The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort

Angela van der Putten-Toorenburg; Elke Butterbrod; Benjamin D. Schalet; Pieter J. van der Veere; Mukrabe E. Tewolde; Merel C. Postema; Elsmarieke Van De Giessen; Charlotte Teunissen; Argonde  van Harten; Wiesje van der Flier; SAM Sikkes

doi:10.1002/dad2.70233

The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort

Angela van der Putten-Toorenburg^*, Elke Butterbrod, Benjamin D. Schalet, Pieter J. van der Veere, Mukrabe E. Tewolde, Merel C. Postema, Elsmarieke Van De Giessen, Charlotte Teunissen, Argonde van Harten , Wiesje van der Flier, SAM Sikkes

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

INTRODUCTION
We explored the relationship between cognitive screening outcomes and everyday functioning in Alzheimer's disease (AD).

METHODS
A total of 1228 amyloid-positive participants were included from the Amsterdam Dementia Cohort. Multiple linear regression analyses assessed the relationship between Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and everyday functioning (Amsterdam Instrumental Activities of Daily Living Questionnaire [A-IADL-Q-30]). To link cognitive screeners to functional impairment, we described difficulties across A-IADL-Q-30 items by MMSE and MoCA quartiles.

RESULTS
Both MMSE (B = 0.96, 95% confidence interval [CI]0.87–1.04) and MoCA (B = 0.79, 95% CI 0.68–0.89) were associated with A-IADL-Q-30. In the lowest MMSE (0–20) and MoCA (0–16) quartiles, filling in forms (both 96%) and managing the household budget (95%–93%) were mostly affected, whereas working (74%) and using a computer (52%–50%) were primarily affected in the highest quartiles (MMSE 28–30/MoCA 25–30).

DISCUSSION
In amyloid-positive participants, the association between cognition and daily functioning was moderate, reinforcing the importance of assessing both constructs in disease monitoring.

Original language	English
Article number	e70233
Pages (from-to)	1-11
Number of pages	11
Journal	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume	18
Issue number	1
Early online date	4 Jan 2026
DOIs	https://doi.org/10.1002/dad2.70233
Publication status	E-pub ahead of print - 4 Jan 2026

Funding

The development of the Amsterdam IADL questionnaire is supported by grants from Stichting VUMC fonds and Innovatiefonds Zorgverzekeraars. Research of Alzheimer Center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting Steun Alzheimercentrum Amsterdam. The chair of W.F. is supported by the Pasman stichting. The present study is supported by a grant from TAP‐dementia, a ZonMw‐funded project (#10510032120003), in the context of the Dutch National Dementia Strategy. The authors gratefully acknowledge the participants for their contribution. The Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q-30) is free for use in all public health and not-for-profit organizations and can be requested at https://www.alzheimercentrum.nl/professionals/amsterdam-iadl. The development of the Amsterdam IADL questionnaire is supported by grants from Stichting VUMC fonds and Innovatiefonds Zorgverzekeraars. Research of Alzheimer Center Amsterdam is part of the neurodegeneration research program of Amsterdam Neuroscience. Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting Steun Alzheimercentrum Amsterdam. The chair of W.F. is supported by the Pasman stichting. The present study is supported by a grant from TAP-dementia, a ZonMw-funded project (#10510032120003), in the context of the Dutch National Dementia Strategy.

Funders	Funder number
Alzheimer Nederland
Dutch National Dementia Strategy
TAP-dementia
Stichting Steun Alzheimercentrum Amsterdam	10510032120003

Access to Document

10.1002/dad2.70233

Persistent URL (handle)

Persistent link

Cite this

van der Putten-Toorenburg, A., Butterbrod, E., Schalet, B. D., van der Veere, P. J., Tewolde, M. E., Postema, M. C., Van De Giessen, E., Teunissen, C., van Harten , A., van der Flier, W., & Sikkes, SAM. (2026). The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 18(1), 1-11. Article e70233. Advance online publication. https://doi.org/10.1002/dad2.70233

@article{8f92f476b4e043828fd0b290b0228b79,

title = "The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort",

abstract = "INTRODUCTION We explored the relationship between cognitive screening outcomes and everyday functioning in Alzheimer's disease (AD). METHODS A total of 1228 amyloid-positive participants were included from the Amsterdam Dementia Cohort. Multiple linear regression analyses assessed the relationship between Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and everyday functioning (Amsterdam Instrumental Activities of Daily Living Questionnaire [A-IADL-Q-30]). To link cognitive screeners to functional impairment, we described difficulties across A-IADL-Q-30 items by MMSE and MoCA quartiles. RESULTS Both MMSE (B = 0.96, 95\% confidence interval [CI]0.87–1.04) and MoCA (B = 0.79, 95\% CI 0.68–0.89) were associated with A-IADL-Q-30. In the lowest MMSE (0–20) and MoCA (0–16) quartiles, filling in forms (both 96\%) and managing the household budget (95\%–93\%) were mostly affected, whereas working (74\%) and using a computer (52\%–50\%) were primarily affected in the highest quartiles (MMSE 28–30/MoCA 25–30). DISCUSSION In amyloid-positive participants, the association between cognition and daily functioning was moderate, reinforcing the importance of assessing both constructs in disease monitoring.",

author = "\{van der Putten-Toorenburg\}, Angela and Elke Butterbrod and Schalet, \{Benjamin D.\} and \{van der Veere\}, \{Pieter J.\} and Tewolde, \{Mukrabe E.\} and Postema, \{Merel C.\} and \{Van De Giessen\}, Elsmarieke and Charlotte Teunissen and \{van Harten\}, Argonde and \{van der Flier\}, Wiesje and SAM Sikkes",

year = "2026",

month = jan,

day = "4",

doi = "10.1002/dad2.70233",

language = "English",

volume = "18",

pages = "1--11",

journal = "Alzheimer's \& Dementia: Diagnosis, Assessment \& Disease Monitoring",

issn = "2352-8729",

publisher = "Wiley",

number = "1",

}

van der Putten-Toorenburg, A , Butterbrod, E, Schalet, BD, van der Veere, PJ, Tewolde, ME, Postema, MC, Van De Giessen, E, Teunissen, C, van Harten , A, van der Flier, W & Sikkes, SAM 2026, 'The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 18, no. 1, e70233, pp. 1-11. https://doi.org/10.1002/dad2.70233

The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort. / van der Putten-Toorenburg, Angela ; Butterbrod, Elke; Schalet, Benjamin D. et al.
In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 18, No. 1, e70233, 03.2026, p. 1-11.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort

AU - van der Putten-Toorenburg, Angela

AU - Butterbrod, Elke

AU - Schalet, Benjamin D.

AU - van der Veere, Pieter J.

AU - Tewolde, Mukrabe E.

AU - Postema, Merel C.

AU - Van De Giessen, Elsmarieke

AU - Teunissen, Charlotte

AU - van Harten , Argonde

AU - van der Flier, Wiesje

AU - Sikkes, SAM

PY - 2026/1/4

Y1 - 2026/1/4

N2 - INTRODUCTION We explored the relationship between cognitive screening outcomes and everyday functioning in Alzheimer's disease (AD). METHODS A total of 1228 amyloid-positive participants were included from the Amsterdam Dementia Cohort. Multiple linear regression analyses assessed the relationship between Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and everyday functioning (Amsterdam Instrumental Activities of Daily Living Questionnaire [A-IADL-Q-30]). To link cognitive screeners to functional impairment, we described difficulties across A-IADL-Q-30 items by MMSE and MoCA quartiles. RESULTS Both MMSE (B = 0.96, 95% confidence interval [CI]0.87–1.04) and MoCA (B = 0.79, 95% CI 0.68–0.89) were associated with A-IADL-Q-30. In the lowest MMSE (0–20) and MoCA (0–16) quartiles, filling in forms (both 96%) and managing the household budget (95%–93%) were mostly affected, whereas working (74%) and using a computer (52%–50%) were primarily affected in the highest quartiles (MMSE 28–30/MoCA 25–30). DISCUSSION In amyloid-positive participants, the association between cognition and daily functioning was moderate, reinforcing the importance of assessing both constructs in disease monitoring.

AB - INTRODUCTION We explored the relationship between cognitive screening outcomes and everyday functioning in Alzheimer's disease (AD). METHODS A total of 1228 amyloid-positive participants were included from the Amsterdam Dementia Cohort. Multiple linear regression analyses assessed the relationship between Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and everyday functioning (Amsterdam Instrumental Activities of Daily Living Questionnaire [A-IADL-Q-30]). To link cognitive screeners to functional impairment, we described difficulties across A-IADL-Q-30 items by MMSE and MoCA quartiles. RESULTS Both MMSE (B = 0.96, 95% confidence interval [CI]0.87–1.04) and MoCA (B = 0.79, 95% CI 0.68–0.89) were associated with A-IADL-Q-30. In the lowest MMSE (0–20) and MoCA (0–16) quartiles, filling in forms (both 96%) and managing the household budget (95%–93%) were mostly affected, whereas working (74%) and using a computer (52%–50%) were primarily affected in the highest quartiles (MMSE 28–30/MoCA 25–30). DISCUSSION In amyloid-positive participants, the association between cognition and daily functioning was moderate, reinforcing the importance of assessing both constructs in disease monitoring.

U2 - 10.1002/dad2.70233

DO - 10.1002/dad2.70233

M3 - Article

SN - 2352-8729

VL - 18

SP - 1

EP - 11

JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

IS - 1

M1 - e70233

ER -

van der Putten-Toorenburg A , Butterbrod E, Schalet BD, van der Veere PJ, Tewolde ME, Postema MC et al. The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2026 Mar;18(1):1-11. e70233. Epub 2026 Jan 4. doi: 10.1002/dad2.70233

The relationship between cognitive screeners and everyday functioning in amyloid‐positive participants from the Amsterdam Dementia Cohort

Abstract

Funding

Access to Document

Persistent URL (handle)

Fingerprint

Cite this