Abstract
The microbiome is extremely important for human health; more recently its role in the context of cancer became clear. Microbial effects range from enhancing cancer immunity and cancer therapy efficacy, to promoting cancer progression and inhibiting treatment efficacy. These broad implications led researchers to investigate these specific interactions, as well as how modification of the microbiome can improve cancer survival and treatment efficacy. While these interactions are better established for cancers such as gastric cancer, they are far less understood in others. As non-small cell lung cancer (NSCLC) makes up the majority of lung cancer cases, and is among the top causes of cancer deaths worldwide, understanding the mechanisms by which the microbiome may impact progression and treatment is crucial to improve patient survival and treatment response. A literature review was conducted to reveal the crosslink between human microbiome and lung cancer. This includes immune priming, induction of pro- or anti-tumor response,
| Original language | English |
|---|---|
| Pages (from-to) | 4807-4818 |
| Number of pages | 12 |
| Journal | Anticancer Research |
| Volume | 40 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sept 2020 |
Bibliographical note
Funding Information:This work was partially supported by grants from Cancer Center Amsterdam (CCA 2016) to E.G. and D.D, and AIRC Start-Up grant (E.G) and Polish National Science Center project 2018/31/B/NZ7/02909 (G.J.P, E.G).
Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
Funding
This work was partially supported by grants from Cancer Center Amsterdam (CCA 2016) to E.G. and D.D, and AIRC Start-Up grant (E.G) and Polish National Science Center project 2018/31/B/NZ7/02909 (G.J.P, E.G).
Keywords
- Cancer therapy
- Carcinogenesis
- Lung cancer
- Microbiome
- Review
