The role of systemic inflammation linking maternal BMI to neurodevelopment in children

Jelske W van der Burg; Sarbattama Sen; Virginia R Chomitz; Jaap C Seidell; Alan Leviton; Olaf Dammann

doi:10.1038/pr.2015.179

The role of systemic inflammation linking maternal BMI to neurodevelopment in children

Jelske W van der Burg, Sarbattama Sen, Virginia R Chomitz, Jaap C Seidell, Alan Leviton, Olaf Dammann

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Children of obese mothers are at increased risk of developmental adversities. Maternal obesity is linked to an inflammatory in utero environment, which, in turn, is associated with neurodevelopmental impairments in the offspring. This is an integrated mechanism review of animal and human literature related to the hypothesis that maternal obesity causes maternal and fetal inflammation, and that this inflammation adversely affects the neurodevelopment of children. We propose integrative models in which several aspects of inflammation are considered along the causative pathway linking maternal obesity with neurodevelopmental limitations.

Original language	English
Pages (from-to)	3-12
Number of pages	10
Journal	Pediatric Research
Volume	79
Issue number	1-1
Early online date	16 Sep 2015
DOIs	https://doi.org/10.1038/pr.2015.179
Publication status	Published - Jan 2016

Keywords

Animals
Attention Deficit Disorder with Hyperactivity
Autistic Disorder
Biomarkers
Body Mass Index
Brain
Causality
Child
Child, Preschool
Cognition Disorders
Confounding Factors (Epidemiology)
Disease Models, Animal
Female
Humans
Infant
Infant, Newborn
Inflammation
Male
Models, Biological
Neurodevelopmental Disorders
Obesity
Pregnancy
Pregnancy Complications
Prenatal Exposure Delayed Effects
Psychotic Disorders
Risk
Journal Article
Research Support, N.I.H., Extramural
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/pr.2015.179

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title = "The role of systemic inflammation linking maternal BMI to neurodevelopment in children",

abstract = "Children of obese mothers are at increased risk of developmental adversities. Maternal obesity is linked to an inflammatory in utero environment, which, in turn, is associated with neurodevelopmental impairments in the offspring. This is an integrated mechanism review of animal and human literature related to the hypothesis that maternal obesity causes maternal and fetal inflammation, and that this inflammation adversely affects the neurodevelopment of children. We propose integrative models in which several aspects of inflammation are considered along the causative pathway linking maternal obesity with neurodevelopmental limitations.",

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author = "{van der Burg}, {Jelske W} and Sarbattama Sen and Chomitz, {Virginia R} and Seidell, {Jaap C} and Alan Leviton and Olaf Dammann",

year = "2016",

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doi = "10.1038/pr.2015.179",

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AU - Sen, Sarbattama

AU - Chomitz, Virginia R

AU - Seidell, Jaap C

AU - Leviton, Alan

AU - Dammann, Olaf

PY - 2016/1

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KW - Autistic Disorder

KW - Biomarkers

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KW - Cognition Disorders

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KW - Male

KW - Models, Biological

KW - Neurodevelopmental Disorders

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JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 1-1

ER -

The role of systemic inflammation linking maternal BMI to neurodevelopment in children

Abstract

Keywords

UN SDGs

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