The relation between frontal EEG asymmetry and the risk for anxiety and depression.

D.J.A. Smit; D. Posthuma; D.I. Boomsma; E.J.C. de Geus

doi:10.1016/j.biopsycho.2006.06.002

The relation between frontal EEG asymmetry and the risk for anxiety and depression.

D.J.A. Smit, D. Posthuma, D.I. Boomsma, E.J.C. de Geus

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Frontal asymmetry of EEG alpha power (FA) may index the risk for anxiety and depression. Evidence linking FA to the underlying biological mechanisms is scarce. This is unfortunate because FA has potential as a biological marker to support gene finding in anxiety and depression. We examined the heritability of FA in 732 twins and their singleton siblings, and established the genetic and environmental contribution to the relation between FA and the risk for anxiety and depression. Multivariate models showed that FA is heritable only in young adults (males 32% and females 37%) but not in middle-aged adults. A significant relation between FA and the risk for anxiety and depression was only found in young adult females. This relation was explained by shared genes influencing both EEG and disease risk. Future studies on asymmetry of left and right frontal brain activation should carefully consider the effects of sex and age. © 2006 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	26-33
Journal	Biological Psychology
Volume	74
Issue number	1
DOIs	https://doi.org/10.1016/j.biopsycho.2006.06.002
Publication status	Published - 2007

Cohort Studies

Netherlands Twin Register (NTR)

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title = "The relation between frontal EEG asymmetry and the risk for anxiety and depression.",

abstract = "Frontal asymmetry of EEG alpha power (FA) may index the risk for anxiety and depression. Evidence linking FA to the underlying biological mechanisms is scarce. This is unfortunate because FA has potential as a biological marker to support gene finding in anxiety and depression. We examined the heritability of FA in 732 twins and their singleton siblings, and established the genetic and environmental contribution to the relation between FA and the risk for anxiety and depression. Multivariate models showed that FA is heritable only in young adults (males 32% and females 37%) but not in middle-aged adults. A significant relation between FA and the risk for anxiety and depression was only found in young adult females. This relation was explained by shared genes influencing both EEG and disease risk. Future studies on asymmetry of left and right frontal brain activation should carefully consider the effects of sex and age. {\textcopyright} 2006 Elsevier B.V. All rights reserved.",

author = "D.J.A. Smit and D. Posthuma and D.I. Boomsma and {de Geus}, E.J.C.",

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T1 - The relation between frontal EEG asymmetry and the risk for anxiety and depression.

AU - Smit, D.J.A.

AU - Posthuma, D.

AU - Boomsma, D.I.

AU - de Geus, E.J.C.

PY - 2007

Y1 - 2007

N2 - Frontal asymmetry of EEG alpha power (FA) may index the risk for anxiety and depression. Evidence linking FA to the underlying biological mechanisms is scarce. This is unfortunate because FA has potential as a biological marker to support gene finding in anxiety and depression. We examined the heritability of FA in 732 twins and their singleton siblings, and established the genetic and environmental contribution to the relation between FA and the risk for anxiety and depression. Multivariate models showed that FA is heritable only in young adults (males 32% and females 37%) but not in middle-aged adults. A significant relation between FA and the risk for anxiety and depression was only found in young adult females. This relation was explained by shared genes influencing both EEG and disease risk. Future studies on asymmetry of left and right frontal brain activation should carefully consider the effects of sex and age. © 2006 Elsevier B.V. All rights reserved.

AB - Frontal asymmetry of EEG alpha power (FA) may index the risk for anxiety and depression. Evidence linking FA to the underlying biological mechanisms is scarce. This is unfortunate because FA has potential as a biological marker to support gene finding in anxiety and depression. We examined the heritability of FA in 732 twins and their singleton siblings, and established the genetic and environmental contribution to the relation between FA and the risk for anxiety and depression. Multivariate models showed that FA is heritable only in young adults (males 32% and females 37%) but not in middle-aged adults. A significant relation between FA and the risk for anxiety and depression was only found in young adult females. This relation was explained by shared genes influencing both EEG and disease risk. Future studies on asymmetry of left and right frontal brain activation should carefully consider the effects of sex and age. © 2006 Elsevier B.V. All rights reserved.

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DO - 10.1016/j.biopsycho.2006.06.002

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JO - Biological Psychology

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The relation between frontal EEG asymmetry and the risk for anxiety and depression.

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