The role of lifestyle factors in cognitive health and dementia in oldest-old: A systematic review

Kaisy Xinhong Ye; Lina Sun; Lingyan Wang; Anderson Li Yang Khoo; Kai Xuan Lim; Guohua Lu; Lirong Yu; Changjiang Li; Andrea Britta Maier; Lei Feng

doi:10.1016/j.neubiorev.2023.105286

The role of lifestyle factors in cognitive health and dementia in oldest-old: A systematic review

Kaisy Xinhong Ye, Lina Sun^*, Lingyan Wang, Anderson Li Yang Khoo, Kai Xuan Lim, Guohua Lu, Lirong Yu, Changjiang Li, Andrea Britta Maier, Lei Feng^*

^*Corresponding author for this work

Research output: Contribution to Journal › Review article › Academic › peer-review

Abstract

Oldest-old is the fastest growing segment of society. A substantial number of these individuals are cognitively impaired or demented. Given the lack of a cure, attention is directed to lifestyle interventions that could help alleviate the stress in patients, their families, and society. The aim of this review was to identify lifestyle factors with important roles in dementia prevention in oldest-old. Searches were conducted in PubMed, EMBASE, Scopus and Web of Science. We identified 27 observational cohort studies that met the inclusion criteria. Results showed that eating a healthy diet with plenty of fruits and vegetables, and participation in leisure and physical activities may protect against cognitive decline and cognitive impairment among oldest-old regardless of the APOE genotype. Combined lifestyles may generate multiplicative effects than individual factors. This is the first review known to systematically examine the association between lifestyle and cognitive health in oldest-old. Lifestyle interventions for diet, leisure, or a combination of lifestyles could be beneficial for cognitive function in oldest-old. Interventional studies are warranted to strengthen the evidence.

Original language	English
Article number	105286
Pages (from-to)	1-14
Number of pages	14
Journal	Neuroscience and Biobehavioral Reviews
Volume	152
Early online date	13 Jun 2023
DOIs	https://doi.org/10.1016/j.neubiorev.2023.105286
Publication status	Published - Sept 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Keywords

Cognitive function
Diet
Leisure activity
Lifestyle
Oldest-old
Physical exercise

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10.1016/j.neubiorev.2023.105286

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title = "The role of lifestyle factors in cognitive health and dementia in oldest-old: A systematic review",

abstract = "Oldest-old is the fastest growing segment of society. A substantial number of these individuals are cognitively impaired or demented. Given the lack of a cure, attention is directed to lifestyle interventions that could help alleviate the stress in patients, their families, and society. The aim of this review was to identify lifestyle factors with important roles in dementia prevention in oldest-old. Searches were conducted in PubMed, EMBASE, Scopus and Web of Science. We identified 27 observational cohort studies that met the inclusion criteria. Results showed that eating a healthy diet with plenty of fruits and vegetables, and participation in leisure and physical activities may protect against cognitive decline and cognitive impairment among oldest-old regardless of the APOE genotype. Combined lifestyles may generate multiplicative effects than individual factors. This is the first review known to systematically examine the association between lifestyle and cognitive health in oldest-old. Lifestyle interventions for diet, leisure, or a combination of lifestyles could be beneficial for cognitive function in oldest-old. Interventional studies are warranted to strengthen the evidence.",

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author = "Ye, {Kaisy Xinhong} and Lina Sun and Lingyan Wang and Khoo, {Anderson Li Yang} and Lim, {Kai Xuan} and Guohua Lu and Lirong Yu and Changjiang Li and Maier, {Andrea Britta} and Lei Feng",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

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doi = "10.1016/j.neubiorev.2023.105286",

language = "English",

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AU - Sun, Lina

AU - Wang, Lingyan

AU - Khoo, Anderson Li Yang

AU - Lim, Kai Xuan

AU - Lu, Guohua

AU - Yu, Lirong

AU - Li, Changjiang

AU - Maier, Andrea Britta

AU - Feng, Lei

PY - 2023/9

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N2 - Oldest-old is the fastest growing segment of society. A substantial number of these individuals are cognitively impaired or demented. Given the lack of a cure, attention is directed to lifestyle interventions that could help alleviate the stress in patients, their families, and society. The aim of this review was to identify lifestyle factors with important roles in dementia prevention in oldest-old. Searches were conducted in PubMed, EMBASE, Scopus and Web of Science. We identified 27 observational cohort studies that met the inclusion criteria. Results showed that eating a healthy diet with plenty of fruits and vegetables, and participation in leisure and physical activities may protect against cognitive decline and cognitive impairment among oldest-old regardless of the APOE genotype. Combined lifestyles may generate multiplicative effects than individual factors. This is the first review known to systematically examine the association between lifestyle and cognitive health in oldest-old. Lifestyle interventions for diet, leisure, or a combination of lifestyles could be beneficial for cognitive function in oldest-old. Interventional studies are warranted to strengthen the evidence.

AB - Oldest-old is the fastest growing segment of society. A substantial number of these individuals are cognitively impaired or demented. Given the lack of a cure, attention is directed to lifestyle interventions that could help alleviate the stress in patients, their families, and society. The aim of this review was to identify lifestyle factors with important roles in dementia prevention in oldest-old. Searches were conducted in PubMed, EMBASE, Scopus and Web of Science. We identified 27 observational cohort studies that met the inclusion criteria. Results showed that eating a healthy diet with plenty of fruits and vegetables, and participation in leisure and physical activities may protect against cognitive decline and cognitive impairment among oldest-old regardless of the APOE genotype. Combined lifestyles may generate multiplicative effects than individual factors. This is the first review known to systematically examine the association between lifestyle and cognitive health in oldest-old. Lifestyle interventions for diet, leisure, or a combination of lifestyles could be beneficial for cognitive function in oldest-old. Interventional studies are warranted to strengthen the evidence.

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The role of lifestyle factors in cognitive health and dementia in oldest-old: A systematic review

Abstract

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Keywords

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