) PTH in different (clinical) studies. In addition, we studied the relation between the bone-derived FGF23 and glucose metabolism. Lastly, we investigated in randomized controlled trials what the effect of vitamin D supplementation is on its metabolism.

Original language	English
Qualification	PhD
Awarding Institution	Vrije Universiteit Amsterdam
Supervisors/Advisors	Heijboer, A.C., Supervisor, - Lafleur, M.V.M., Supervisor, -
Award date	26 May 2021
Place of Publication	Amsterdam
Publisher	Off Page
Print ISBNs	9789493197558
Publication status	Published - 26 May 2021

Keywords

PTH
Parathyroid hormone
FGF23
fibroblast growth factor 23
non-oxidized PTH
n-oxPTH
Vitamin D

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The PTH-FGF23-Vitamin D axisFinal published version, 6.69 MB
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The PTH-FGF23-Vitamin D axis - thesis_redactedFinal published version, 11.8 MB

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abstract = "In this thesis, we researched several aspects of the hormones PTH (parathyroid hormone), FGF23 (fibroblast growth factor 23) and vitamin D. We studied the possibilities and limitations of a new method measuring only non-oxidized (bio-active) PTH in different (clinical) studies. In addition, we studied the relation between the bone-derived FGF23 and glucose metabolism. Lastly, we investigated in randomized controlled trials what the effect of vitamin D supplementation is on its metabolism.",

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N2 - In this thesis, we researched several aspects of the hormones PTH (parathyroid hormone), FGF23 (fibroblast growth factor 23) and vitamin D. We studied the possibilities and limitations of a new method measuring only non-oxidized (bio-active) PTH in different (clinical) studies. In addition, we studied the relation between the bone-derived FGF23 and glucose metabolism. Lastly, we investigated in randomized controlled trials what the effect of vitamin D supplementation is on its metabolism.

AB - In this thesis, we researched several aspects of the hormones PTH (parathyroid hormone), FGF23 (fibroblast growth factor 23) and vitamin D. We studied the possibilities and limitations of a new method measuring only non-oxidized (bio-active) PTH in different (clinical) studies. In addition, we studied the relation between the bone-derived FGF23 and glucose metabolism. Lastly, we investigated in randomized controlled trials what the effect of vitamin D supplementation is on its metabolism.

KW - PTH

KW - Parathyroid hormone

KW - FGF23

KW - fibroblast growth factor 23

KW - non-oxidized PTH

KW - n-oxPTH

KW - Vitamin D

M3 - PhD-Thesis - Research and graduation internal

SN - 9789493197558

PB - Off Page

CY - Amsterdam

ER -

The PTH-FGF23-Vitamin D axis: New insights regarding oxidation and metabolism

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