The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators

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Neurons secrete neuromodulators/neuropeptides from dense-core vesicles (DCVs) by a largely unknown mechanism. Persoon et al. identify RAB3 and RIM1/2 as essential factors. RAB3’s indispensable role is the first distinct feature of DCV secretion as compared to synaptic vesicle secretion.

Original languageEnglish
Pages (from-to)1065-1080.e12
Number of pages29
Issue number6
Early online date31 Oct 2019
Publication statusPublished - 18 Dec 2019


  • BDNF
  • dense-core vesicles
  • MUNC13
  • neuromodulators
  • neuropeptide
  • NPY
  • RAB3
  • RIM1/2
  • SEC4
  • secretion

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