The ribosome and YidC: new insights into the biogenesis of Escherichia coli inner membrane proteins.

J.-W. de Gier, S. Luirink

Research output: Contribution to JournalArticleAcademic

Abstract

In the bacterium Escherichia coli, inner membrane proteins (IMPs) are generally targeted through the signal recognition particle pathway to the Sec translocon, which is capable of both linear transport into the periplasm and lateral transport into the lipid bilayer. Lateral transport seems to be assisted by the IMP YidC. in this article, we discuss recent observations that point to a key role for the ribosome in IMP targeting and to the diverse roles of YidC in IMP assembly.
Original languageEnglish
Pages (from-to)939-943
Number of pages5
JournalEMBO Reports
Volume4
DOIs
Publication statusPublished - 2003

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