The search for stable prognostic models in multiple imputed data sets

D. Vergouw, M.W. Heijmans, G.M. Peat, T. Kuijpers, P.R. Croft, H.C.W. de Vet, H.E. van der Horst, D.A.W.M. van der Windt

Research output: Contribution to JournalArticleAcademicpeer-review

139 Downloads (Pure)


Background: In prognostic studies model instability and missing data can be troubling factors. Proposed methods for handling these situations are bootstrapping (B) and Multiple imputation (MI). The authors examined the influence of these methods on model composition. Methods: Models were constructed using a cohort of 587 patients consulting between January 2001 and January 2003 with a shoulder problem in general practice in the Netherlands (the Dutch Shoulder Study). Outcome measures were persistent shoulder disability and persistent shoulder pain. Potential predictors included socio-demographic variables, characteristics of the pain problem, physical activity and psychosocial factors. Model composition and performance (calibration and discrimination) were assessed for models using a complete case analysis, MI, bootstrapping or both MI and bootstrapping. Results: Results showed that model composition varied between models as a result of how missing data was handled and that bootstrapping provided additional information on the stability of the selected prognostic model. Conclusion: In prognostic modeling missing data needs to be handled by MI and bootstrap model selection is advised in order to provide information on model stability. © 2010 Vergouw et al; licensee BioMed Central Ltd.
Original languageEnglish
Pages (from-to)81
Number of pages9
JournalBMC Medical Research Methodology
Publication statusPublished - 2010


Dive into the research topics of 'The search for stable prognostic models in multiple imputed data sets'. Together they form a unique fingerprint.

Cite this